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Octreotid zur Chylothoraxtherapie bei 2 Frühgeborenen

Octreotide for the treatment of chylothorax in two preterm infants

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Zusammenfassung

Seit einigen Jahren wird über den Einsatz von Somatostatin (SST) bzw. dessen Analogon Octreotid (OCT) zur Behandlung des therapierefraktären Chylothorax in der Neonatalperiode berichtet. Bezüglich Indikation, Dosierung und Behandlungsdauer existieren keine allgemein anerkannten Therapieschemata. Bei den wenigen bisher berichteten Fällen des Einsatzes bei Frühgeborenen <32 SSW (Schwangerschaftswochen) kam es zu einem Sistieren des Chylusverlustes ohne schwere Nebenwirkungen. Wir beschreiben 2 Frühgeborene [GA („gestational age“) 25 und 27 SSW] mit prolongiertem Chylothorax nach Thorakotomie. Beide Kinder wurden mit OCT (96 µg/kg/Tag) behandelt.

Abstract

In recent years the use of somatostatin (SST) or its analogue octreotide (OCT) has been described for the treatment of refractory chylothorax in neonates. Indication, dose and length of treatment are not precisely defined as yet. To date only few cases of OCT or SST use in preterm infants with a gestational age <32 weeks have been published. Treatment was successful in these patients without serious adverse effects. We report two preterm (gestational age 27 and 25 weeks) infants with chylothorax following surgical ligation of a patent arterial duct. Both patients were treated successfully with OCT (96 µg/kg per day).

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  1. Universitätsklinik für Kinder und Jugendmedizin, Martin-Luther-Universität Halle/Wittenberg, 06097, Halle, Saale, Deutschland

    R. Haase, U. Lieser, S. Buttenhoff & N. Merkel

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  1. R. Haase
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  2. U. Lieser
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  3. S. Buttenhoff
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  4. N. Merkel
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Correspondence to R. Haase.

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Haase, R., Lieser, U., Buttenhoff, S. et al. Octreotid zur Chylothoraxtherapie bei 2 Frühgeborenen. Monatsschr Kinderheilkd 159, 364–367 (2011). https://doi.org/10.1007/s00112-010-2358-2

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  • DOI: https://doi.org/10.1007/s00112-010-2358-2

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