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Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications

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Abstract

Immunologic tolerance is a state of unresponsiveness that is specific for a particular antigen. The immune system has an extraordinary potential for making T cell and B cell that recognize and neutralize any chemical entity and microbe entering the body. Certainly, some of these T cells and B cells recognize self-components; therefore, cellular mechanisms have evolved to control the activity of these self-reactive cells and achieve immunological self-tolerance. The most important in vivo biological significance of mechanisms regulating self-tolerance is to prevent the immune system from mounting an attack against the host’s own tissues resulting in autoimmunity. This review summarizes recent developments in our understanding of T-helper cell tolerance and discusses how the new findings can be exploited to prevent and treat autoimmune diseases, allergy, cancer, and chronic infection, or establish donor-specific transplantation tolerance.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Vassiliki A. Boussiotis

  2. Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Lequn Li & Vassiliki A. Boussiotis

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  1. Lequn Li
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  2. Vassiliki A. Boussiotis
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Correspondence to Vassiliki A. Boussiotis.

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Li, L., Boussiotis, V.A. Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications. J Mol Med 84, 887–899 (2006). https://doi.org/10.1007/s00109-006-0098-5

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  • DOI: https://doi.org/10.1007/s00109-006-0098-5

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