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Neurolymphomatose

Subakute sensomotorische Polyneuropathie als Erstmanifestation eines Non-Hodgkin-B-Zell-Lymphoms

Neurolymphomatosis

Subacute sensorimotor polyneuropathy as a first sign of non-Hodgkin’s B cell lymphoma

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Zusammenfassung

Leitsymptom des bislang gesunden 65-jährigen Patienten war eine schmerzhafte, subakut aufgetretene, distal symmetrische, motorisch betonte Polyneuropathie mit Paraplegie der Fußheber und Fußsenker. Gleichzeitig bestand eine massive ödematöse Schwellung beider Beine. Elektrophysiologisch lag eine axonale Neuropathie mit akuter Denervation vor. Ursächlich war eine histologisch gesicherte Neurolymphomatose eines niedrigmalignen Non-Hodgkin-B-Zell-Lymphoms. Ungewöhnlich an diesem Fall ist die Erstmanifestation eines Non-Hodgkin-Lymphoms mit einer subakuten sensomotorischen Polyneuropathie.

Summary

We report on a 65-year-old patient with subacute painful sensorimotor polyneuropathy with distal leg muscle palsy and initially presenting with bilateral leg edema. Electrophysiologic testing showed an axonal lesion pattern with acute denervation. Nerve biopsy demonstrated neurolymphomatosis as an initial manifestation of a non-Hodgkin’s B cell lymphoma.

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Authors and Affiliations

  1. Abteilung für Neurologie, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg, Deutschland

    P.P. Urban, E. Kaczmarek & I. Wellach

  2. Röntgeninstitut, Asklepios Klinik Barmbek, Hamburg, Deutschland

    R. Brüning

  3. Abteilung für Onkologie, Asklepios Klinik Barmbek, Hamburg, Deutschland

    N. Brüllke

  4. Institut für Hämatopathologie, Hamburg, Deutschland

    C. Schulte

  5. Abteilung für Neurologie, Asklepios Klinik St. Georg, Hamburg, Deutschland

    K. Knop

  6. Institut für Neuropathologie, RWTH Aachen, Aachen, Deutschland

    J. Weis

Authors
  1. P.P. Urban
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  2. E. Kaczmarek
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  3. I. Wellach
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  4. R. Brüning
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  5. N. Brüllke
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  6. C. Schulte
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  7. K. Knop
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  8. J. Weis
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Corresponding author

Correspondence to P.P. Urban.

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Urban, P., Kaczmarek, E., Wellach, I. et al. Neurolymphomatose. Nervenarzt 79, 699–702 (2008). https://doi.org/10.1007/s00115-008-2456-8

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  • DOI: https://doi.org/10.1007/s00115-008-2456-8

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