Zusammenfassung
In der muskuloskeletalen Tumorchirurgie haben 3D-Druck-Verfahren in den letzten Jahren an Bedeutung gewonnen. Schon vor dem Zeitalter des 3D-Drucks haben sich computergestützte Anwendungen wie die Navigation als hilfreich erwiesen. Aufgrund des variablen Erscheinungsbildes der Erkrankungen besteht der Bedarf an individualisierten Lösungen. Der 3D-Druck kann für die Entwicklung anatomischer Anschauungsmodelle, für die Herstellung patientenindividueller Instrumente und patientenspezifische Implantate zur Anwendung kommen. Für die 3 Einsatzgebiete existieren unterschiedliche regulatorische Hürden. Insbesondere bei der Resektion von Beckentumoren scheinen 3D-Druck-Verfahren Vorteile aufgrund der komplizierten anatomischen Verhältnisse und der Nachbarschaft zu relevanten neurovaskulären Strukturen zu bieten. Die Möglichkeiten des Titandrucks haben das Feld eröffnet, Implantate herzustellen, die sich exakt in entsprechende Defekte einpassen lassen.
Abstract
The importance of 3D printing applications in the surgery of musculoskeletal tumors has increased in recent years. Even prior to the era of 3D printing, computer-assisted techniques, such as navigation, have proved their utility. Due to the variable appearance of bone tumors, there is a need for individual solutions. The 3D printing can be used for the development of anatomical demonstration models, the construction of patient-specific instruments and custom-made implants. For these three applications, different regulatory hurdles exist. Especially for the resection of pelvic tumors, 3D printing technologies seem to provide advantages due to the complicated anatomy and the proximity to relevant neurovascular structures. With the introduction of titanium printing, construction of individualized implants that fit exactly into the defect became feasible.
Literatur
Mumith A, Thomas M, Shah Z, Coathup M, Blunn G (2018) Additive manufacturing current concepts, future trends. Bone Joint J 100B(4):455–460. https://doi.org/10.1302/0301-620X.100B4.BJJ-2017-0662.R2
McCulloch RA, Frisoni T, Kurunskal V, Donati DM, Jeys L (2021) Computer navigation and 3d printing in the surgical management of bone sarcoma. Cells 10(2):1–15. https://doi.org/10.3390/cells10020195
Fujiwara T, Sree DV, Stevenson J, Kaneuchi Y, Parry M, Tsuda Y, Le Nail LR, Medellin RM, Grimer R, Jeys L (2020) Acetabular reconstruction with an ice-cream cone prosthesis following resection of pelvic tumors: Does computer navigation improve surgical outcome? J Surg Oncol. 121(7):1104–1114. https://doi.org/10.1002/jso.25882
Nandra R, Matharu G, Stevenson J, Parry M, Grimer R, Jeys L (2019) Long-term outcomes after an initial experience of computer-navigated resection of primary pelvic and sacral bone tumours: soft-tissue margins must be adequate to reduce local recurrences. Bone Joint J. 101-B(4):484–490. https://doi.org/10.1302/0301-620X.101B4.BJJ-2018-0981.R1
Bosma SE, Cleven AHG, Dijkstra PDS (2019) Can navigation improve the ability to achieve tumor-free margins in pelvic and sacral primary bone sarcoma resections ? A historically controlled study. Clin Orthop Relat Res 477(7):1548–1559. https://doi.org/10.1097/CORR.0000000000000766
Abraham JA, Kenneally B, Bs KA, Geller DS (2018) Can navigation-assisted surgery help achieve negative margins in resection of pelvic and sacral tumors ? Clin Orthop Relat Res 476(3):499–508. https://doi.org/10.1007/s11999.0000000000000064
Shehadeh AM, Isleem U, Abdelal S, Salameh H, Abdelhalim M (2019) Surgical technique and outcome of custom joint-sparing endoprosthesis as a reconstructive modality in juxta-articular bone sarcoma. J Oncol 26;2019:9417284. https://doi.org/10.1155/2019/9417284
Bosma SE, Wong KC, Paul L, Gerbers JG, Jutte PC (2018) A cadaveric comparative study on the surgical accuracy of freehand , computer navigation , and patient-specific instruments in joint-preserving Bone tumor resections. Sarcoma 13;2018:4065846. https://doi.org/10.1155/2018/4065846
Luetke A, Meyers PA, Lewis I, Juergens H (2014) Osteosarcoma treatment—where do we stand? A state of the art review. Cancer Treat Rev 40(4):523–532. https://doi.org/10.1016/j.ctrv.2013.11.006
Jeys LM, Thorne CJ, Parry M, Gaston CLL, Sumathi VP, Grimer JR (2017) A novel system for the surgical staging of primary high-grade osteosarcoma: the birmingham classification. Clin Orthop Relat Res 475(3):842–850. https://doi.org/10.1007/s11999-016-4851-y
Jaffe N, Bruland ØS, Bielack S (2009) Pediatric and adolescent osteosarcoma: editorial summation. Cancer Treat Res 152:573–575. https://doi.org/10.1007/978-1-4419-0284-9
Andreou D, Bielack SS, Carrle D et al (2011) The influence of tumor- and treatment-related factors on the development of local recurrence in osteosarcoma after adequate surgery. An analysis of 1355 patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols. Ann Oncol 22(5):1228–1235. https://doi.org/10.1093/annonc/mdq589
Carrle D, Bielack S (2009) Osteosarcoma lung metastases detection and principles of multimodal therapy. Cancer Treat Res 2009;152:165–84. https://doi.org/10.1007/978-1-4419-0284-9
Errani C, Longhi A, Rossi G et al (2011) Palliative therapy for osteosarcoma. Expert Rev Anticancer Ther 11(2):217–227. https://doi.org/10.1586/era.10.172
Cartiaux O, Docquier P, Paul L et al (2008) Surgical inaccuracy of tumor resection and reconstruction within the pelvis an experimental study. Acta Orthop 79(5):695–702. https://doi.org/10.1080/17453670810016731
Ozaki BT, Flege S, Kevric M et al (2013) Osteosarcoma of the pelvis : experience of the cooperative osteosarcoma study group. J Clin Oncol 21(2):334–341. https://doi.org/10.1200/JCO.2003.01.142
Fuchs B, Hoekzema N, Sim FH (2009) Osteosarcoma of the Pelvis. Clin Orthop Relat Res 467(2):510–518. https://doi.org/10.1007/s11999-008-0495-x
Eggers H, Wichmann J, Omar M, Länger F, Ivanyi P (2021) Onkologische Aspekte der Behandlung pathologischer Frakturen [Oncologic aspects in treatment of pathologic fractures]. Unfallchirurg 124(9):731–737. https://doi.org/10.1007/s00113-021-01051-1
Omar M, Graulich T, Von Falck C, Bruns N (2021) Versorgungsstrategien bei tumorbedingten pathologischen Frakturen der Extremitäten. Unfallchirurg 124(9):704–719. https://doi.org/10.1007/s00113-021-01056-w
Fang C, Cai H, Kuong E et al (2019) Surgical applications of three-dimensional printing in the pelvis and acetabulum: from models and tools to implants. Unfallchirurg 122(4):278–285. https://doi.org/10.1007/s00113-019-0626-8
Garg B, Gupta M, Singh M, Kalyanasundaram D (2019) Outcome and safety analysis of 3D-printed patient-specific pedicle screw jigs for complex spinal deformities: a comparative study. spine J 19(1):56–64. https://doi.org/10.1016/j.spinee.2018.05.001
Hung CC, Li YT, Chou YC et al (2019) Conventional plate fixation method versus pre-operative virtual simulation and three-dimensional printing-assisted contoured plate fixation method in the treatment of anterior pelvic ring fracture. Int Orthop 43(2):425–431. https://doi.org/10.1007/s00264-018-3963-2
Jafary-Zadeh M, Kumar GP, Branicio PS, Seifi M, Lewandowski JJ, Cui F (2018) A critical review on metallic glasses as structural materials for cardiovascular stent applications. J Funct Biomater 9(1):1–32. https://doi.org/10.3390/jfb9010019
Arens S, Hansis M (1996) Titanium implants in accident surgery—when are they necessary? Langenbecks Arch Chir Suppl Kongressbd 113(32):938–940
Schulze M, Gosheger G, Bockholt S et al (2021) Complex bone tumors of the trunk—the role of 3d printing and navigation in tumor orthopedics: A case series and review of the literature. J Pers Med. https://doi.org/10.3390/jpm11060517
Gebert C, Wessling M, Gosheger G et al (2013) Pelvic reconstruction with compound osteosynthesis following hemipelvectomy: a clinical study. Bone Joint J 95 B(10):1410–1416. https://doi.org/10.1302/0301-620X.95B10.31123
Bellanova L, Paul L, Docquier P (2013) Surgical guides ( patient-specific instruments ) for pediatric tibial bone sarcoma resection and allograft reconstruction. Sarcoma 2013:787653. https://doi.org/10.1155/2013/787653
Gouin F, Paul L, Odri GA, Cartiaux O (2014) Instruments for bone tumor resection within the pelvis : a series of 11 patients. Sarcoma 2014:842709. https://doi.org/10.1155/2014/842709
Park JW, Kang HG, Kim JH, Kim HS (2021) The application of 3D-printing technology in pelvic bone tumor surgery. J Orthop Sci 26(2):276–283. https://doi.org/10.1016/j.jos.2020.03.004
Evrard R, Schubert T, Paul L, Docquier P (2019) Resection margins obtained with patient-specific instruments for resecting primary pelvic bone sarcomas : a case-control study. Orthop Traumatol Surg Res 105(4):781–787. https://doi.org/10.1016/j.otsr.2018.12.016
Ji T, Yang Y, Tang X, Liang H, Yan T, Yang R, Guo W (2020) 3D-Printed Modular Hemipelvic Endoprosthetic Reconstruction Following Periacetabular Tumor Resection: Early Results of 80 Consecutive Cases. J Bone Joint Surg Am 102(17):1530–1541. https://doi.org/10.2106/JBJS.19.01437
Swartman B, Franke J, Schnurr C, Märdian S, Willy C, AG Digitalisierung der DGOU; AGiTEC der DGU, Back DA (2020) Digitaler OP [Digital OR]. Unfallchirurg 123(11):849–855. https://doi.org/10.1007/s00113-020-00886-4
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
M. Omar, M. Schulze, N. Bruns, D. Kotrych, G. Gosheger und M. Ettinger geben an, dass kein Interessenkonflikt besteht.
Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.
Additional information
Redaktion
Christian Krettek, Hannover
Die Autoren Mohamed Omar und Martin Schulze teilen sich die Erstautorenschaft.
QR-Code scannen & Beitrag online lesen
Rights and permissions
About this article
Cite this article
Omar, M., Schulze, M., Bruns, N. et al. Update 3D-Druck in der Chirurgie muskuloskeletaler Tumoren. Unfallchirurg 125, 361–370 (2022). https://doi.org/10.1007/s00113-022-01160-5
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00113-022-01160-5
Schlüsselwörter
- Patientenspezifische Modellanfertigung
- Prothesen und Implantate
- Titan
- Sarkome
- Chirurgische Navigationssysteme