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Risikofaktoren des ischämischen Schlaganfalls

Übersicht über die Evidenz in der Primärprävention

Risk in ischemic stroke—review of evidence in primary prevention

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Zusammenfassung

Risikofaktoren sind Merkmale, die mit einem erhöhten Erkrankungsrisiko assoziiert sind. Risikofaktoren haben sowohl in der Primärprävention des ischämischen Schlaganfalls als auch in der klinischen Praxis und der epidemiologischen Forschung eine große Bedeutung. Die zugrunde liegenden Modelle, Methoden und Studiendesigns sind jedoch oft nicht genügend bekannt. Auf der Basis von Interventionsstudien, Kohortenstudien, Fall-Kontroll-Studien und Metaanalysen geben wir in der vorliegenden Arbeit einen aktuellen Überblick über die Primärprävention der wichtigsten etablierten und potenziell beeinflussbaren Risikofaktoren des ischämischen Schlaganfalls. Jeder Risikofaktor wurde nach einem einheitlichen Schema eingeschätzt und systematisch nach Interventionstyp, Evidenzniveau, Risikoreduktion und Prävalenz ausgewertet.

Summary

Risk factors are traits which can increase disease risk. In the case of ischemic stroke, risk factors have important roles in primary prevention, clinical practice, and epidemiological research. However, the underlying models, methods, and suited study design are often unknown. Based on interventions, cohort studies, case control studies, and meta-analyses, we give an up-to-date overall survey of the most important established and modifiable risk factors in the primary prevention of ischemic stroke. Each risk factor was assessed using a uniform pattern and systematically analyzed according to intervention type, evidence level, risk reduction, and prevalence.

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Danksagung

Wir danken Prof. Dr. Wernecke, Institut für medizinische Biometrie der Charité, Prof. Dr. Willich, Institut für Sozialmedizin, Epidemiologie und Gesundheitsökonomie der Charité und Priv.-Doz. Dr. Matthias Endres, Neurologie der Charité für die Unterstützung und kritische Diskussion des Manuskriptes.

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Authors and Affiliations

  1. Studiendekanat, Albert-Ludwigs-Universität Freiburg

    M. Weih

  2. Institut für Sozialmedizin, Epidemiologie und Gesundheitsökonomie, Humboldt-Universität Berlin

    J. Müller-Nordhorn

  3. Neurologische Klinik, Universitätsklinikum Charité, Humboldt-Universität Berlin

    N. Amberger, F. Masuhr, F. Lürtzing & J. P. Dreier

  4. Neurologische Klinik, Albert-Ludwigs-Universität Freiburg

    A. Hetzel

  5. Medizinische Fakultät, Studiendekanat, Elsässerstraße 2m, 79085, Freiburg i.Br.

    M. Weih

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  1. M. Weih
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  2. J. Müller-Nordhorn
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  3. N. Amberger
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  4. F. Masuhr
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  6. J. P. Dreier
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Correspondence to M. Weih.

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Weih, M., Müller-Nordhorn, J., Amberger, N. et al. Risikofaktoren des ischämischen Schlaganfalls. Nervenarzt 75, 324–335 (2004). https://doi.org/10.1007/s00115-003-1639-6

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  • DOI: https://doi.org/10.1007/s00115-003-1639-6

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