Journal of Molecular Medicine

, Volume 90, Issue 9, pp 987–996 | Cite as

Etiology of Crohn’s disease: many roads lead to autophagy

  • Pierre Lapaquette
  • Patrick Brest
  • Paul Hofman
  • Arlette Darfeuille-Michaud


Crohn’s disease is a complex multifactor diseases that occur in individuals with genetic predisposition in whom environmental and microbial triggers cause a deleterious chronic immune response. Susceptibility to Crohn’s disease is influenced by common variants at many loci. Genetic studies have emphasized the role of host susceptibility in inflammatory bowel disease onset with the identification of about 100 risk loci, most of which encode proteins involved in immunity, host defense against microbes, and gut homeostasis. In this review, we focus on susceptibility genes related to autophagy in the etiology of Crohn’s disease (CD) and their complex interplay with the gut microbiota, as illustrated by the relationship between immunity-related GTPase family M alleles, microRNA, and xenophagy in CD predisposition.


IBD Crohn’s disease Host susceptibility Autophagy E. coli MicroRNA 



Studies in ADM laboratory are supported by grants from the Ministère de la Recherche et de la Technologie (JE2526, UMR 1071), from Inserm (UMR 1071), from INRA (USC 2018), and from Association F. Aupetit. Studies in PH laboratories were supported by the Institut National du Cancer [07/3D1616/Pdoc-110-32/NG-NC, PL0079, and INFLACOL, the European Community (MICROENVIMET, FP7-HEALTH-F2-2008-201279), and ARC.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Clermont Université, Université d’AuvergneClermont-FerrandFrance
  2. 2.Inserm U1071Clermont-FerrandFrance
  3. 3.INRA, USC2018Clermont-FerrandFrance
  4. 4.Centre Hospitalier UniversitaireClermont-FerrandFrance
  5. 5.IRCAN, INSERM U1081, CNRS UMR 7284, Team 3NiceFrance
  6. 6.Faculté de MédecineUniversité de Nice Sophia AntipolisNiceFrance
  7. 7.Biobank UnitCentre Hospitalo-Universitaire de Nice, Hôpital PasteurNiceFrance
  8. 8.Laboratoire de Pathologie Clinique et ExpérimentaleCentre Hospitalo-Universitaire de Nice, Hôpital PasteurNiceFrance

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