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Doxorubicin toxicity in the Iron Age

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References

  1. Corna G, Galy B, Hentze MW, Cairo G (2006) IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice. J Mol Med http://dx.doi.org/10.1007/s00109-006-0068-y)

  2. Hentze MW, Muckenthaler MU, Andrews NC (2004) Balancing acts: molecular control of mammalian iron metabolism. Cell 117:285–297

    Article  PubMed  CAS  Google Scholar 

  3. Andrews NC (2005) Molecular control of iron metabolism. Best Pract Res Clin Haematol 18:159–169

    Article  PubMed  CAS  Google Scholar 

  4. Pantopoulos K (2004) Iron metabolism and the IRE/IRP regulatory system: an update. Ann N Y Acad Sci 1012:1–13

    Article  PubMed  CAS  Google Scholar 

  5. Xu X, Persson HL, Richardson DR (2005) Molecular pharmacology of the interaction of anthracyclines with iron. Mol Pharmacol 68:261–271

    PubMed  CAS  Google Scholar 

  6. Minotti G, Ronchi R, Salvatorelli E, Menna P, Cairo G (2001) Doxorubicin irreversibly inactivates iron regulatory proteins 1 and 2 in cardiomyocytes: evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor therapy. Cancer Res 61:8422–8428

    PubMed  CAS  Google Scholar 

  7. LaVaute T, Smith S, Cooperman S, Iwai K, Land W, Meyron-Holtz E, Drake SK, Miller G, Abu-Asab M, Tsokos M, Switzer RIII, Grinberg A, Love P, Tresser N, Rouault TA (2001) Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet 27:209–214

    Article  PubMed  CAS  Google Scholar 

  8. Meyron-Holtz EG, Ghosh MC, Iwai K, LaVaute T, Brazzolotto X, Berger UV, Land W, Ollivierre-Wilson H, Grinberg A, Love P, Rouault TA (2004) Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J 23:386–395

    Article  PubMed  CAS  Google Scholar 

  9. El-Demerdash E, Ali AA, Sayed-Ahmed MM, Osman AM (2003) New aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity. Cancer Chemother Pharmacol 52:411–416

    Article  PubMed  Google Scholar 

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  1. Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charité, Humboldt University, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany

    Friedrich C. Luft

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  1. Friedrich C. Luft
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Luft, F.C. Doxorubicin toxicity in the Iron Age. J Mol Med 84, 529–531 (2006). https://doi.org/10.1007/s00109-006-0069-x

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  • DOI: https://doi.org/10.1007/s00109-006-0069-x

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