Abstract
Endothelial cells play a critical role in supporting postnatal hematopoiesis in the bone marrow. Unique endothelial cells, together with various perivascular cells, form different types of vascular structures, constructing a vast microvascular delivery and trafficking network for blood cells, oxygen, and nutrition. These blood vessels build distinct hematopoietic stem and progenitor cell niches, which offer not only sites of residence for blood cells but also indispensable signals directing HSPC homing, self-renewal, and multilineage differentiation. Deep insight into the structure and function of the BM vasculature niche and its participation in hematopoiesis is necessary to develop advanced strategies for the reconstitution of hematopoiesis.
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24 November 2021
A Correction to this paper has been published: https://doi.org/10.1007/s00109-021-02168-x
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This work was not supported by any commercial or financial interests. Research grants were obtained from the following noncommercial foundations: Science and Technology Project of Guangdong Province, Grant/Award Number: 2016A020216027; China Postdoctoral Science Foundation, Grant/Award Number: 2017M612848; Science and Technology Project of Yue-Xiu District of Guangzhou, Grant/Award Number: 2017-WS-004.
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Concept and design: Yan Sun. Drafted or revised the manuscript: Zuohua Chi, Yan Sun. Writing, review, and/or revision of the manuscript: all authors. Study supervision: Yan Sun.
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The original online version of this article was revised: The image of Fig. 1 is modified in the published proof. In the modified image of Fig. 1, the missing "-1" is added and "CD31+Sca-VEGFR2+VEGFR3+ cells (sBMECs) " is corrected to "CD31+Sca-1-VEGFR2+VEGFR3+ cells (sBMECs)". In addition, the image of Fig.1 with improved quality and resolution is provided.
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Chi, Z., Chen, L., Ye, X. et al. The vasculature niches required for hematopoiesis. J Mol Med 100, 53–61 (2022). https://doi.org/10.1007/s00109-021-02155-2
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DOI: https://doi.org/10.1007/s00109-021-02155-2