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Migränerezidiv durch intrakranielle Metastasierung eines Schilddrüsenkarzinoms

Migraine recurrence due to intracranial metastasis of a thyroid carcinoma

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Zusammenfassung

Bei einer 57-jährigen Patientin mit einer Migräne ohne Aura im frühen Erwachsenenalter kam es unter einer intrakraniellen frontobasalen Metastase eines Schilddrüsenkarzinoms, welche auch zu erhöhten Prolaktinwerten führte, nach einem attackenfreien Intervall von 30 Jahren erneut zu wiederholt auftretenden typischen Migräneattacken. Der Mechanismus einer para- oder endokrinen Wirkung der Raumforderung und der damit verbundenen Triggerung von Migräneattacken wird diskutiert und zeigt die Bedeutung der intrakraniellen Tumoren als humanes Kopfschmerzmodell. Bei dem Wiederauftreten eines primären Kopfschmerzsyndroms nach langer Latenz sollte eine pathologische Ursache ausgeschlossen werden.

Summary

We report a 57-year-old female with a history of migraine without aura in her early adulthood who complained about new migraine attacks after being free of them for 30 years. As a possible trigger, an intracranial metastasis of a thyroid cancer was found which also caused elevated serum prolactin. The mechanism of a para- or endocrinal effect of the tumour is discussed, showing the relevance of intracranial tumours as a human headache model. The recurrence of a primary headache syndrome after long latency should result in the exclusion of a pathological cause.

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Danksagung

Unterstützt durch das BMBF (chronischer Kopfschmerz, Projekt D1) AZ: 01 EM 0513.

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Authors and Affiliations

  1. Neurologische Klinik und Poliklinik, Klinikum der Universität München-Großhadern, Marchioninistraße 15, 81377, München, Deutschland

    C.J. Schankin, J. Wagner, M. Elstner, V.M. Reinisch & A. Straube

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  1. C.J. Schankin
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  2. J. Wagner
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  3. M. Elstner
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  4. V.M. Reinisch
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  5. A. Straube
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Correspondence to C.J. Schankin.

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Schankin, C., Wagner, J., Elstner, M. et al. Migränerezidiv durch intrakranielle Metastasierung eines Schilddrüsenkarzinoms. Nervenarzt 79, 465–469 (2008). https://doi.org/10.1007/s00115-007-2396-8

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  • DOI: https://doi.org/10.1007/s00115-007-2396-8

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