Skip to main content
Log in

Enterale Ernährung von Frühgeborenen

Enteral nutrition of the preterm newborn

  • Leitthema: Das kleine und sehr kleine Frühgeborene
  • Published:
Monatsschrift Kinderheilkunde Aims and scope Submit manuscript

Zusammenfassung

Die wesentliche Ursache für postnatalen Minderwuchs bei Frühgeborenen ist eine unzureichende Ernährung (Energie- und Proteinzufuhr). Infektionen, Inflammationsreaktionen und Medikamente spielen eine untergeordnete Rolle. Postnataler Minderwuchs ist mit geringem Gehirnwachstum, geringer Intelligenz und wahrscheinlich auch mit einem erhöhten Risiko für z. B. Typ-2-Diabetes, koronare Herzerkrankung und Bluthochdruck assoziiert. Er ist ein beeinflussbarer Risikofaktor für eine unzureichende neurokognitive Entwicklung. Ursachen für eine nicht ausreichende frühkindliche Ernährung sind Sicherheitsbedenken. Die parenterale Ernährung wird zu spät gestartet und zu langsam gesteigert; die enterale zu spät begonnen, zu oft abgesetzt und zu langsam gesteigert. Primäres Ziel muss es sein, die fetale Situation einer vollständigen parenteralen Ernährung so schnell wie möglich wiederherzustellen und dann schrittweise auf enterale Ernährung umzustellen. Diese Arbeit gibt einen Überblick über die frühzeitige enterale Ernährung von Frühgeborenen unter besonderer Berücksichtigung von Nährstoffbedarf und Überprüfung von Nahrungsverträglichkeit, Ernährungstechniken und Supplementierung.

Abstract

To a large extent postnatal growth failure is caused by inadequate postnatal nutrition. Postnatal growth failure is associated with poor brain growth, low IQ, coronary heart disease and hypertension. Growth failure is a marker of poor neurocognitive outcome. Owing to safety concerns, parenteral nutrition is started too late and advanced too slowly, and enteral nutrition is started too late, withheld too often and advanced too slowly. The immediate postnatal priority is to reestablish the fetal condition of full parenteral nutrition as fast as possible and gradually introduce enteral nutrition. In the present paper early enteral feeding of preterm infants is reviewed with especial reference to nutritional needs, markers of early feeding tolerance, feeding techniques and supplementation of feeds.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Collin GR (1999) Decreasing catheter colonization through the use of an antiseptic-impregnated catheter: a continuous quality improvement project. Chest 115:1632–1640

    Article  PubMed  Google Scholar 

  2. Dobbing J, Sands J (1979) Comparative aspects of the brain growth spurt. Early Hum Dev 3:79–83

    Article  PubMed  Google Scholar 

  3. Georgieff MK, Hoffman JS, Pereira GR et al. (1985) Effect of neonatal caloric deprivation on head growth and 1-year developmental status in preterm infants. J Pediatr 107:581–587

    PubMed  Google Scholar 

  4. Gross SJ, Oehler JM, Eckerman CO (1983) Head growth and developmental outcome in very low-birth-weight infants. Pediatrics 71:70–75

    PubMed  Google Scholar 

  5. Lucas A, Morley R, Cole TJ (1998) Randomised trial of early diet in preterm babies and later intelligence quotient. BMJ 317:1481–1487

    PubMed  Google Scholar 

  6. Lucas A, Morley R, Cole TJ et al. (1994) A randomised multicentre study of human milk versus formula and later development in preterm infants. Arch Dis Child Fetal Neonatal Ed 70:F141–F146

    PubMed  Google Scholar 

  7. Lucas A, Morley R, Cole TJ et al. (1989) Early diet in preterm babies and developmental status in infancy. Arch Dis Child 64:1570–1578

    PubMed  Google Scholar 

  8. Morley R, Lucas A (2000) Randomized diet in the neonatal period and growth performance until 7.5–8 y of age in preterm children. Am J Clin Nutr 71:822–828

    PubMed  Google Scholar 

  9. Mihatsch WA, Pohlandt F, Koetting K et al. (2004) New and improved population based German reference data for preterm infants growth. Z Geburtshilfe Neonatol 2008:S51

    Google Scholar 

  10. Fee BA, Weil Jr WB (1963) Body composition of infants of diabetic mothers by direct analysis. Ann NY Acad Sci 110:869–897

    PubMed  Google Scholar 

  11. Kelly HJ, Sloan RE, Hoffman W et al. (1951) Accumulation of nitrogen and six minerals in the human fetus during gestation. Hum Biol 23:61–74

    PubMed  Google Scholar 

  12. Widdowson EM, Dickerson JWT (1964) Chemical composition of the body. In: Comar CL, Bronner F (eds) Mineral metabolism. Academic Press, New York, pp 1–247

  13. Widdowson EM, Spray CM (1951) Chemical development in utero. Arch Dis Child 26:205–214

    PubMed  Google Scholar 

  14. Shaw JC (1976) Evidence for defective skeletal mineralization in low-birth weight infants: the absorption of calcium and fat. Pediatrics 57:16–25

    PubMed  Google Scholar 

  15. Kashyap S, Forsynth M, Zucker C et al. (1986) Effects of varying protein and energy intakes on growth and metabolic response in low birth weight infants. J Pediatr 108:955–963

    PubMed  Google Scholar 

  16. Moro G, Fulconis F, Minoli I et al. (1989) Growth and plasma amino acid concentrations in very low birthweight infants fed either human milk protein, fortified human milk or a whey-predominant formula. Acta Paediatr Scand 78:18–22

    PubMed  Google Scholar 

  17. Micheli J-L, Schütz Y (1993) Protein. In: Tsang R, Lucas A, Uauy R et al. (eds) Nutritional needs of the preterm infant, 2nd edn. Williams & Wilkins, Baltimore, pp 29–46

  18. Glass EJ, Hume R, Lang MA et al. (1984) Parenteral nutrition compared with transpyloric feeding. Arch Dis Child 59:131–135

    PubMed  Google Scholar 

  19. Yu VY, James B, Hendry P et al. (1979) Total parenteral nutrition in very low birth weight infants: a controlled trial. Arch Dis Child 54:653–661

    PubMed  Google Scholar 

  20. La Gamma EF, Ostertag SG, Birenbaum H (1985) Failure of delayed oral feedings to prevent necrotizing enterocolitis. Results of study in very-low-birth-weight neonates. Am J Dis Child 139:385–389

    PubMed  Google Scholar 

  21. Ostertag SG, LaGamma EF, Reisen CE et al. (1986) Early enteral feeding does not affect the incidence of necrotizing enterocolitis. Pediatrics 77:275–280

    PubMed  Google Scholar 

  22. Wilson DC, Cairns P, Halliday HL et al. (1997) Randomised controlled trial of an aggressive nutritional regimen in sick very low birthweight infants. Arch Dis Child Fetal Neonatal Ed 77:F4–F11

    PubMed  Google Scholar 

  23. Mihatsch WA, Schoenaich P von, Fahnenstich H et al. (2001) Randomized multi-center trial of two different formulas for very early enteral feeding advancement in extremely low birth weight infants. J Pediatr Gastroenterol Nutr 33:155–159

    Article  PubMed  Google Scholar 

  24. Davey AM, Wagner CL, Cox C et al. (1994) Feeding premature infants while low umbilical artery catheters are in place: a prospective, randomized trial. J Pediatr 124:795–799

    PubMed  Google Scholar 

  25. Mihatsch WA, Hogel J, Pohlandt F (2004) The abdominal circumference to weight ratio increases with decreasing body weight in preterm infants. Acta Paediatr 93:273–274

    Article  PubMed  Google Scholar 

  26. Bhatia P, Johnson KJ, Bell EF (1990) Variability of abdominal circumference of premature infants. J Pediatr Surg 25:543–544

    Article  PubMed  Google Scholar 

  27. Bell MJ, Ternberg JL, Feigin RD et al. (1978) Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg 187:1–7

    PubMed  Google Scholar 

  28. Mihatsch WA, Schoenaich P von, Fahnenstich H et al. (2002) The significance of gastric residuals in the early enteral feeding advancement of extremely low birth weight infants. Pediatrics 109:457–459

    Article  PubMed  Google Scholar 

  29. Mihatsch WA, Franz AR, Högel J et al. (2002) Hydrolyzed protein accelerates feeding advancement in very low birth weight infants. Pediatrics 110:1199–1203

    Article  PubMed  Google Scholar 

  30. Cobb BA, Carlo WA, Ambalavanan N (2004) Gastric residuals and their relationship to necrotizing enterocolitis in very low birth weight infants. Pediatrics 113:50–53

    Article  PubMed  Google Scholar 

  31. Kenton AB, Fernandes CJ, Berseth CL (2004) Gastric residuals in prediction of necrotizing enterocolitis in very low birth weight infants. Pediatrics 113:1848–1849

    Article  PubMed  Google Scholar 

  32. Mihatsch WA, Franz AR, Lindner W et al. (2001) Meconium passage in extremely low birth weight infants and its relation to very early enteral nutrition. Acta Paediatrica 90:409–411

    Article  PubMed  Google Scholar 

  33. Ng PC, So KW, Fung KS et al. (2001) Randomised controlled study of oral erythromycin for treatment of gastrointestinal dysmotility in preterm infants. Arch Dis Child Fetal Neonatal Ed 84:F177–F182

    Article  PubMed  Google Scholar 

  34. Oei J, Lui K (2001) A placebo-controlled trial of low-dose erythromycin to promote feed tolerance in preterm infants. Acta Paediatr 90:904–908

    PubMed  Google Scholar 

  35. Daga SR, Lunkad NG, Daga AS et al. (1999) Orogastric versus nasogastric feeding of newborn babies. Trop Doct 29:242–243

    PubMed  Google Scholar 

  36. McGuire W, McEwan P (2002) Transpyloric versus gastric tube feeding for preterm infants. Cochrane Database Syst Rev 3:CD003487

    Google Scholar 

  37. Schanler RJ, Shulman RJ, Lau C et al. (1999) Feeding strategies for premature infants: randomized trial of gastrointestinal priming and tube-feeding method. Pediatrics 103:434–439

    Article  PubMed  Google Scholar 

  38. Silvestre MAA, Morbach CA, Brans Y et al. (1996) A prospective randomized trial comparing continuous versus intermittent feeding methods in very low birth weight neonates. J Pediatr 128:748–752

    Article  PubMed  Google Scholar 

  39. Macdonald PD, Skeoch CH, Carse H et al. (1992) Randomised trial of continuous nasogastric, bolus nasogastric, and transpyloric feeding in infants of birth weight under 1400 g. Arch Dis Child 67:429–431

    PubMed  Google Scholar 

  40. Akintorin SM, Kamat M, Pildes RS et al. (1997) A prospective randomized trial of feeding methods in very low birth weight infants. Pediatrics 100:E4

    Article  Google Scholar 

  41. Fucile S, Gisel E, Lau C (2002) Oral stimulation accelerates the transition from tube to oral feeding in preterm infants. J Pediatr 141:230–236

    Article  PubMed  Google Scholar 

  42. Kliegman RM (1999) Experimental validation of neonatal feeding practices. Pediatrics 103:492–493

    Article  PubMed  Google Scholar 

  43. Dunn L, Hulman S, Weiner J et al. (1988) Beneficial effects of early hypocaloric enteral feeding on neonatal gastrointestinal function: preliminary report of a randomized trial. J Pediatr 112:622–629

    PubMed  Google Scholar 

  44. McClure RJ, Newell SJ (2000) Randomised controlled study of clinical outcome following trophic feeding. Arch Dis Child Fetal Neonatal Ed 82:F29–F33

    Article  PubMed  Google Scholar 

  45. Meetze WH, Valentine C, McGuigan JE et al. (1992) Gastrointestinal priming prior to full enteral nutrition in very low birth weight infants. J Pediatr Gastroenterol Nutr 15:163–170

    PubMed  Google Scholar 

  46. Slagle TA, Gross SJ (1988) Effect of early low-volume enteral substrate on subsequent feeding tolerance in very low birth weight infants. J Pediatr 113:526–531

    PubMed  Google Scholar 

  47. Troche B, Harvey_Wilkes K, Engle WD et al. (1995) Early minimal feedings promote growth in critically ill premature infants. Biol Neonate 67:172–181

    PubMed  Google Scholar 

  48. Burrin DG, Stoll B, Jiang R et al. (2000) Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: how much is enough? Am J Clin Nutr 71:1603–1610

    PubMed  Google Scholar 

  49. Berseth CL, Bisquera JA, Paje VU (2003) Prolonging small feeding volumes early in life decreases the incidence of necrotizing enterocolitis in very low birth weight infants. Pediatrics 111:529–534

    Article  PubMed  Google Scholar 

  50. Kliegman RM (2003) The relationship of neonatal feeding practices and the pathogenesis and prevention of necrotizing enterocolitis. Pediatrics 111:671–672

    Article  PubMed  Google Scholar 

  51. Engle WD, Lair CS (2004) Early feeding of premature infants questioned. Pediatrics 113:931–932

    Article  PubMed  Google Scholar 

  52. Patole S (2004) Safety of enteral feed volumes in neonates at risk for necrotizing enterocolitis: the never-ending story. Pediatrics 114:327

    Article  Google Scholar 

  53. Menon G, Boyle EM, Embleton ND et al. (2004) Introduction of enteral feeds in preterm infants. Pediatrics 114:327–328

    Article  Google Scholar 

  54. Book LS, Herbst JJ, Jung AL (1976) Comparison of fast- and slow-feeding rate schedules to the development of necrotizing enterocolitis. J Pediatr 89:463–466

    PubMed  Google Scholar 

  55. Caple J, Armentrout D, Huseby V et al. (2004) Randomized, controlled trial of slow versus rapid feeding volume advancement in preterm infants. Pediatrics 114:1597–1600

    Article  PubMed  Google Scholar 

  56. Rayyis SF, Ambalavanan N, Wright L et al. (1999) Randomized trial of slow versus fast feed advancements on the incidence of necrotizing enterocolitis in very low birth weight infants. J Pediatr 134:293–297

    PubMed  Google Scholar 

  57. Schaart MW, Schierbeek H, Schoor SR van der et al. (2005) Threonine utilization is high in the intestine of piglets. J Nutr 135:765–770

    PubMed  Google Scholar 

  58. Cooke RJ, Griffin IJ, McCormick K et al. (1998) Feeding preterm infants after hospital discharge: effect of dietary manipulation on nutrient intake and growth. Pediatr Res 43:355–360

    PubMed  Google Scholar 

  59. Cooke RJ, Embleton ND, Griffin IJ et al. (2001) Feeding preterm infants after hospital discharge: growth and development at 18 months of age. Pediatr Res 49:719–722

    PubMed  Google Scholar 

  60. Lucas A, Fewtrell MS, Morley R et al. (2001) Randomized trial of nutrient-enriched formula versus standard formula for postdischarge preterm infants. Pediatrics 108:703–711

    Article  PubMed  Google Scholar 

  61. Carver JD, Wu PY, Hall RT et al. (2001) Growth of preterm infants fed nutrient-enriched or term formula after hospital discharge. Pediatrics 107:683–689

    Article  PubMed  Google Scholar 

  62. Vochem M, Hamprecht K, Jahn G et al. (1998) Transmission of cytomegalovirus to preterm infants through breast milk. Pediatr Infect Dis J 17:53–58

    Article  PubMed  Google Scholar 

  63. Moody GJ, Schanler RJ, Lau C et al. (2000) Feeding tolerance in premature infants fed fortified human milk. J Pediatr Gastroenterol Nutr 30:408–412

    Article  PubMed  Google Scholar 

  64. Mihatsch WA, Högel J, Pohlandt F (2001) Hydrolyzed protein accelerates the gastro-intestinal transport of formula in preterm infants. Acta Paediatrica 90:196–198

    Article  PubMed  Google Scholar 

  65. Mihatsch WA, Franz AR, Kuhnt B et al. (2004) Hydrolysis of casein accelerates gastrointestinal transit via reduction of opioid receptor agonists released from casein in rats. Biol Neonate 87:160–163

    Article  PubMed  Google Scholar 

  66. Tormo R, Potau N, Infante D et al. (1998) Protein in infant formulas. Future aspects of development. Early Hum Dev 53:S165–S172

    Article  PubMed  Google Scholar 

  67. Rigo J, Senterre J (1994) Metabolic balance studies and plasma amino acid concentrations in preterm infants fed experimental protein hydrolysate preterm formulas. Acta Paediatr 405:98–104

    Google Scholar 

  68. Mihatsch WA, Pohlandt F (1999) Protein hydrolysate formula maintains homeostasis of plasma amino acids in preterm infants. J Pediatr Gastroenterol Nutr 29:406–410

    Article  PubMed  Google Scholar 

  69. Grütte F-K (1984) Prospects and limitations of adjusting cow’s milk formula to human milk with specific consideration of microbiological effects. PhD-thesis, Academy of Science, Berlin, German Democratic Republic

  70. Grütte F-K, Schulze J, Gärtner H et al. (1987) Die mikroökologische Wirkung der Frauenmilch. Nahrung 31:413–419

    PubMed  Google Scholar 

  71. Pohlandt F (1994) Prevention of postnatal bone demineralization in very low-birth-weight infants by individually monitored supplementation with calcium and phosphorus. Pediatr Res 35:125–129

    PubMed  Google Scholar 

  72. Trotter A, Pohlandt F (2002) Calcium and phosphorus retention in extremely preterm infants supplemented individually. Acta Paediatrica 91:680–683

    Article  PubMed  Google Scholar 

  73. Pediatrics AAo (1985) Nutritional needs of low-birth-weight infants. Pediatrics 75:976–986

    PubMed  Google Scholar 

  74. Franz AR, Mihatsch WA, Sander S et al. (2000) Prospective randomized trial of early versus late enteral iron supplementation in infants with a birth weight of less than 1301 grams. Pediatrics 106:700–706

    Article  PubMed  Google Scholar 

  75. Hay WW, Lucas A, Heird WC et al. (1999) Workshop summary: nutrition of the extremely low birth weight infant. Pediatrics 104:1360–1368

    Article  PubMed  Google Scholar 

  76. Tsang R, Uauy R, Koletzko B, Zlotkin S (2005) Nutrition of the preterm infant. 2. ed, Cincinnati: Digital Educational Publishing, Inc

  77. Pohlandt F, Mihatsch WA (2001) Wichtige Aspekte der enteralen Ernährung von sehr kleinen Frühgeborenen. Monatsschr Kinderheilkd 149:S38–S49

    Article  Google Scholar 

  78. Mihatsch WA, Franz AR, Pohlandt F (2002) Frühzeitige enterale Ernährung bei sehr kleinen Frühgeborenen ist nicht mit nekrotisierender Enterokolitis assoziiert. Monatsschr Kinderheilkd 50:724–733

    Article  Google Scholar 

  79. Ziegler EE, Thureen PJ, Carlson SJ (2002) Aggressive nutrition of the very low birthweigth infant. Clin Perinatol 29:225–244

    Article  PubMed  Google Scholar 

Download references

Interessenkonflikt:

Es besteht kein Interessenkonflikt. Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen. Die Präsentation des Themas ist unabhängig und die Darstellung der Inhalte produktneutral.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to W. A. Mihatsch.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mihatsch, W.A., Pohlandt, F. Enterale Ernährung von Frühgeborenen. Monatsschr Kinderheilkd 153, 1165–1171 (2005). https://doi.org/10.1007/s00112-005-1262-7

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00112-005-1262-7

Schlüsselwörter

Keywords

Navigation