Zusammenfassung
Uterusmyome sind die häufigste benigne Raumforderung im weiblichen Genitaltrakt, 20% aller Frauen über 35 Jahren sind davon betroffen. Meist sind sie asymptomatisch, Myome können jedoch auch zu Meno-, Metrorrhagien, Hyper- und Dysmenorrhoe sowie Beschwerden bei Miktion und Defäkation führen. Während bei fehlender klinischer Symptomatik und insuspektem Befund kein therapeutischer Handlungsbedarf besteht, wird bei klinischer Symptomatik die Indikation zur therapeutischen Intervention gestellt. Neben der medikamentösen Therapie mit Gestagenen und GnRH-(Gonadotropine-releasing-hormone-)Analoga ist die Operation das Verfahren der Wahl. Während bei abgeschlossener Familienplanung eine Hysterektomie sinnvoll ist, wird bei Wunsch nach Organerhalt eine Myomenukleation durchgeführt, wobei endoskopische Verfahren und ein abdominaler Zugangsweg gewählt werden können. Die radiologisch interventionelle Myomembolisation stellt aufgrund ihrer geringeren Invasivität eine interessante Alternative dar.
Abstract
Uterine fibroids are the most common benign tumour affecting the female reproductive tract, 20% of all women older than 35 years are afflicted. Patients with fibroids tend to be asymptomatic, but fibroids may lead to meno-, metrorrhagia, hyper- and dysmenorrhoea and urination and defecation problems. If the fibroids do not cause any clinical symptoms and if there is no suspicion of a malignant tumor, there is no need for therapeutic intervention. Otherwise, besides the medical management with gestagenes and GnRH (gonadotropin-releasing hormone) analog, surgery represents the classical treatment. Hysterectomy is the common approach for women with completed family planning. For women who wish to conserve their fertility enucleation of the fibroids can be considered. These surgical procedures can be performed endoscopically or abdominally. Uterine artery embolisation, a radiological intervention, is less invasive and represents an interesting therapeutic alternative.
Literatur
Kaufmann M, Costa SD, Scharl A (2002) Die Gynäkologie, 1. Aufl. Springer, Berlin Heidelberg New York
Riede UN, Schaefer HE (1995) Allgemeine und spezielle Pathologie, 4. Aufl. Thieme, Stuttgart New York
Simsek T, Karakus C, Trak B (2002) Impact of different hormone replacement therapy regimens on the size of myoma uteri in postmenopausal period: tibolone versus transdermal hormonal replacement system. Maturitas 42(3):243–246
Schmidt-Matthiesen H, Hepp H (1998) Gynäkologie und Geburtshilfe—Lehrbuch für Studium und Praxis, 9. Aufl. Schattauer, Stuttgart New York
Strauss A (2003) Ultraschallpraxis—Geburtshilfe und Gynäkologie, 1. Aufl. Springer, Berlin Heidelberg New York
Lefebvre G, Vilos G, Allaire C et al. (2003)The management of uterine leiomyomas. J Obstet Gynaecol Can 25(5):396–418
Palomba S, Morelli M, Noia R et al. (2002) Short-term administration of tibolone plus GnRH analog before laparoscopic myomectomy. J Am Assoc Gynecol Laparosc 9(2):170–174
Ang WC, Farrell E, Vollenhoven B (2001) Effect of hormone replacement therapies and selective estrogen receptor modulators in postmenopausal women with uterine leiomyomas: a literature review. Climacteric 4(4):284–292
Hirsch HA, Käser O, Iklé FA (1999) Atlas der gynäkologischen Operationen, 6. Aufl. Thieme, Stuttgart New York
Hwang JL, Seow KM, Tsai YL, Huang LW, Hsieh BC, Lee C (2002) Comparative study of vaginal, laparoscopically assisted vaginal and abdominal hysterectomies for uterine myoma larger than 6 cm in diameter or uterus weighing at least 450 g: a prospective randomized study. Acta Obstet Gynecol Scand 81(12):1132–1138
Lumsden MA (2002) Embolization versus myomectomy versus hysterectomy: which is best, when? Hum Reprod 17(2):253–259
Rossetti A, Sizzi O, Soranna L, Cucinelli F, Mancuso S, Lanzone A (2001) Long-term results of laparoscopic myomectomy: recurrence rate in comparison with abdominal myomectomy. Hum Reprod 16(4):770–774
Hasbargen U, Summerer-Moustaki M, Hillemanns P, Scheidler J, Kimmig R, Hepp H (2002) Uterine dehiscence in a nullipara, diagnosed by MRI, following use of unipolar electrocautery during laparoscopic myomectomy: case report. Hum Reprod 17(8):2180–2182
Vercellini P, Maddalena S, De Giorgi O, Pesole A, Ferrari L, Crosignani PG (1999) Determinants of reproductive outcome after abdominal myomectomy for infertility. Fertil Steril 72(1):109–114
Dubuisson JB, Fauconnier A, Chapron C, Kreiker G, Norgaard C (2000) Reproductive outcome after laparoscopic myomectomy in infertile women. J Reprod Med 45(1):23–30
Ribeiro SC, Reich H, Rosenberg J, Guglielminetti E, Vidali A (1999) Laparoscopic myomectomy and pregnancy outcome in infertile patients. Fertil Steril 71(3):571–574
Roemisch M, Nezhat FR, Netzhat A (1996) Pregnancy after laparoscopic myomectomy. J Am Assoc Gynecol Laparosc 3 [suppl 4]:S42
Birinyi L, Kalamasz NZ, Major T, Borsos A, Bacsko G (2002) Evaluation of results in transcervical hysteroscopic myoma resection. Orv Hetil 143(49):2735–2740
Hasbargen U, Strauss A, Summerer-Moustaki M et al. (2002) Myomectomy as a pregnancy-preserving option in the carefully selected patient. Fetal Diagn Ther 17:101–103
Donnez J, Pirard C, Smets M, Polet R, Feger C, Squifflet J (2002) Unusual growth of a myoma during pregnancy. Fertil Steril 78(3):632–633
Phelan JP (1995) Myomas and pregnancy. Obstet Gynecol Clin North Am 22:801–805
Mollica G, Pittini L, Minganti E, Perri G, Pansisi F (1996) Elective uterine myomectomy in pregnant women. Clin Exp Obstet Gynecol 23:168–172
Kommoss F, DeGregorio G, Strittmatter B et al. (1993) Obstetric complications, incidence and indications of cesarean section in uterus myomatosus. Geburtsh Frauenheilkd 53(8):564–567
Baloniak B, Jasinski P, Drews K, Slomko Z (2002) Morphologic pattern of uterine myomas enucleated at cesarean section. Ginekol Pol 73(4):255–2559
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Middendorf, K., Burges, A., Strauss, A. et al. Uterusmyome—Behandlungsoptionen aus der Sicht des Gynäkologen. Radiologe 43, 615–623 (2003). https://doi.org/10.1007/s00117-003-0936-1
Issue Date:
DOI: https://doi.org/10.1007/s00117-003-0936-1