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Bipolare Depression

Epidemiologie, Ätiopathogenese und Verlauf

Bipolar depression

Epidemiology, etiopathogenesis, and course

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Zusammenfassung

Bipolare Störungen gehören zu den häufigen und schwersten psychischen Erkrankungen. Der meist durch zahlreiche Erkrankungsepisoden gezeichnete Verlauf wird insbesondere durch die bipolaren Depressionen dominiert. In der multifaktoriellen Genese werden genetische, neurobiologische und psychosoziale Faktoren als pathogenetisch relevant angesehen. Es finden sich bei dieser Erkrankung vor allem Hinweise auf dysfunktionale Neurotransmittersysteme, Veränderungen von Neuroendokrinologie und intrazellulärer Signaltransduktion und auffällige neuroanatomische Befunde. Dieser Beitrag stellt die aktuellen Forschungsergebnisse zu Epidemiologie, Ätiopathogenese, und Verlauf der bipolaren Störung unter besonderer Berücksichtigung der Depression bei bipolaren Störungen dar.

Summary

Bipolar disorder is one of the most frequent and severe mental disorders. A generally recurrent or chronic course is often predominated by bipolar depression. Genetic, neurobiological, and psychosocial factors are supposed to be relevant in the pathophysiology of this disorder. Current data have implicated dysfunction of neurotransmitter, neuroendocrine, and intracellular signaling networks. Neuroanatomic changes in bipolar disorder have been reported, too. In this article, we describe current knowledge regarding epidemiology, etiopathogenesis, and course of bipolar disorder with a focus on depression of bipolar disorder.

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Interessenkonflikt

Der korrespondierende Autor Prof. Dr. Dr. Bauer weist auf folgende Beziehungen hin: Forschungszuwendungen durch Stanley Medical Research Institute, National Alliance for Research on Schizophrenia and Depression (NARSAD), Lilly; beratende Tätigkeit für AstraZeneca, GlaxoSmithKline, Lilly, Servier, Janssen-Cilag, Lundbeck, Essex Pharma, Bristol-Myers Squibb und Otsuka; Vortragshonorare von AstraZeneca, Lilly, Servier, GlaxoSmithKline, Lundbeck, Bristol-Myers Squibb, Otsuka und Pfizer.

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  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Fetscherstraße 74, 01307, Dresden, Deutschland

    S. Haack, A. Pfennig &  M. Bauer

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  1. S. Haack
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  2. A. Pfennig
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  3. M. Bauer
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Correspondence to M. Bauer.

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Haack, S., Pfennig, A. & Bauer, M. Bipolare Depression. Nervenarzt 81, 525–530 (2010). https://doi.org/10.1007/s00115-009-2849-3

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  • DOI: https://doi.org/10.1007/s00115-009-2849-3

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