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Genetische Ursachen von Fieberkrämpfen

Genetic causes of febrile seizures

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Zusammenfassung

Genetischen Faktoren kommt bei Fieberkrämpfen eine wichtige Rolle zu. In den letzten Jahren sind verschiedene monogene Epilepsien, bei welchen Fieberkrämpfe einen wichtigen Teil des klinischen Spektrums darstellen, genetisch näher charakterisiert worden. Hierzu gehören die generalisierte Epilepsie mit febrilen Anfällen plus (GEFS+) ebenso wie das Dravet-Syndrom. Auch bei den Temporallappenepilepsien wird ein genetischer Zusammenhang mit dem vorherigen Auftreten von Fieberkrämpfen diskutiert. Der weit überwiegende Teil der Fieberkrämpfe entsteht jedoch nicht aufgrund einer monogenen Ursache, sondern durch verschiedene, ungünstige genetische Faktoren in Kombination mit nichtgenetischen Einflüssen.

Abstract

Genetic factors play an important role in the etiology of febrile seizures. In recent years, genes have been identified for several monogenic epilepsies in which febrile seizures are part of the clinical phenotype. Examples of epilepsies in which syndromic febrile seizures occur are generalized epilepsy with febrile seizures plus (GEFS+) and the Dravet syndrome. In temporal lobe epilepsy a genetic association between a history of febrile seizures and epilepsy is also being discussed. However, most febrile seizures have a polygenic not a monogenic background and are caused by a combination of several different genetic factors with non-genetic causes.

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  1. Institut für Humangenetik , Klinikum der Ludwig-Maximilians-Universität , Goethestraße 29 , 80336 , München , Deutschland

    O. Steinlein

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Steinlein, O. Genetische Ursachen von Fieberkrämpfen. Monatsschr Kinderheilkd 155, 431–436 (2007). https://doi.org/10.1007/s00112-007-1509-6

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  • DOI: https://doi.org/10.1007/s00112-007-1509-6

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