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Mikrobiom und metabolisches Syndrom – ein Henne-Ei-Problem?

The microbiome and metabolic syndrome: is this a chicken-or-egg problem?

  • Schwerpunkt: Fettstoffwechsel und Metabolisches Syndrom
  • Published:
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Zusammenfassung

Das Mikrobiom ist hinsichtlich seiner physiologischen und pathophysiologischen Relevanz im letzten Jahrzehnt immer mehr in den Fokus der Forschung gerückt. Erkenntnisgewinne über die Funktionsweise unseres Mikrobioms verdeutlichen dessen Einfluss auf den Metabolismus. Ebenso werden die Wechselwirkungen mit der Entstehung des metabolischen Syndroms offensichtlich, gleichzeitig entstehen aber neue Fragen: Wird das Mikrobiom dysbiotisch, bevor oder nachdem es zu einem pathologischen Stoffwechsel gekommen ist? Gibt es Möglichkeiten, das Darmmikrobiom zur Therapie des metabolischen Syndroms oder seiner Folgeerkrankungen zu nutzen? Ziel dieses Übersichtsbeitrags ist, jenseits des Modebegriffs „Mikrobiom“ über aktuelle Forschungsansätze zu berichten, die auch für den praktisch tätigen Internisten relevant sind.

Abstract

The microbiome has become recognized as a critical player in the understanding of human physiology and pathophysiology, especially with regard to the metabolic syndrome. While recent findings emphasize the impact of the microbiome on metabolic health, new questions simultaneously arise: Is there a dysbiotic microbiome before the onset of metabolic disorders or is dysbiosis caused by a deranged metabolism? Furthermore, are there opportunities to employ the microbiome as a tool for novel treatment strategies in patients with metabolic syndrome? The intention of this review article is to describe the fashionable term “microbiome” beyond its current research approaches, which will be relevant to the practicing internist.

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  1. Klinik für Gastroenterologie, Hepatologie und Transplantationsmedizin, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Deutschland

    Benedikt Hild

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Dagmar Führer-Sakel, Essen

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Hild, B. Mikrobiom und metabolisches Syndrom – ein Henne-Ei-Problem?. Innere Medizin 64, 649–654 (2023). https://doi.org/10.1007/s00108-023-01531-z

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