Correction to: Critical role of interleukin-23 in development of asthma promoted by cigarette smoke

Correction to: Journal of Molecular Medicine

Fig. 1

The expression of IL-23 in lung of mice simultaneously exposed to PBS or Dp and 3 days of cigarette smoke extract (CSE). a Experimental protocol. The expression of IL-23 from lung was detected after instillation of Dp with or without CSE. b The protein level of IL-23 in crushed lung was detected using ELISA. c The expression of IL-23 in lung was detected using immunohistochemistry staining (IHC). d IL-23 IHC quantification. e The expression of IL-23 in lung was detected using immunofluorescence staining (IF, green). *p < 0.05, **p < 0.01

Fig. 2

The evaluation of asthmatic phenotypes in anti-IL-23 Ab-treated mice during sensitization period. a Experimental protocol for house dust mite and cigarette smoke extract induced asthma model of study. b Methacholine hyperresponsiveness was measured 24 h after the last challenge. c The numbers of eosinophils and neutrophils in BALF. d Lung histology after the last challenge (a: PBS, b: CSE, c: Dp, d: Dp/CSE, e: CSE + anti-IL-23 Ab, f: Dp + anti-IL-23 Ab, g: Dp/CSE + anti-IL-23 Ab, H&E stain, × 200). e Serum Dp-specific IgG1 was evaluated after the last challenge. OD, optical density; *p < 0.05; **p < 0.01

Fig. 3

The population of Th2 cells, IL13 + ILC2 after challenge and the numbers of DCs, the level of innate pro-Th2 cytokines after the last sensitization. a–c IL13 or IL5-produced CD4+ T cells and IL13- produced type 2 innate lymphoid cells from lung were evaluated after the last challenge in anti-IL-23 Ab-treated mice during sensitization. After treatment of anti-IL-23 Ab in the sensitization period, mice were sacrificed 24 h after the last sensitization. After sacrifice, lung draining lymph nodes were isolated from mice. d The numbers of MHCII+ CD86+ cells in CD11c + DCs were determined using flow cytometry. e–f The levels of IL-33 and TSLP in the supernatants of crushed lungs were determined using ELISA; *p < 0.05; **p < 0.01

Fig. 4

The expression of IL-23R in lung of mice after sensitization and asthmatic phenotypes after challenge in anti-IL-23R Ab-treated mice during sensitization period. The expression of IL-23R in lung of mice simultaneously exposed to PBS or house dust mite and 3 days of cigarette smoke extract. a The expression of IL-23R in lung was detected using immunohistochemistry staining (IHC). b IL-23R IHC quantification. After treatment of anti-IL-23R Ab in the sensitization period, mice were sacrificed 24 h after the challenge. c Methacholine hyperresponsiveness was measured 24 h after the last challenge. d The number of eosinophils and neutrophils in BALF. *p < 0.05, **p < 0.01

Fig. 5

The population of IL13+ CD4+ Tcells, IL13 + ILC2 after challenge and the numbers of DCs, the level of innate pro-Th2 cytokines after the last sensitization. a Serum Dp-specific IgG1 was evaluated after the last challenge in anti-IL-23R Ab-treated mice during sensitization. b–c IL13- produced CD4+ T cells and IL13-produced type 2 innate lymphoid cell from lung were evaluated after the last challenge in anti-IL-23R Abtreated mice during sensitization. After treatment of anti-IL-23R Ab in the sensitization period, mice were sacrificed 24 h after the last sensitization. After sacrifice, lung draining lymph nodes were isolated from mice. d The numbers of MHCII+ CD86+ cells in CD11c + DCs were determined using flow cytometry. e–f The levels of IL-33 and TSLP in the supernatants of crushed lungs were determined using ELISA. *p < 0.05, **p<0.01

https://doi.org/10.1007/s00109-019-01768-y

The original publication of this paper contains a mistake.

Correct images for figures 1,2, 3, 4 and 5 are shown in this paper.

The original article has been corrected.