Skip to main content
Log in

Fulminante EBV-Meningoenzephalitis

Gutes klinisches Outcome bei einer jungen, immunkompetenten Frau

Fulminant EBV meningoencephalitis

Good clinical outcome in a young, immunocompetent female

  • Kurzbeiträge
  • Published:
Der Nervenarzt Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2

Literatur

  1. Abul-Kasim K, Palm L, Maly P et al (2009) The neuroanatomic localization of Epstein-Barr virus encephalitis may be a predictive factor for its clinical outcome: a case report and review of 100 cases in 28 reports. J Child Neurol 24:720–726

    Article  PubMed  Google Scholar 

  2. Aronson MD, Auwaerter PG (2016) Infectious mononucleosis in adults and adolescents. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. http://www.uptodate.com/contents/infectious-mononucleosis-in-adults-andadolescents?source=search_result&search=infectious+mononucleosis&selectedTitle=1~150. Zugegriffen: 9. Nov. 2016

    Google Scholar 

  3. Ascenção BB, Gonçalves AC, Luís N et al (2016) Epstein-Barr virus hemorrhagic meningoencephalitis: case report and review of the literature. J Neurovirol 22:695–698

    Article  PubMed  Google Scholar 

  4. Bottcher J, Kunze A, Kurrat C et al (2005) Localized reversible reduction of apparent diffusion coefficient in transient hypoglycemia-induced hemiparesis. Stroke 36:e20–e22

    Article  CAS  PubMed  Google Scholar 

  5. Chen YJ, Fang PC, Chow JC (2006) Clinical characteristics and prognostic factors of postencephalitic epilepsy in children. J Child Neurol 21:1047–1051

    Article  PubMed  Google Scholar 

  6. Cinque P, Vago L, Dahl H et al (1996) Polymerase chain reaction on cerebrospinal fluid for diagnosis of virus-associated opportunistic diseases of the central nervous system in HIV-infected patients. AIDS 10:951–958

    Article  CAS  PubMed  Google Scholar 

  7. Corssmit EP, Leverstein-van Hall MA, Portegies P et al (1997) Severe neurological complications in association with Epstein-Barr virus infection. J Neurovirol 3:460–464

    Article  CAS  PubMed  Google Scholar 

  8. De Paor M, O’Brien K, Fahey T (2016) Antiviral agents for infectious mononucleosis (glandular fever). Cochrane Database Syst Rev:. doi:10.1002/14651858.CD011487.pub2

  9. Doja A, Bitnun A, Jones EL (2006) Pediatric Epstein-Barr virus-associated encephalitis: 10-year review. J Child Neurol 21:385–391

    Article  PubMed  Google Scholar 

  10. Domachowske JB, Cunningham CK, Cummings DL et al (1996) Acute manifestations and neurologic sequelae of Epstein-Barr virus encephalitis in children. Pediatr Infect Dis J 15:871–875

    Article  CAS  PubMed  Google Scholar 

  11. Ebell MH, Call M, Shinholser J et al (2016) Does This Patient Have Infectious Mononucleosis?: The Rational Clinical Examination Systematic Review. JAMA 315:1502–1509

    Article  CAS  PubMed  Google Scholar 

  12. Elbers JM, Bitnun A, Richardson SE et al (2007) A 12-year prospective study of childhood herpes simplex encephalitis: is there a broader spectrum of disease? Pediatrics 119:e399–407

    Article  PubMed  Google Scholar 

  13. Fujimoto H, Asaoka K, Imaizumi T et al (2003) Epstein-Barr virus infections of the central nervous system. Intern Med 42:33–40

    Article  PubMed  Google Scholar 

  14. Gautier-Smith PC (1965) Neurological complications of glandular fever (infectious mononucleosis). Brain 88:323–334

    Article  CAS  PubMed  Google Scholar 

  15. Hagemann G, Mentzel HJ, Weisser H et al (2006) Multiple reversible MR signal changes caused by Epstein-Barr virus encephalitis. AJNR Am J Neuroradiol 27:1447–1449

    CAS  PubMed  Google Scholar 

  16. Häusler M, Ramaekers VT, Doenges M et al (2002) Neurological complications of acute and persistent Epstein-Barr virus infection in paediatric patients. J Med Virol 68:253–263

    Article  PubMed  Google Scholar 

  17. Hufnagel A, Weber J, Marks S et al (2003) Brain diffusion after single seizures. Epilepsia 44:54–63

    Article  PubMed  Google Scholar 

  18. Jenson HB (2000) Acute complications of Epstein-Barr virus infectious mononucleosis. Curr Opin Pediatr 12:263–268

    Article  CAS  PubMed  Google Scholar 

  19. Lennon P, Crotty M, Fenton JE (2015) Infectious mononucleosis. BMJ 350:h1825

    Article  PubMed  Google Scholar 

  20. Meyding-Lamadé U, Strank C (2012) Herpesvirus infections of the central nervous system in immunocompromised patients. Ther Adv Neurol Disord 5:279–296

    Article  PubMed  PubMed Central  Google Scholar 

  21. Misra UK, Tan CT, Kalita J (2008) Viral encephalitis and epilepsy. Epilepsia 49 Suppl 6. DOI:13–18. doi:10.1111/j.1528-1167.2008.01751.x

  22. Okano M, Kawa K, Kimura H et al (2005) Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection. Am J Hematol 80:64–69

    Article  PubMed  Google Scholar 

  23. Rafailidis PI, Mavros MN, Kapaskelis A et al (2010) Antiviral treatment for severe EBV infections in apparently immunocompetent patients. J Clin Virol 49:151–157

    Article  CAS  PubMed  Google Scholar 

  24. Rezk E, Nofal YH, Hamzeh A et al (2015) Steroids for symptom control in infectious mononucleosis. Cochrane Database Syst Rev 11:CD004402. DOI doi:10.1002/14651858.CD004402.pub3

    Google Scholar 

  25. Schellinger PD, Sommer C, Leithäuser F et al (1999) Epstein-Barr virus meningoencephalitis with a lymphoma-like response in an immunocompetent host. Ann Neurol 45:659–662

    Article  CAS  PubMed  Google Scholar 

  26. Shian WJ, Chi CS (1996) Epstein-Barr virus encephalitis and encephalomyelitis: MR findings. Pediatr Radiol 26:690–693

    Article  CAS  PubMed  Google Scholar 

  27. Silverstein A, Steinberg G, Nathanson M (1972) Nervous system involvement in infectious mononucleosis. The heralding and-or major manifestation. Arch Neurol 26:353–358

    Article  CAS  PubMed  Google Scholar 

  28. Steiner I, Budka H, Chaudhuri A et al (2010) Viral meningoencephalitis: a review of diagnostic methods and guidelines for management. Eur J Neurol 17:999–e57

    Article  CAS  PubMed  Google Scholar 

  29. Torre D, Tambini R (1999) Acyclovir for treatment of infectious mononucleosis: a meta-analysis. Scand J Infect Dis 31:543–547

    Article  CAS  PubMed  Google Scholar 

  30. Tselis A (2014) Epstein-Barr virus infections of the nervous system. In: Tselis A, Booss J (Hrsg) Neurovirology (Handbook of Clinical Neurology), Elsevier B.V.

  31. Vince A, Lepej SZ, Kurelac I et al (2007) Virological and immunological characteristics of fatal Epstein-Barr virus mononucleosis in a 17-year-old Caucasian male presenting with meningoencephalitis and hemophagocytic syndrome. J Neurovirol 13:389–396

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to F. Derler.

Ethics declarations

Interessenkonflikt

F. Derler, S. Seidel und D. Bengel geben an, dass kein Interessenkonflikt besteht.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Derler, F., Seidel, S. & Bengel, D. Fulminante EBV-Meningoenzephalitis. Nervenarzt 88, 1186–1191 (2017). https://doi.org/10.1007/s00115-017-0381-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00115-017-0381-4

Navigation