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Emotionale Dysfunktion, Psychopathie und kognitive Neurowissenschaft

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Emotional dysfunction and antisocial personality disorders

A review of findings in cognitive neuroscience

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Zusammenfassung

In diesem Artikel werden die aktuellen Erkenntnisse der kognitiven Neurowissenschaften bei antisozialen Persönlichkeitsstörungen dargestellt. Es zeigt sich, dass sich innerhalb des Spektrums dieser Erkrankungen beim Subtyp der Psychopathie emotionale Dysfunktionen sowohl im Verhalten als auch in strukturellen und funktionellen Aspekten der Hirnorganisation belegen lassen. Zwar sind die Befunde in der Zusammenschau noch sehr heterogen. Dennoch spielen die gewonnenen Erkenntnisse bei den Diskussionen um die Schuldfähigkeit bei Psychopathie faktisch schon heute eine Rolle. Dabei auftretende Fehlschlüsse werden korrigiert, und es wird dafür plädiert, die Diskussion über die Bedeutung emotionaler Faktoren bei der Beurteilung der Schuldfähigkeit zu eröffnen.

Summary

This article provides a review of recent findings in the cognitive neurosciences on antisocial personality disorders. There is accumulating evidence that the subtype of psychopathy is characterized by emotional dysfunction not only on the behavioral level but also by structural and functional abnormalities of the brain. Although the findings are not yet conclusive, they are already being discussed controversially with respect to the question of accountability of persons with psychopathy. False conclusions dominating these considerations are discussed and corrected. The findings open a new discussion of the relevance of emotional function and dysfunction for accountability.

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Literatur

  1. Anderson SW, Bechara A, Damasio H et al. (1999) Impairment of scoial and moral behavior related to early damage in human prefrontal cortex. Nat Neurosci 2:1032–1037

    Article  CAS  PubMed  Google Scholar 

  2. Bechara A (1999) Emotionen und Entscheidungsfindung nach Frontalhirnläsionen: Ansätze zum Verständnis bestimmter psychiatrischer Erkrankungen. Nervenheilkunde 3:1–8

    Google Scholar 

  3. Bechara A, Damasio H, Tranel D et al. (1997) Deciding advantageously before knowing the advantageous strategy. Science 275:1293–1294

    Article  CAS  PubMed  Google Scholar 

  4. Blair J, Sellars C, Strickland I et al. (1996) Theory of Mind in the psychopath. J Forensic Psychiaty 7:15–25

    Google Scholar 

  5. Blair JRJ, Colledge E, Mitchell DGV (2001) Somatic markers and response reversal: is there orbitofrontal cortex dysfunction in boys with psychopathic tendencies? J Abnorm Child Psychol 29:499–511

    Article  CAS  PubMed  Google Scholar 

  6. Blair RJR (1995) A cognitive development approach to morality: investigating the psychopath. Cognition 57:1–29

    Article  CAS  PubMed  Google Scholar 

  7. Blair RJR (2001) Neurocognitive models of aggression, the antisocial personality disorders, and psychopathy. J Neurol Neurosurg Psychiatry 71:727–731

    Article  CAS  PubMed  Google Scholar 

  8. Blair RJR (2003) Neurobiological basis of psychopathy. Br J Psychiatry 182:5–7

    Article  PubMed  Google Scholar 

  9. Blair RJR, Jones L, Clark F et al. (1997) The psychopathic individual: a lack of responsiveness to distress cues? Psychophysiology 34:192–198

    CAS  PubMed  Google Scholar 

  10. Caspi A, Mc’Clay J, Moffitt TE et al. (2002) Role of genotype in the cycle of violence in maltreated children. Science 297:851–854

    Article  CAS  PubMed  Google Scholar 

  11. Damasio A (1994) Descartes Error. Putnams Son, New York

  12. Dinn WM, Harris CL (2000) Neurocognitive function in antisocial personality disorder. Psychiatr Res 97:173–190

    Article  CAS  Google Scholar 

  13. Dolan M, Park I (2002) The neuropsychology of antisocial personality disorder. Psychol Med 32:417–427

    Article  PubMed  Google Scholar 

  14. Farah MJ (2002) Emergin ethical issues in neuroscience. Nat Neurosci 11:1123–1129

    Article  Google Scholar 

  15. Frädrich S, Pfäfflin F (2000) Zur Prävalenz von Persönlichkeitsstörungen bei Strafgefangenen. Recht Psychiatr 18:95–104

    Google Scholar 

  16. Gray NS, MacCulloch MJ, Smith J et al. (2003) Violence viewed by psychopathic murderers. Nature 423:497

    Article  CAS  PubMed  Google Scholar 

  17. Greene J, Haidt J (2002) How (and where) does moral judgement work? Trends Cog Sci 6:517–523

    Article  Google Scholar 

  18. Gross C, Zhuang, X, Stark K et al. (2002) Serotonin1a receptor acts druing development to establish normal anxiety-like behavior in the adult. Nature 416:396–400

    Article  CAS  PubMed  Google Scholar 

  19. Hare RD (1991) The Hare Psychopathy Checklist—Revised. Multi-Health Systems, Toronto

  20. Hare RD (1993) Without conscience. The distrubing world of the psychopaths among us. Guilford Press, New York

  21. Herpertz SC, Sass H (2000) Emotional deficiency and psychopathy. Behav Sci Law 18:567–580

    Article  CAS  PubMed  Google Scholar 

  22. Herpertz SC, Sass H (2003) (Hrsg) Persönlichkeitsstörungen. Thieme, Stuttgart

  23. Herpertz SC, Wenning B, Mueller B et al. (2001) Psychophysiological responses in ADHD children with and without conduct disorder—implications for adult antisocial behavior. J Am Acad Child Adolesc Psychiatry 40(10):1222–1230

    Article  CAS  PubMed  Google Scholar 

  24. Herpertz SC, Werth U, Lukas G et al. (2001) Emotion in criminal offenders with psychopathy and borderline personality disorder. Arch Gen Psychiatry 58:737–745

    Article  CAS  PubMed  Google Scholar 

  25. Intrator J, Hare R, Stritzke P et al. (1997) A brain imaging (single photon emission computerized tomography) study of semantic and affective processing in psychopaths. Biol Psychiatry 42:96–103

    Article  CAS  PubMed  Google Scholar 

  26. Kiehl KA, Smith AM, Hare RD et al. (2001) Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biol Psychiatry 50:677–684

    Article  CAS  PubMed  Google Scholar 

  27. Kiehl KA, Smith AM, Hare RD et al. (2001) An event-related potential investigation of response inhibition in schizophrenia and psychopathy. Biol Psychiatry 48:210–221

    Article  Google Scholar 

  28. Kröber HL, Lau S (2000) Bad or Mad? Personality disorders and legal responsibility—the German situation. Behav Sci Law 18:679–690

    Article  PubMed  Google Scholar 

  29. Laakso MP, Gunning-Dixon Faith, Vaurio O et al. (2002) Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism. Psychiatr Res Neuroimaging 114:95–102

    Article  Google Scholar 

  30. Laakso MP, Vaurio O, Koivisto E et al. (2001) Psychopathy and the posterior hippocampus. Behav Brain Res 118:187–193

    Article  CAS  PubMed  Google Scholar 

  31. LaPierre D, Braun CMJ, Hodgins S (1994) Ventral frontal deficits in psychopathy: neuropsychological test findings. Neuropsychologia 33:139–151

    Article  Google Scholar 

  32. Mealey L (1995) The sociobiology of sociopathy: an integrated evolutionary model. Behav Brain Sci 18:523–541

    Google Scholar 

  33. Mitchell DGV, Colledge E, Leonard A et al. (2002) Risky decisions and response reversal: is there evidence of orbitofrontal cortex dysfunction in psychopathic invividuals? Neuropsychologia 40:2013–2022

    Article  CAS  PubMed  Google Scholar 

  34. Moll J, Oliveira-Souza, Eslinger PJ (2003) Morals and the human brain: a working model. Neuroreport 14:299–305

    Article  PubMed  Google Scholar 

  35. Müller JL, Sommer M, Wagner V et al. (2003) Abnormalities in emotion processing within cortical and subcortical regions in criminal psychopaths. Evidence from an fMRI study using pictures with emotional contents. Biol Psychiatry 54:152–162

    Article  PubMed  Google Scholar 

  36. Raine A (2002) Biosocial studies of antisocial and violent behavior in children and adults: a review. J Abnorm Child Psychol 30:311–326

    Article  PubMed  Google Scholar 

  37. Raine A, Buchsbaum M, LaCasse L (1997) Brain abnormalities in murderes indicated by positron emission tomography. Biol Psychiatry 42:495–508

    Article  CAS  PubMed  Google Scholar 

  38. Raine A, Lencz T, Bihrle S et al. (2000) Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder. Arch Gen Psychiatry 57:119–127

    Article  CAS  PubMed  Google Scholar 

  39. Raine A, Stoddard J, Bihrle S et al. (1998) Prefrontal glucose deficits in murders lacking psychosocial deprivation. Neuropsychiatr Neuropsychol Behav Neurol 11:1–7

    CAS  Google Scholar 

  40. Richell RA, Mitchell DGV, Newman C et al. (2003) Theory of Mind and psychopathy: can psychopathic individuals read the “language of the eyes”? Neuropsychology 41:523–526

    Article  CAS  Google Scholar 

  41. Rolls E (1997) Brain and emotion. Oxford University Press, Oxford

  42. Schmitt WA, Brinkely CA, Newman JP (1999) Testing Damasio’s somatic marker hypothesis with psychopathic individuals: risk taker or risk averse? J Abnorm Psychol 108:538–543

    Article  CAS  PubMed  Google Scholar 

  43. Schneider F, Habel U, Kessler C et al. (2000) Functional imaging of conditioned aversive emotional responses in antisocial personality disorder. Neuropsychobiology 42:192–201

    Article  CAS  PubMed  Google Scholar 

  44. Soderstrom H, Hultin L, Tullberg M et al. (2002) Psychiatr Res Neuroimaging 114:81–94

    Article  Google Scholar 

  45. Stephan A, Walter H (Hrsg) (2003) Natur und Theorie der Emotion. Mentis, Paderborn

  46. Stephan A, Walter H (Hrsg) (2004) Moralität, Rationalität und die Emotionen. Bausteine zur Philosophie, Bd 21. Humboldt-Studienzentrum, Ulm

  47. Tomb I, Hauser M, Celdin P et al. (2002) Do somatic markers mediate decisions on the gambling task? Nat Neurosci 5:1103–1104

    Article  CAS  PubMed  Google Scholar 

  48. Van Honk J, Hermans EJ, Putman P et al. (2002) Defective somatic markers in sub-clinical psychopathy. NeuroReport 13:1025–1027

    PubMed  Google Scholar 

  49. Veit R, Flor H, Erb M et al. (2001) Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neurosci Lett 328:233–236

    Article  Google Scholar 

  50. Walter H (1999) Neurophilosophie der Willensfreiheit, 2. Aufl. Mentis, Paderborn

  51. Walter H (2003) Neurophilosophical perspectives on conservative compatibilism. In: Kanzian C, Quitterer J, Rungaldier E (eds) Persons. An interdisciplinary approach. Proceedings of the 25th International Wittgenstein Symposium. hbt-öbv, Vienna, pp 299–308

  52. Walter H, Wolf CR (2002) Von der Hypofrontalität zur dynamischen Dysfunktion. FMRT-Studien bei Patienten mit Schizophrenie. Nervenheilkunde 21:392–399

    Google Scholar 

  53. Walter H, Wunderlich AP, Blankenhorn M et al. (2003) No hypofrontality, but absence of prefrontal lateralization comparing verbal and spatial working memory in schizophrenia. Schizophr Res 61/2(3):175–184

    Google Scholar 

  54. Wooton JM, Rick PJ, Shelton KK et al. (1997) Ineffective parenting and childhood conduct problems: the moderating role of callous-unemotional traits. J Consult Clin Psychol 65:301–308

    PubMed  Google Scholar 

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Walter, H. Emotionale Dysfunktion, Psychopathie und kognitive Neurowissenschaft . Nervenarzt 76, 557–568 (2005). https://doi.org/10.1007/s00115-004-1817-1

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