Zusammenfassung
Umweltfaktoren spielen bei der Entstehung von Allergien eine wichtige Rolle. So leiden Bauernkinder weniger häufig an Allergien als ihre Schulkameraden, die nicht auf einem Bauernhof aufwachsen. Je mehr Endotoxin im täglichen Umfeld der Kinder nachweisbar war, desto seltener litten sie an Allergien. In Untersuchungen mit Kindern aus dem gleichen Studienkollektiv konnte ein direkter Effekt von Mikroben in der Umgebung auf das angeborene Immunsystem der Bauernkinder nachgewiesen werden. Die immunologischen Mechanismen, die der Entstehung von Allergien entgegenwirken, sind noch nicht klar. Manches weist darauf hin, dass die Interaktion zwischen Umweltfaktoren, wie z. B. Mikroben, und Genen, die die Antwort des Wirts auf diese Umweltfaktoren beeinflussen, für die Entstehung von allergischen Krankheiten entscheidend ist.
Abstract
Environmental factors play an important role in the pathogenesis of allergies. Farm children suffer from far fewer allergies than their classmates who do not grow up on a farm. The higher the endotoxin concentration in the children's environment was, the less frequently the children were afflicted by allergies. In studies on children from the same trial group, a direct effect of environmental microbes on the immatureimmune system of farmer's children could be demonstrated. The immunological mechanisms that prevent allergies remain unclear. There are some indications that the interaction between environmental factors, e.g., microbes, and genes that influence the response of the host to these environmental factors is decisive in the development of allergic diseases.
Literatur
Akira S, Takeda K, Kaisho T (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2: 675–680
Bach J (2002) The effects of infections on susceptibility to autoimmun and allergic disease. N Engl J Med 347: 911–920
Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, Martinez FD (1999) A polymorphism in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 20: 976–983
Barton G, Medzhitov R (2002) Control of adaptive immune responses by Toll-like receptors. Current Opin Immunol 14: 380–383
Birchler T, Seibl R, Buchner K, Loeliger S, Seger R, Hossle JP, Aguzzi A, Lauener RP (2001) Human Toll-like receptor 2 mediates induction of the antimicrobial peptide human beta-defensin 2 in response to bacterial lipoprotein. Eur J Immunol 31: 3131–3137
Braun-Fahrlander C, Gassner M, Grize L, Neu U, Sennhauser FH, Varonier HS, Vuille JC, Wuthrich B (1999) Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. SCARPOL team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution. Clin Exp Allergy 29: 28–34
Braun-Fahrlander C, Riedler J, Herz U, Eder W, Waser M, Grize L, Maisch S, Carr D, Gerlach F, Bufe A, Lauener RP, Schierl R, Renz H, Nowak D, Mutius E von; Allergy and Endotoxin Study Team (2000) Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 347: 869–877
Braun-Fahrländer C, Lauener RP, Mutius E von (2003) Endotoxin and asthma: Authors' reply. N Engl J Med 348: 173
Braun-Fahrländer C, Lauener RP (in press) Farming and protective agents against allergy and asthma. Clin Exp Allergy in press
Ehrenstein OS von, Mutius E von, Illi S, Baumann L, Bohm O, Kries R von (2000) Reduced risk of hay fever and asthma among children of farmers. Clin Exp Allergy 30: 194–200
Ernst P, Cormier Y (2000) Relative scarcity of asthma and atopy among adolescents raised on a farm. Am J Respir Crit Care Med 161: 1563–1566
Fearon DT, Locksley RM (1996) The instructive role of innate immunity in the acquired immune response. Science 272: 50–53
Flo TH, Halaas O, Torp S, Ryan L, Lien E, Dybdahl B, Sundan A, Espevik T (2001) Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol 69: 474–481
Hoffmann JA, Reichhart J-M (2002) Drosophila innate immunity: an evolutionary perspective. Nat Immunol 3: 121–126
Janeway CJ, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20: 197–216
Kilpelainen M, Terho EO, Helenius H, Koskenvuo M (2000) Farm environment in childhood prevents the development of allergies. Clin Exp Allergy 30: 201–208
Kramer U, Heinrich J, Wjst M, Wichmann HE (1999) Age of entry to day nursery and allergy in later childhood. Lancet 353: 450–454
Lauener RP, Birchler T, Adamski J, Braun-Fahrlander C, Bufe A, Herz U, Mutius E von, Nowak D, Riedler J, Waser M, Sennhauser FH; ALEX study group (2002) Expression of CD14 and Toll-like receptor 2 in farmers' and non-farmers' children. Lancet 360: 465
Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA (2000) A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 68: 6398–6401
Lorenz E, Mira JP, Frees KL, Schwartz DA (2002) Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 162: 1028–1032
Martinez F, Holt P (1999) Role of microbial burden in aetiology of allergy and asthma. Lancet [Suppl] 354: 12–15
Matricardi PM, Rosmini F, Ferrigno L, Nisini R, Rapicetta M, Chionne P, Stroffolini T, Pasquini P, D'Amelio R (1997) Cross sectional retrospecitve study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. BMJ 314: 999–1003
Matricardi PM, Franzinelli F, Franco A, Caprio G, Murru F, Cioffi D, Ferrigno L, Palermo A, Ciccarelli N, Rosmini F (1998) Sibship size, birth order, and atopy in 11371 Italian young men. J Allergy Clin Immunol 101: 439–444
Medzhitov R, Janeway CA (1997) Innate immunity: the virtues of a nonclonal system of recognition. Cell 91: 295–298
Medzhitov R, Janeway CJ (2000) Innate immunity. N Engl J Med 343: 338–344
Mutius E von (2002) Environmental factors influencing the development and progression of pediatric asthma. J Allergy Clin Immunol [Suppl 6] 109: S525–S532
Mutius E von, Braun-Fahrlander C, Schierl R, Riedler J, Ehlermann S, Maisch S, Waser M, Nowak D (2000) Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 30: 1230–1234
Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085–2088
Pugin J, Heumann ID, Tomasz A, Kravchenko VV, Akamatsu Y, Nishijima M, Glauser MP, Tobias PS, Ulevitch RJ (1994) CD14 is a pattern recognition receptor. Immunity 1: 509–516
Riedler J, Eder W, Oberfeld G, Schreuer M (2000) Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clin Exp Allergy 30: 194–200
Riedler J, Braun-Fahrlander C, Eder W, Schreuer M, Waser M, Maisch S, Carr D, Schierl R, Nowak D, Mutius E von; ALEX Study Team (2001) Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 358: 1129–1133
Strachan DP (1989) Hay fever, hygiene, and house-hold size. BMJ 299: 1259–1260
Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443–451
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Lauener, R.P. Allergien: Genetisch determiniertes Schicksal oder durch Umwelteinflüsse bestimmte Krankheit?. Monatsschr Kinderheilkd 151 (Suppl 1), S17–S20 (2003). https://doi.org/10.1007/s00112-003-0815-x
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DOI: https://doi.org/10.1007/s00112-003-0815-x