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Toxoplasma gondii – gegenwärtige Arzneimittel und zukünftige Impfstoffe gegen eine unterschätzte Protozoonose

Toxoplasma gondii—Current drugs and future vaccines against an underestimated protozoan infection

Zusammenfassung

Toxoplasma gondii ist ein weltweit auftretender parasitärer Einzeller der Apicomplexa und somit ein naher Verwandter des Malariaerregers Plasmodium. Da Tgondii zum einen jede warmblütige Wirbeltierart als Zwischenwirt befällt und zum anderen eine weltweit sehr hohe Prävalenz aufweist, gehört die Toxoplasmose zu den international wichtigsten Lebensmittelerkrankungen. Mögliche Impfstoffe (humane wie veterinäre) spielen bei der Kontrolle dieser Erkrankung eine entscheidende Rolle.

Abstract

Toxoplasma gondii is a unicellular organism of the Apicomplexa that occurs worldwide and is therefore a close relative of the malaria pathogen Plasmodium. As Tgondii infests every warm-blooded vertebrate species as an intermediate host and has a very high prevalence worldwide, toxoplasmosis is one of the most important international foodborne diseases. Potential vaccines (human as well as veterinary) play a crucial role in controlling this disease.

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Correspondence to Yannick Borkens MPHTM.

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Borkens, Y. Toxoplasma gondii – gegenwärtige Arzneimittel und zukünftige Impfstoffe gegen eine unterschätzte Protozoonose. Internist 62, 1123–1132 (2021). https://doi.org/10.1007/s00108-021-01155-1

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Schlüsselwörter

  • Lebensmittelerkrankungen
  • One Health
  • Parasiten
  • Toxoplasma-gondii-Impfungen
  • Toxoplasmose

Keywords

  • Foodborne diseases
  • One Health
  • Parasites
  • Toxoplasmosis
  • Vaccines/Toxoplasma gondii