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Mögliche Nebenwirkungen einer Hochdosisvalproattherapie

Fallbericht

Possible side effects of high-dose valproate therapy

Case report

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Zusammenfassung

Ein 4 Jahre alter Junge wurde aufgrund einer idiopathischen, primär generalisierten Epilepsie seit 2 Jahren mit Natriumvalproat (VPA) behandelt. Nach bislang guter Verträglichkeit des Medikaments entwickelte er plötzlich eine symptomatische Thrombozytopenie sowie Zeichen einer beginnenden Hepatotoxizität. Diese Nebenwirkungen ließen sich durch eine Reduktion der täglichen VPA-Dosis beherrschen; eine Umstellung der antiepileptischen Therapie wurde nicht notwendig. Gängige Empfehlungen zum Management VPA-induzierter Nebenwirkungen werden vor dem Hintergrund der aktuellen Literatur diskutiert.

Abstract

We report the case of a 4-year-old boy receiving sodium valproate (VPA) therapy since 2 years who suddenly developed clinically relevant thrombocytopenia and signs of hepatotoxicity. Reduction of VPA dosage led to clinical and laboratory improvement, while discontinuation of therapy was not necessary. The current practice of managing VPA-induced side effects is discussed in view of current recommendations from the literature.

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Authors and Affiliations

  1. Reinstorfweg, Hamburg

    G.-M. Lackmann

  2. Reinstorfweg 10a, 21107, Hamburg

    G.-M. Lackmann

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  1. G.-M. Lackmann
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Correspondence to G.-M. Lackmann.

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Lackmann, GM. Mögliche Nebenwirkungen einer Hochdosisvalproattherapie. Monatsschr Kinderheilkd 153, 1101–1102 (2005). https://doi.org/10.1007/s00112-004-0967-3

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  • DOI: https://doi.org/10.1007/s00112-004-0967-3

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