Folsäure- und Vitamin-B12-Bestimmung in der Diagnostik kognitiver Störungen

Übersicht und Datenanalyse einer universitären Gedächtnisambulanz

Folic acid and vitamin B12 determination in the assessment of cognitive disorders

Overview and data analysis from a university outpatient memory clinic


Vitamin-B12- und Folsäuremangelzustände sind insbesondere im höheren Lebensalter häufig. Da derartige Mangelzustände relevant dyskognitive Faktoren darstellen, ist ihre Bestimmung in der diagnostischen Abklärung kognitiver Störung bedeutsam und unverzichtbarer Bestandteil der Routinediagnostik in einer Gedächtnisambulanz. Wir geben einen Überblick über den klinischen Stellenwert von Vitamin-B12- und Folsäuremangelzuständen im Kontext kognitiver Störungen und über diesbezüglich relevante diagnostische und therapeutische Aspekte. Die Literaturübersicht wird durch eine Datenanalyse einer Kohorte von 250 Patienten aus unserer Gedächtnisambulanz ergänzt.


Vitamin B12 and folic acid deficiencies are particularly frequent conditions in older people. Since these metabolic disorders represent relevant dyscognitive factors, the assessment of vitamin B12 and folic acid levels is essential in the diagnostic approach of cognitive disorders, such as mild cognitive impairment and dementia in an outpatient memory clinic. This article summarizes the relevant diagnostic and therapeutic aspects of vitamin B12 and folic acid deficiencies and their effects on cognition. The literature review is supplemented by a data analysis of a naturalistic cohort of 250 patients from this outpatient memory clinic.

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Correspondence to Dr. Robert Haußmann.

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R. Haussmann, C. Sauer, S. Neumann, A. Zweiniger, J. Lange und M. Donix geben an, dass kein Interessenkonflikt besteht.

Alle beschriebenen Untersuchungen am Menschen oder an menschlichem Gewebe wurden mit Zustimmung der zuständigen Ethikkommission, im Einklang mit nationalem Recht sowie gemäß der Deklaration von Helsinki von 1975 (in der aktuellen, überarbeiteten Fassung) durchgeführt. Von allen beteiligten Patienten liegt eine Einverständniserklärung vor.

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Haußmann, R., Sauer, C., Neumann, S. et al. Folsäure- und Vitamin-B12-Bestimmung in der Diagnostik kognitiver Störungen. Nervenarzt 90, 1162–1169 (2019).

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  • Vitamin-B12-Mangel
  • Folsäuremangel
  • Kognitive Störungen
  • Leichte kognitive Störung
  • Demenz


  • Vitamin B12 deficiency
  • Folic acid deficiency
  • Cognitive impairments
  • Mild cognitive impairment
  • Dementia