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Chancen und Kontroversen von Depotantipsychotika in der Behandlung von Patienten mit Schizophrenie

Advantages and controversies of depot antipsychotics in the treatment of patients with schizophrenia

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Zusammenfassung

Hintergrund

Dieses Review soll einen Überblick über Vor- und Nachteile der Anwendung von Depotantipsychotika in der Therapie der Schizophrenie geben. Es erfolgt ein Vergleich zur oralen Anwendungsform, wobei der Fokus auf Wirksamkeit, Verträglichkeit, Rückfallverhütung und Patientenzufriedenheit liegt.

Material und Methoden

Wir führten eine Literaturrecherche in medizinischen Datenbanken durch. Dabei wurden Ergebnisse von Metaanalysen, randomisierten kontrollierten Studien und systematischen Reviews aus den Jahren 1999 bis 2014 miteinbezogen.

Ergebnisse und Diskussion

Depotantipsychotika ermöglichen die Aufrechterhaltung eines stabilen Medikamentenplasmaspiegels und tragen zur Sicherung der therapeutischen Wirkung bei. Sie führen zu einer Verbesserung der Compliance und senken dadurch die Rückfall- und Hospitalisierungsrate. Auf diese Weise wirken sich Depotantipsychotika nicht nur positiv auf den persönlichen Verlauf aus, sondern tragen auch dazu bei, die Gesundheitskosten zu senken.

Abstract

Background

The objective of this article is to give an overview of the advantages and disadvantages of the use of depot antipsychotics in the treatment of schizophrenia. The focus is on efficacy, tolerability, relapse prevention, patient compliance and satisfaction compared to oral administration forms.

Material and methods

A literature search was conducted in medical databases. The results of meta-analyses, randomized controlled trials and systematic reviews from the years 1999–2014 were included.

Results and discussion

Depot antipsychotics ensure maintenance of constant blood levels and a continuous medication delivery. The efficacy and tolerability of depot antipsychotics are comparable to oral administration forms. Due to an improved medication compliance a reduction of relapse and hospitalization rates can be achieved. This is a key focus for improving outcomes and reducing costs in the treatment of schizophrenia.

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Authors and Affiliations

  1. Universitätsklinik für Psychiatrie und Psychotherapie Universität Bern, Bolligenstr. 111, 3000, Bern, Schweiz

    S. Breit &  G. Hasler

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  1. S. Breit
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  2. G. Hasler
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Correspondence to G. Hasler.

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S. Breit und G. Hasler geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Breit, S., Hasler, G. Chancen und Kontroversen von Depotantipsychotika in der Behandlung von Patienten mit Schizophrenie. Nervenarzt 87, 719–723 (2016). https://doi.org/10.1007/s00115-015-0021-9

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