Journal of Molecular Medicine

, Volume 91, Issue 8, pp 929–938

Imaging beta-cell mass and function in situ and in vivo


DOI: 10.1007/s00109-013-1056-7

Cite this article as:
Yang, L., Ji, W., Xue, Y. et al. J Mol Med (2013) 91: 929. doi:10.1007/s00109-013-1056-7


Glucose-stimulated insulin secretion (GSIS) from pancreatic beta-cells is critical to the maintenance of blood glucose homeostasis in animals. Both decrease in pancreatic beta-cell mass and defects in beta-cell function contribute to the onset of diabetes, although the underlying mechanisms remain largely unknown. Molecular imaging techniques can help beta-cell study in a number of ways. High-resolution fluorescence imaging techniques provide novel insights into the fundamental mechanisms underlying GSIS in isolated beta-cells or in situ in pancreatic islets, and dynamic changes of beta-cell mass and function can be noninvasively monitored in vivo by imaging techniques such as positron emission tomography and single-photon emission computed tomography. All these techniques will contribute to the better understanding of the progression of diabetes and the search for the optimized therapeutic measures that reverse deficits in beta-cell mass and function.


Imaging Beta-cell In situ In vivo 

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular MedicinePeking University and National Center for Nanoscience and TechnologyBeijingChina
  2. 2.National Laboratory of Biomacromolecules, Institute of BiophysicsChinese Academy of SciencesBeijingChina

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