Skip to main content
SpringerLink
Log in

Posteriore kortikale Atrophie – ein heterogenes Syndrom

Eine Fallserie

Posterior cortical atrophy—a heterogeneous syndrome

A case series

  • Kurzbeiträge
  • Published:
Der Nervenarzt Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3

Literatur

  1. Benson D, Davis R, Snyder B (1988) Posterior cortical atrophy. Arch Neurol 45:789–793

    Article  CAS  Google Scholar 

  2. Caroppo P, Belin C, Grabli D et al (2015) Posterior cortical atrophy as an extreme phenotype of GRN mutations. JAMA Neurol 72(2):224–228

    Article  Google Scholar 

  3. Crutch SJ, Lehmann M, Schott J et al (2012) Posterior cortical atrophy. Lancet Neurol 11:170–178

    Article  Google Scholar 

  4. Crutch SJ, Schott JM, Rabinovici GD et al (2017) Consensus classification of posterior cortical atrophy. Alzheimers Dement 13:870–884

    Article  Google Scholar 

  5. Ikonomovic M, Klunk W, Abrahamson E et al (2008) Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of AD. Brain 131:1630–1645

    Article  Google Scholar 

  6. Jack CR, Bennett DA, Blennow K, Carrillo MC, Dunne B, Haeberlein SB et al (2018) NIA-AA research framework: toward a biological definition of alzheimer’s disease. Alzheimers Dement 14(4):535–562

    Article  Google Scholar 

  7. Lehmann M, Crutch S, Ridgway G et al (2011) Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer’s disease. Neurobiol Aging 32:1466–1476

    Article  Google Scholar 

  8. Lehmann M, Ghosh P, Madison C et al (2013) Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease. Brain 136:844–858

    Article  Google Scholar 

  9. Nestor PJ, Caine D, Fryer TD et al (2003) The topography of metabolic deficits in posterior cortical atrophy (the visual variant of Alzheimer’s disease) with FDG-PET. J Neurol Neurosurg Psychiatr 74:1521–1529

    Article  CAS  Google Scholar 

  10. Niethammer M, Tang CC, Feigin A, Allen PJ, Heinen L, Hellwig S et al (2014) A disease-specific metabolic brain network associated with corticobasal degeneration. Brain 137:3036–3046

    Article  Google Scholar 

  11. Ortner M, Kurz A (2015) Posteriore kortikale Atrophie – Pathologie, Diagnostik und Behandlung einer seltenen Form der Demenz. Nervenarzt 86:833–839

    Article  CAS  Google Scholar 

  12. Ossenkoppele R, Schonhaut DR, Scholl M et al (2016) Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease. Brain 139(5):1551–1567

    Article  Google Scholar 

  13. Peng G, Liu P, He F, Luo B (2016) Posterior cortical atrophy as a primary clinical phenotype of corticobasal syndrome with a progranulin gene rs5848 TT genotype. Orphanet J Rare Dis 11:13

    Article  Google Scholar 

  14. Ridha B, Crutch S, Cutler D, Frost C, Knight W, Barker S et al (2018) A double-blind placebo-controlled cross-over clinical trial of DONepezil In Posterior cortical atrophy due to underlying Alzheimer’s Disease: DONIPAD study. Alzheimers Res Ther 10(1):44

    Article  Google Scholar 

  15. Rossi G, Bastone A, Piccoli E et al (2014) Different mutations at V363 MAPT codon are associated with atypical clinical phenotypes and show unusual structural and functional features. Neurobiol Aging 35(2):408–417

    Article  CAS  Google Scholar 

  16. Schott JM, Crutch SJ, Carrasquillo MM et al (2016) Genetic risk factors for the posterior cortical atrophy variant of Alzheimer’s disease. Alzheimers Dement 12:862–871

    Article  Google Scholar 

  17. Seguin J, Formaglio M, Perret-Liaudet A et al (2011) CSF biomarkers in posterior cortical atrophy. Baillieres Clin Neurol 76:1782–1788

    CAS  Google Scholar 

  18. Sitek E, Narożańska E, Pepłońska B et al (2013) A patient with PCA posesses a novel mutation in the Presenilin 1 gene. PLoS ONE 8(4):e61074

    Article  CAS  Google Scholar 

  19. Spehl TS, Hellwig S, Amtage F, Weiller C, Bormann T, Weber WA et al (2015) Syndrome-specific patterns of regional cerebral glucose metabolism in posterior cortical atrophy in comparison to dementia with Lewy bodies and Alzheimer’s disease—a [F-18]-FDG pet study. J Neuroimaging 25(2):281–288

    Article  Google Scholar 

  20. Tremolizzo L, Susani E, Mapelli C et al (2015) First report of PSEN2 mutation presenting as posterior cortical atrophy. Azheimer Dis Assoc Disord 29:249–251

    Article  Google Scholar 

  21. Villemagne V, Ong K, Mulligan R et al (2011) Amyloid imaging with 18-F-Florbetaben in Alzheimer disease and other dementias. J Nucl Med 52:1210–1217

    Article  Google Scholar 

  22. Weill-Chounlamountry A, Alves J, Pradat-Diehl P (2016) Non-pharmacological intervention for posterior cortical atrophy. World J Clin Cases 4(8):195–201

    Article  Google Scholar 

  23. Yong KX, Rajdev K, Shakespeare TJ, Leff AP, Crutch SJ (2015) Facilitating text reading in posterior cortical atrophy. Baillieres Clin Neurol 85(4):339–348

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Neurologie, Ludwig-Maximilians-Universität München, Marchioninistraße 15, 81377, München, Deutschland

    Julian Conrad, Olympia Kremmyda, Tobias Högen, Johannes Levin & Adrian Danek

  2. Deutsches Schwindel- und Gleichgewichtszentrum (DSGZ), Ludwig-Maximilians-Universität München, München, Deutschland

    Julian Conrad & Olympia Kremmyda

  3. Klinik und Poliklinik für Nuklearmedizin, Ludwig-Maximilians-Universität München, München, Deutschland

    Matthias Brendel

  4. Universitätsklinik für Nuklearmedizin, Inselspital, Universitätsspital Bern, Bern, Schweiz

    Axel Rominger

  5. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Feodor-Lynen-Straße 17, 81377, München, Deutschland

    Johannes Levin

  6. Munich Cluster for Systems Neurology (SyNergy), München, Deutschland

    Johannes Levin

Authors
  1. Julian Conrad
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Olympia Kremmyda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tobias Högen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Matthias Brendel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Axel Rominger
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Johannes Levin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Adrian Danek
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Julian Conrad.

Ethics declarations

Interessenkonflikt

J. Conrad, O. Kremmyda, T. Högen, M. Brendel, A. Rominger, J. Levin und A. Danek geben an, dass kein Interessenkonflikt besteht.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Conrad, J., Kremmyda, O., Högen, T. et al. Posteriore kortikale Atrophie – ein heterogenes Syndrom. Nervenarzt 90, 1045–1050 (2019). https://doi.org/10.1007/s00115-019-0697-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00115-019-0697-3

Search

Navigation