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Lebensqualität in der Blutstammzelltransplantation

Quality of life during blood stem cell transplantation

  • Leitthema
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Zusammenfassung

Für die Bewertung einer Therapiemaßnahme ist die Lebensqualität (LQ) ein wesentlicher Maßstab. Die Blutstammzelltransplantation (BSZT) stellt für viele schwere onkologische und hämatologische sowie einige Immundefekt- und Stoffwechselerkrankungen die einzige Heilungsmöglichkeit dar. Schwere akute Toxizität und erhebliche Spätfolgen können die LQ nach BSZT deutlich einschränken. Die wenigen vorliegenden Studien zur LQ von Kindern nach BSZT beziehen sich ausschließlich auf die Auswirkungen von körperlichen Einschränkungen auf die körperlichen, psychischen und sozialen Funktionen, die so genannte gesundheitsbezogene LQ (HRQOL), Daten zur individuellen LQ fehlen. Die meisten Untersuchungen beschränken sich zudem auf einen Querschnitt einige Monate nach BSZT oder beschäftigen sich mit der späten Adaptation und Wiedereingliederung. Die LQ während der Phase intensiver Therapie und weitgehender Isolation wurde bisher nur selten untersucht, Daten zur LQ von Patienten, die an der Therapietoxizität oder an einem frühen Rezidiv verstarben, fehlen bisher.

Abstract

Quality of life (QOL) is an important measure for every therapeutic intervention. Blood stem cell transplantation (BSCT) is the only curative therapy for many severe neoplastic and hematological diseases and for some immunodeficiencies and inborn errors of metabolism. Severe toxicity and long-term sequelae can significantly impair QOL. The few studies in children after BSCT focus mainly on the impact of somatic impairment on physical, psychological, and social functioning, the so-called health-related QOL. There are no data on subjective QOL. Most studies are cross-sectional ones performed several months after BSCT and deal with late adaptation and reintegration. Data on QOL during intensive therapy and protective isolation are limited and almost nonexistent on patients who died of therapy-related toxicities or early relapse.

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Danksagung

Für hilfreiche Diskussionen und Unterstützung bei der Vorbereitung des Manuskripts bedanke ich mich bei Herrn Prof. Dr. Gian Domenico Borasio und Frau Dr. Barbara Klein (Interdisziplinäres Zentrum für Palliativmedizin der Universität München).

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  1. Dr. von Haunersches Kinderspital, Lindwurmstraße 4, 80337, München

    M. Führer

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Führer, M. Lebensqualität in der Blutstammzelltransplantation. Monatsschr Kinderheilkd 154, 650–656 (2006). https://doi.org/10.1007/s00112-006-1360-1

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