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Schlaf, Lernen und Gedächtnis: Relevanz für Psychiatrie und Psychotherapie

Sleep, learning and memory: relevance for psychiatry and psychotherapy

Der Nervenarzt volume 85, pages 50–56 (2014)Cite this article

Zusammenfassung

Hintergrund

Schlaf ist ein Zustand, der die Konsolidierung kürzlich erworbener Gedächtnisinhalte optimiert. Daher könnten Schlafstörungen zu Gedächtnisverminderungen bei psychiatrischen Erkrankungen wie der Depression oder der Schizophrenie beitragen.

Methode

Dieser Beitrag gibt einen Überblick über die aktuelle Forschung zum Thema Schlaf und Gedächtnis mit dem Fokus auf psychiatrische Erkrankungen.

Ergebnisse und Schlussfolgerungen

Störungen in der Schlafstruktur sind assoziiert mit bestimmten Gedächtnisdefiziten bei Patienten mit unterschiedlichen psychischen Erkrankungen. Wirksame Behandlungen von Schlafverminderungen sollten nicht nur den Schlaf an sich, sondern auch die assoziierten Gedächtniseinschränkungen verbessern. Erste Beispiele dafür werden genannt.

Summary

Background

Sleep has been identified as a state that optimizes the consolidation of newly acquired information in the memory. Sleep disturbances might essentially contribute to memory impairment in relevant psychiatric disorders, such as major depression and schizophrenia.

Methods

This article provides a brief review of the latest research results on sleep and its association with memory consolidation.

Results and conclusion

Specific disturbances of sleep structure are associated with particular memory deficits in psychiatric patients. Effective treatment of sleep disorders should not only improve signs of sleep but should also heal associated memory impairments.

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Literatur

  1. Ackermann S, Rasch B (2013) Differential effects of NonREM and REM sleep on memory consolidation. Curr Neurol Neurosci Rep (in press)

  2. Antonenko D, Diekelmann S, Olsen C et al (2013) Napping to renew learning capacity: enhanced encoding after stimulation of sleep slow oscillations. Eur J Neurosci 37:1142–1151

    PubMed  Article  Google Scholar 

  3. Backhaus J, Junghanns K, Born J et al (2006) Impaired declarative memory consolidation during sleep in patients with primary insomnia: influence of sleep architecture and nocturnal cortisol release. Biol Psychiatry 60:1324–1330

    CAS  PubMed  Article  Google Scholar 

  4. Baglioni C, Battagliese G, Feige B et al (2011) Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord 135:10–19

    PubMed  Article  Google Scholar 

  5. Baran B, Pace-Schott EF, Ericson C, Spencer RMC (2012) Processing of emotional reactivity and emotional memory over sleep. J Neurosci 32:1035–1042

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  6. Born J, Wilhelm I (2012) System consolidation of memory during sleep. Psychol Res 76:192–203

    PubMed Central  PubMed  Article  Google Scholar 

  7. Cartwright R, Agargun MY, Kirkby J, Friedman JK (2006) Relation of dreams to waking concerns. Psychiatry Res 141:261–270

    PubMed  Article  Google Scholar 

  8. Diekelmann S, Büchel C, Born J, Rasch B (2011) Labile or stable: opposing consequences for memory when reactivated during waking and sleep. Nat Neurosci 14:381–386

    CAS  PubMed  Article  Google Scholar 

  9. Ferrarelli F, Peterson M, Sarasso S et al (2010) Thalamic dysfunction in schizophrenia suggested by whole-night deficits in slow and fast spindles. Am J Psychiatry 167:1339–1348

    PubMed Central  PubMed  Article  Google Scholar 

  10. Gais S, Albouy G, Boly M et al (2007) Sleep transforms the cerebral trace of declarative memories. Proc Natl Acad Sci U S A 104:18778–18783

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  11. Göder R, Fritzer G, Gottwald B et al (2008) Effects of olanzapine on slow wave sleep, sleep spindles and sleep related memory consolidation in schizophrenia. Pharmacopsychiatry 41:92–99

    PubMed  Article  Google Scholar 

  12. Göder R, Born J (2013) Can sleep heal memory? Sleep Med Rev 17:89–90

    PubMed  Article  Google Scholar 

  13. Göder R, Baier PC, Beith B et al (2013) Effects of transcranial direct current stimulation during sleep on memory performance in patients with schizophrenia. Schizophr Res 144:153–154

    PubMed  Article  Google Scholar 

  14. Green MF, Kern RS, Braff DL, Mintz J (2000) Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the „right stuff“? Schizophr Bull 26:119–136

    CAS  PubMed  Article  Google Scholar 

  15. Gujar N, Yoo S, Hu P, Walker MP (2011) Sleep deprivation amplifies reactivity of brain reward networks, biasing the appraisal of positive emotional experiences. J Neurosci 31:4466–4474

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  16. Hauner KK, Howard J, Zelano C, Gottfried JA (2013) Stimulus-specific enhancement of fear extinction during slow-wave sleep. Nat Neurosci (in press)

  17. Huber R, Ghilardi M, Massimini M, Tononi G (2004) Local sleep and learning. Nature 430:78–81

    CAS  PubMed  Article  Google Scholar 

  18. Keshavan M, Reynolds CF, Miewald J et al (1998) Delta sleep deficits in schizophrenia. Am J Psychiatry 55:443–448

    CAS  Google Scholar 

  19. Kleim B, Wilhelm FH, Temp L et al (2013) Sleep enhances exposure therapy. Psychol Med 10:1–9

    Article  Google Scholar 

  20. Marshall L, Helgadóttir H, Mölle M, Born J (2006) Boosting slow oscillations during sleep potentiates memory. Nature 444:610–613

    CAS  PubMed  Article  Google Scholar 

  21. Marshall L, Kirov R, Brade J et al (2011) Transcranial electrical currents to probe EEG brain rhythms and memory consolidation during sleep in humans. PLoS One 6:e16905

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  22. Ngo HVV, Martinetz T, Born J, Mölle M (2013) Auditory closed-loop stimulation of the sleep slow oscillation enhances memory. Neuron 78:545–553

    CAS  PubMed  Article  Google Scholar 

  23. Nissen C, Kloepfer C, Feige B et al (2011) Sleep-related memory consolidation in primary insomnia. J Sleep Res 20:129–136

    PubMed  Article  Google Scholar 

  24. Nissen C, Holz J, Blechert J et al (2010) Learning as a model for neural plasticity in major depression. Biol Psychiatry 68:544–552

    PubMed  Article  Google Scholar 

  25. Palagini L, Baglioni C, Ciapparelli A et al (2013) REM sleep dysregulation in depression: state of the art. Sleep Med Rev 17:377–390

    PubMed  Article  Google Scholar 

  26. Phillips KG, Bartsch U, McCarthy A et al (2012) Decoupling of sleep-dependent cortical and hippocampal interactions in a neurodevelopmental model of schizophrenia. Neuron 76:526–533

    CAS  PubMed  Article  Google Scholar 

  27. Rasch B, Born J (2013) About sleep’s role in memory. Physiol Rev 93:681–766

    CAS  PubMed  Article  Google Scholar 

  28. Rasch B, Büchel C, Gais S, Born J (2007) Odor cues during slow-wave sleep prompt declarative memory consolidation. Science 315:1426–1429

    CAS  PubMed  Article  Google Scholar 

  29. Riemann D (2010) Hyperarousal and insomnia: state of the science. Sleep Med Rev 14:17

    PubMed  Article  Google Scholar 

  30. Rudoy JD, Voss J, Westerberg C, Paller KA (2009) Strengthening individual memories by reactivating them during sleep. Science 326:1079

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  31. Tononi G, Cirelli C (2006) Sleep function and synaptic homeostasis. Sleep Med Rev 10:49–62

    PubMed  Article  Google Scholar 

  32. Van der Helm, Walker MP (2011) Sleep and emotional memory processing. Sleep Med Clin 6:31–43

    Article  Google Scholar 

  33. Van der Helm E, Yao J, Dutt S et al (2011) REM sleep depotentiates amygdala activity to previous emotional experiences. Curr Biol 21:2029–2032

    Article  Google Scholar 

  34. Van der Werf YD, Altena E, Schoonheim M et al (2009) Sleep benefits subsequent hippocampal functioning. Nat Neurosci 12:122–123

    Article  Google Scholar 

  35. Wagner U, Gais S, Born J (2001) Emotional memory formation is enhanced across sleep intervals with high amounts of rapid eye movement sleep. Learn Mem 8:112–119

    CAS  PubMed  Article  Google Scholar 

  36. Wagner U, Hallschmid M, Rasch B, Born J (2006) Brief sleep after learning keeps emotional memories alive for years. Biol Psychiatry 60:788–790

    PubMed  Article  Google Scholar 

  37. Wamsley EJ, Tucker MA, Shinn AK et al (2012) Reduced sleep spindles and spindle coherence in schizophrenia: mechanisms of impaired memory consolidation? Biol Psychiatry 71(2):154–161

    PubMed Central  PubMed  Article  Google Scholar 

  38. Wamsley EJ, Shinn A, Tucker M et al (2013) The effects of eszopiclone on sleep spindles and memory consolidation in schizophrenia: a randomized placebo-controlled trial. Sleep 36:1369–1376

    PubMed  Google Scholar 

  39. Born J, Rasch B, Gais S (2006) Sleep to remember. Neuroscientist 12(5):410–424

    PubMed  Article  Google Scholar 

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Danksagung

Wir danken der DFG für die Förderung wesentlicher Studien, insbesondere über den SFB 654 Plastizität und Schlaf TP A9 (R.G.) sowie VO 542/9-1 (C.N.) und SNF PP00P1_133685 (B.R.).

Einhaltung ethischer Richtlinien

Interessenkonflikt. R. Göder und B. Rasch geben an, dass kein Interessenkonflikt besteht. C. Nissen hat Vortragshonorare von den Firmen Servier und Novartis erhalten. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Author information

Authors and Affiliations

  1. Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Schleswig-Holstein, Niemannsweg 147, 24105, Kiel, Deutschland

    R. Göder

  2. Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Freiburg, Freiburg, Deutschland

    C. Nissen

  3. Institut für Kognitive Biopsychologie und Methoden, Department für Psychologie, Universität Freiburg, Freiburg, Schweiz

    B. Rasch

Authors
  1. R. Göder
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  2. C. Nissen
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  3. B. Rasch
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Corresponding author

Correspondence to R. Göder.

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Göder, R., Nissen, C. & Rasch, B. Schlaf, Lernen und Gedächtnis: Relevanz für Psychiatrie und Psychotherapie. Nervenarzt 85, 50–56 (2014). https://doi.org/10.1007/s00115-013-3894-5

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  • DOI: https://doi.org/10.1007/s00115-013-3894-5

Schlüsselwörter

  • Schlaf
  • Gedächtniskonsolidierung
  • Insomnie
  • Depressive Episode
  • Schizophrenie

Keywords

  • Sleep
  • Memory consolidation
  • Insomnia
  • Major depression
  • Schizophrenia