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Sind zykloide Psychosen atypische manisch-depressive Erkrankungen?

Ergebnisse einer Familienuntersuchung

Cycloid psychoses as atypical manic-depressive disorders

Results of a family study

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Zusammenfassung

Hintergrund

Zykloide Psychosen (ZP) stellen klinisch sowohl von schizophrenen als auch von affektiven Psychosen abgrenzbare Erkrankungen dar. Bislang fehlen jedoch methodisch befriedigende Daten zur nosologischen Abgrenzbarkeit gegenüber der manisch-depressiven Erkrankung (MDE), weswegen wir hierzu eine kontrollierte Familienstudie durchführten.

Patienten und Methoden

Bei 46 Probanden mit ZP, 33 Probanden mit MDE und 27 Kontrollen wurden insgesamt 356 von 389 lebenden erwachsenen Verwandten 1. Grades von erfahrenen Psychiatern in Unkenntnis des Probandenstatus persönlich untersucht und diagnostiziert.

Ergebnisse

Verwandte von Patienten mit ZP zeigten im Vergleich zu Verwandten von Patienten mit MDE signifikant niedrigere Morbiditätsrisiken für funktionelle Psychosen. Dagegen fand sich bei ZP kein signifikanter Unterschied gegenüber Kontrollen.

Schlussfolgerung

Hereditäre Einflüsse spielen in der Ätiologie von ZP im Gegensatz zur MDE eine untergeordnete Rolle. ZP können anhand dieser Befunde nicht in ein Spektrum bipolarer affektiver Erkrankungen integriert werden.

Summary

Background

Whereas a growing body of evidence suggests that cycloid psychoses have to be separated from schizophrenic psychoses, their relations to bipolar affective disorder are less clear.

Patients and methods

In a controlled family study, we recruited 46 patients with cycloid psychosis (CP), 33 with manic-depressive illness (MDI), and 27 controls. Three hundred fifty-six of 389 living first-degree relatives were personally examined by experienced psychiatrists blinded to the diagnosis of the index proband.

Results

The relatives of CP patients showed significantly lower morbidity risk of functional psychoses than relatives of patients with MDI in Kaplan-Meier life table calculation. The morbidity risk for functional psychoses in relatives of patients with CP did not differ significantly from that in relatives of controls.

Conclusion

These results suggest that CP are etiologically different from bipolar affective psychoses and cannot be integrated into the spectrum of bipolar affective disorders. The findings provide further evidence for a nosological independence of CP.

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Authors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Würzburg

    B. Jabs, G. Althaus, A. Bartsch, A. Schmidtke, G. Stöber, H. Beckmann, E. Franzek & B. Pfuhlmann

  2. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universität Würzburg, Füchsleinstraße 15, 97080, Würzburg, Deutschland

    B. Jabs

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  1. B. Jabs
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  2. G. Althaus
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  5. G. Stöber
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  6. H. Beckmann
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Correspondence to B. Jabs.

Additional information

Diese Studie wurde gefördert mit Mitteln der Erweiterten Forschungsförderung des Freistaates Bayern.

Interessenkonflikt: keiner

Eine überarbeitete Version dieses Beitrags ist hier zu finden: http://dx.doi.org/10.1007/s00115-006-2077-z.

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Jabs, B., Althaus, G., Bartsch, A. et al. Sind zykloide Psychosen atypische manisch-depressive Erkrankungen? . Nervenarzt (2005). https://doi.org/10.1007/s00115-005-1959-9

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