Skip to main content

Advertisement

Log in

JMM — Past and Present

A clinical protocol for treatment of canine mammary tumors using encapsulated, cytochrome P450 synthesizing cells activating cyclophosphamide: a phase I/II study

  • Published:
Journal of Molecular Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Gordon A (1997) The increasing efficacy of breast cancer treatment. Clin Oncol (R Coll Radiol) 9:338–342

    Article  CAS  Google Scholar 

  2. Genka S, Deutsch J, Stahle PL, Shetty UH, John V, Rapoport SI, Greig NH (1990) Brain and plasma pharmacokinetics and anti-cancer activities of cyclophosphamide and phosphoramide mustard in the rat. Cancer Chemother Pharmacol 27:1–7

    Article  CAS  PubMed  Google Scholar 

  3. Dautzenberg H, Schuldt U, Grasnick G, Karle P, Müller P, Löhr M, Pelegrin M, Piechaczyk M, Von Rombs K, Günzburg WH, Salmons B, Saller RM (1999) Development of cellulose sulphate based polyelectrolyte complex microcapsules for medical applications. Ann NY Acad Sci 875:46–63

    Article  CAS  PubMed  Google Scholar 

  4. Löhr JM, Hoffmeyer A, Kröger J-C, Freund M, Hain J, Holle A, Karle P, Knöfel WT, Liebe S, Müller P, Nizze H, Renner M, Saller RM, Wagner T, Hauenstein K, Günzburg WH, Salmons B (2001) Microencapsulated cell mediated therapy of inoperable pancreatic carcinoma. Lancet 357:1591–1592

    Article  PubMed  Google Scholar 

  5. Kammertöns T, Gelbmann W, Karle P, Saller R, Salmons B, Günzburg WH, Uckert W (2000) Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine. Cancer Gene Ther 7:629–636

    Article  Google Scholar 

  6. Günzburg WH, Karle P, Renz R, Salmons B, Renner M (1999) Characterisation of a human cell clone expressing cytochrome P450 for safe use in human somatic cell therapy. Ann NY Acad Sci 30:880:326–336

    Article  Google Scholar 

  7. Perez Alenza MD, Pena L, Del Castillo N, Nieto AI (2000) Factors influencing the incidence and prognosis of canine mammary tumours. J Small Anim Pract 41:287–291

    Article  CAS  PubMed  Google Scholar 

  8. Brodey RS, Goldschmidt MH, Roszel JR (1983) Canine mammary gland neoplasms. J Am Anim Hosp Assoc 19:61–90

    Google Scholar 

  9. Simon D, Goronzy P, Stephan I, Meyer-Lindenberg A, Aufderheider M, Nolte I (1996) Mammatumoren beim Hund: Untersuchung zu Vorkommen und Verlauf der Erkrankung. Praktische Tierarzt 9:771–782

    Google Scholar 

  10. Kuntze A, Kuntze O (1993) Zur Chirurgie der Mammatumoren bei Hund und Katze. Mh Vet Med 48:467–472

    Google Scholar 

  11. Karayannopoulou M, Kaldrymidou E, Constantinidis TC, Dessiris A (2001) Adjuvant post-operative chemotherapy in bitches with mammary cancer. J Vet Med A Physiol Pathol Clin Med 48:85–96

    Article  CAS  PubMed  Google Scholar 

  12. Löhr M, Müller P, Karle P, Stange J, Mitzner S, Jesenowski R, Nizze H, Nebe B, Liebe S, Salmons B, Günzburg WH (1998) Targeted chemotherapy by encapsulating cells engineered to deliver CYP2B1, an ifosfamide activating cytochrome P450 gene. Gene Ther 5:1070–1078

    Article  PubMed  Google Scholar 

  13. Löhr JM, Bago ZT, Bergmeister H, Ceijka M, Freund M, Gelbmann W, Günzburg, WH, Hain J, Hauenstein K, Henniger W, Hoffmeyer A, Karle P, Kröger J-C, Liebe S, Losert U, Probst A, Renner M, Renz R, Saller R, Salmons B, Schuh M, Wagner T, Walter I (1999) Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting enzyme, instilled intraarterially in patients with advanced stage carcinoma: phase I/II study. J Mol Med 77:393–398

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Winiarczyk, S., Gradski, Z., Kosztolich, B. et al. JMM — Past and Present. J Mol Med 80, 610–614 (2002). https://doi.org/10.1007/s00109-002-0356-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00109-002-0356-0

Keywords

Navigation