Multiple Sklerose und Sport

Auswirkungen körperlicher Aktivität auf das Immunsystem

Multiple sclerosis and exercise

Effects of physical activity on the immune system


Die Multiple Sklerose ist eine chronisch entzündliche Erkrankung des Zentralnervensystems, die häufig bereits im jungen Erwachsenenalter zu funktionellen Einschränkungen und anhaltender Behinderung führt. Aktuelle Studien belegen, dass Sport bei Multipler Sklerose nicht nur Depression und Fatigue entgegenwirken, sondern auch die Lebensqualität der Patienten verbessern und funktionelle Einschränkungen reduzieren kann. Im vorliegenden Beitrag wird der Einfluss körperlicher Aktivität auf das Immunsystem und die Freisetzung neurotropher Faktoren erläutert und ein möglicher, immunmodulierender Effekt von Sport bei Multipler Sklerose diskutiert.


Multiple sclerosis is a chronic inflammatory CNS disease which accounts for functional impairment and lasting disability in young adults. Current studies demonstrate that physical activity in patients with MS counteracts depression and fatigue and may improve quality of life. Interventional studies have described a reduction of the functional impairment in MS patients. This report presents information on the effects of physical activity on the immune system and the release of neurotrophic factors, and highlights current data on a potential immunomodulatory effect of exercise in multiple sclerosis.

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Correspondence to PD Dr. M. Mäurer.

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Waschbisch, A., Tallner, A., Pfeifer, K. et al. Multiple Sklerose und Sport. Nervenarzt 80, 688–692 (2009).

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  • Multiple Sklerose
  • Sport
  • Körperliche Aktivität
  • Immunmodulation
  • Neurotrophe Faktoren


  • Multiple sclerosis
  • Exercise
  • Physical activity
  • Immunomodulation
  • Neurotrophic factors