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Atypische monoklonale Plasmazellhyperplasie

Infiltration des ZNS

Atypical monoclonal plasma cell hyperplasia

Infiltration of ZNS

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Zusammenfassung

Eine atypische monoklonale Plasmazellhyperplasie findet sich extrem selten im Zentralnervensystem (ZNS) ohne Knochen- oder Systemmanifestation. Diese neuropathologische Entiät wurde erstmals von Weidenheim et al. 1989 beschrieben. Sie wird als inflammatorischer Pseudotumor eingstuft, der sich in ein malignes Myelom entwickeln kann. Wir berichten über eine bilateral okzipital und zerebellär gelegene atypische monoklonale Plasmazellhyperplasie bei einer 38-jährigen Frau. Die Diagnose wurde immunhistochemisch und molekulargenetisch in einer Hirnbiopsie gesichert.

Summary

Atypical monoclonal plasma cell hyperplasia is extremely rare in the central nervous system without involvement of bone or other systemic disease. This neuropathological entity was first described by Weidenheim and colleagues in 1989. It is considered an inflammatory pseudotumor that can evolve into malignant myeloma. We report on an atypical monoclonal plasma cell hyperplasia with bilateral occipital and cerebellar involvement in a 38-year-old woman. The diagnosis was confirmed by brain biopsy immunohistochemical and molecular tests.

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Literatur

  1. Aozasa K, Iwangaga H, Kamata K (1987) Plasma cell granuloma of central nervous system. Histopathology 12: 98–100

    Google Scholar 

  2. Bahadori M, Liebow AA (1973) Plasma cell granulomas of the lung. Cancer 31: 191–208

    Article  PubMed  Google Scholar 

  3. Benli K, Inci S (1995) Solitary dural plasmacytoma: case report. Neurosurgery 36: 1206–1209

    PubMed  Google Scholar 

  4. Bindal AK, Bindal RK, Van Loveren H et al. (1995) Management of intracranial plasmacytoma. J Neurosurg 83: 218–221

    PubMed  Google Scholar 

  5. Brannan SO, Matthews BN, Savant V et al. (2003) Solitary intracranial extra-osseous plasmacytoma presenting with ophthalmic signs. J Neuroophthalmol 23: 268–271

    PubMed  Google Scholar 

  6. Cannella DM, Prezyna AP, Kapp JP (1988) Primary intracranial plasma-cell granuloma. Case report. J Neurosurg 69: 785–788

    PubMed  Google Scholar 

  7. Chen ZL (1986) Solitary intracranial plasmacytoma – a case report and review of the literature. Zhonghua Zhong Liu Za Zhi 8: 153–155

    PubMed  Google Scholar 

  8. Coppeta JR, Monteiro MLR, Collias J et al. (1983) Foster-Kennedy sydnrome caused by solitary intracranial plasmacytoma. Surg Neurol 19: 267–272

    Article  PubMed  Google Scholar 

  9. Figarelle-Branger D, Bambarelli D, Perez-Castillol M, et al. (1990) Primary intracerebral plasma cell granuloma: a light, immunocytochemical, and ultrastructural study of one case. Neurosurgery 27: 142–147

    Article  PubMed  Google Scholar 

  10. Harting I, Hartmann M, Sartor K (2004) Tumor-simulierende Läsionen in der kraniaen MRT. Fortschr Röntgenstr 176: 302–312

    Google Scholar 

  11. Hsiang JNK, Ho-Keung Ng, Poon WS (1996) Atypical monoclonal plasma cell hyperplasia: its identity and treatment. Case report. J Neurosurg 85: 697–700

    PubMed  Google Scholar 

  12. Inbasekaran V, Vijayarathinam P, Arumugam S (1991) Solitary intracerebral plasmacytoma. J Indian Med Assoc 89: 16–17

    Google Scholar 

  13. Kujat C, Reiche W, Koch B et al. (1996) Rare intracranial plasmacytoma manifestations. Case reports and review of the literature in diffuse plasmacytoma, in primary solitary extramedullary plasmacytoma in primary solitary osseous plasmacytoma. Radiologe 36: 914–920

    Article  PubMed  Google Scholar 

  14. Mancardi GL, Mandybur TI (1983) Solitary intracranial plasmacytoma. Cancer 51: 2226–2233

    Article  PubMed  Google Scholar 

  15. Mantyla R, Kinnunen J, Bohling T (1996) Intracranial plasmacytoma: a case report.Neuroradiology 38: 646–649

    Article  PubMed  Google Scholar 

  16. Nazek M, Mandybur TI, Sawaya R (1988) Hyalinizing plasmacytic granulomatosis of the falx. Am J Surg Pathol 12: 308–213

    PubMed  Google Scholar 

  17. Prasad ML, Mahapatra AK, Kumar L et al. (1994) Solitary intracranial plasmacytoma of the skull base. Indian J Cancer 31: 174–179

    PubMed  Google Scholar 

  18. Rivas L, Guzman JR, Mora-La Cruz E et al. (1994) Extramedullary intracranial solitary plasmacytoma. Report of 2 cases. Invest Clin 35: 155–167

    PubMed  Google Scholar 

  19. Saxena A, Shina S, Tatke M (2000) Intracranial plasma cell granuloma – a case report and review of the literature. Br J Neurosurg 14: 492–495

    Article  PubMed  Google Scholar 

  20. Straube T, Jansen O (2002) Posterior reversible encephalopathy syndrome. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 174: 257–258

    PubMed  Google Scholar 

  21. Vaicys C, Schulder M, Wolansky LJ et al. (1999) Falcotentorial plasmacytoma. Case report. J Neurosurg 91: 132–135

    PubMed  Google Scholar 

  22. Vujovic O, Fisher BJ, Munoz DG (1998) Solitary intracranial plasmacytoma: case report and review of management. J Neurooncol 39: 47–50

    Article  PubMed  Google Scholar 

  23. Weber MA, Viehoever A, Stieltjes B et al. (2005) Intracerebral manifestation of an atypical monoclonal plasma cell hyperplasia depicted by MR perfusion and diffusion tensor imaging as well as MR spectroscopy. AJR Am J Roentgenol 185: 784–787

    PubMed  Google Scholar 

  24. Weidenheim KM, Campbell WG Jr, Goldman HW (1989) Atypical monoclonal plasma cell hyperplasia of the central nervous system: precursor of plasmacytoma with evolutionary considerations. Neurosurgery 24: 429–434

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Abteilung Neurologie, Neurologische Klinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland

    A. Viehöver & B. Wildemann

  2. Abteilung Neuroradiologie, Neurologische Klinik, Universitätsklinikum Heidelberg, Heidelberg, Deutschland

    S. Hähnel

  3. Abteilung Radiologie, Deutsches Krebsforschungszentrum Heidelberg, Heidelberg, Deutschland

    M.-A. Weber

  4. Abteilung Neuropathologie, Pathologisches Institut, Universitätsklinikum Heidelberg, Heidelberg, Deutschland

    S. Zoubaa

  5. Institut für Pathologie, GSF-Forschungszentrum für Umwelt und Gesundheit,GmbH Neuherberg, Neuherberg, Deutschland

    S. Zoubaa

Authors
  1. A. Viehöver
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  2. S. Hähnel
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  3. M.-A. Weber
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  4. S. Zoubaa
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  5. B. Wildemann
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Correspondence to A. Viehöver.

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Viehöver, A., Hähnel, S., Weber, MA. et al. Atypische monoklonale Plasmazellhyperplasie. Nervenarzt 77, 1495–1500 (2006). https://doi.org/10.1007/s00115-006-2223-7

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  • DOI: https://doi.org/10.1007/s00115-006-2223-7

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