Abstract
Upon allogeneic transplantation (Tx) of pancreatic islets under the kidney capsule of diabetic rats, cells from draining lymph nodes and, to a minor degree, bone marrow transiently upregulate CD44 splice variants as detected by RT-PCR using CD44 variant exon specific primers. Maximal expression was on day 5 post Tx in lymph nodes and thus precedes islet rejection sufficiently (in this model by 5 days) to still permit establishing rescue by immunosuppressive therapy. CD44 variant exon sequence could therefore serve as early markers of allograft rejection.
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Milde, K., Herrlich, P. & Ponta, H. CD44 splice variants in draining lymph nodes precede allograft rejection of endocrine cells. J Mol Med 77, 67–69 (1999). https://doi.org/10.1007/s001090050303
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DOI: https://doi.org/10.1007/s001090050303