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Innovative MRT-Verfahren bei idiopathischem Parkinson-Syndrom

Innovative MRI techniques in Parkinson’s disease

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Zusammenfassung

Moderne bildgebende Verfahren ermöglichen die detaillierte Untersuchung von Struktur und Funktion des Gehirns bei Patienten mit idiopathischem Parkinson-Syndrom (IPS). Neben den etablierten Methoden wurden in den letzten Jahren neuartige MRT-Verfahren entwickelt und zur Bearbeitung wissenschaftlicher Fragestellungen eingesetzt. Dabei steht die Untersuchung verschiedener Aspekte von Hirngewebseigenschaften (MR-Relaxometrie, SWI, DWI, DTI, VBM) sowie der zerebralen Perfusion und Hirnaktivität (ASL, fcMRT) im Vordergrund des Interesses. Neben der Aufklärung der Pathophysiologie des IPS sind diese MRT-Methoden möglicherweise auch zur Untersuchung der Progressionsdynamik der Erkrankung sowie des Einflusses therapeutischer Interventionen geeignet. Daneben könnten sie möglicherweise zu einer valideren differenzialdiagnostischen Zuordnung der Parkinson-Syndrome beitragen.

Summary

Brain imaging enables the investigation of brain morphology and function in patients with Parkinson’s disease (PD). Innovative magnetic resonance imaging (MRI) techniques have recently been established as a new research tool in PD. They are based on the investigation of neuronal tissue properties (MR relaxometry, SWI, DWI, DTI, VBM) and of cerebral perfusion and neuronal activity (ASL, fcMRI). Besides a better understanding of the pathophysiology of PD, these innovative MR techniques might be suitable for measuring progression of PD and the effect of therapeutic interventions on brain functioning. In the clinical setting, they could help to advance the differential diagnosis of parkinsonian disorders.

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Authors and Affiliations

  1. Klinik für Neurologie, Zentrum der Neurologie und Neurochirurgie,Klinikum der Goethe-Universität Frankfurt am Main, Schleusenweg 2–16, 60528, Frankfurt am Main, Deutschland

    S. Baudrexel, J.C. Klein & R. Hilker

  2. Brain Imaging Center, Goethe-Universität Frankfurt am Main, Frankfurt am Main, Deutschland

    S. Baudrexel & R. Deichmann

Authors
  1. S. Baudrexel
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  2. J.C. Klein
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  3. R. Deichmann
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  4. R. Hilker
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Correspondence to S. Baudrexel.

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Baudrexel, S., Klein, J., Deichmann, R. et al. Innovative MRT-Verfahren bei idiopathischem Parkinson-Syndrom. Nervenarzt 81, 1180–1188 (2010). https://doi.org/10.1007/s00115-010-3023-7

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  • DOI: https://doi.org/10.1007/s00115-010-3023-7

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