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Pathogenesis of fibrosis: type 1 collagen and the skin


This review on the pathogenesis of fibrosis emphasizes the similarities between tissue repair, a tightly regulated salutary biological response, and fibrosis, an unregulated pathological process. It focuses on the transcriptional regulation of type I collagen, the role of cytokines in fibroblast activation, integrins as examples of cell-matrix signaling pathways, and the heterogeneity of fibroblast populations as factors contributing to fibrosis. Tissue remodeling and the role of matrix metalloproteinases and metalloproteinase inhibitors are mentioned briefly. The capacity of extracellular matrix to modulate cellular function is a recurring theme.

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Received: 17 April 1997 / Accepted: 10 November 1997

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Trojanowska, M., Carwile LeRoy, E., Eckes, B. et al. Pathogenesis of fibrosis: type 1 collagen and the skin. J Mol Med 76, 266–274 (1998).

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  • Key words Fibrosis Collagen
  • type I
  • Transcriptional regulation
  • Cytokines
  • Integrins
  • AbbreviationsAP Activator protein
  • CBF CCAAT binding factor
  • CTGF Connective tissue growth factor
  • ECM Extracellular matrix
  • IL Interleukin
  • MMP Matrix metalloproteinase
  • NF Nuclear factor
  • PDGF Platelet-derived growth factor
  • SSc Systemic sclerosis
  • TGF Transforming growth factor
  • TIMP Tissue inhibitor of metalloproteinase