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Pathogenese der chronischen Pankreatitis

Pathogenesis of chronic pancreatitis

Zusammenfassung

Langjähriger Alkoholkonsum und Genmutationen sind die wichtigsten Ursachen einer chronischen Pankreatitis. Neben Mutationen in azinären Genen wie Verdauungsenzymen und deren Inhibitoren sind in den letzten Jahren auch genetische Defekte beschrieben worden, die vornehmlich oder ausschließlich die Gangzellen betreffen. Genveränderungen finden sich nicht nur bei Patienten mit positiver Familienanamnese (hereditäre Pankreatitis), sondern auch bei sogenannter idiopathischer und – in geringerem Maße – bei alkoholischer chronischer Pankreatitis. In den nächsten Jahren wird sich wahrscheinlich zeigen, dass sehr komplexe Interaktionen zwischen Umwelteinflüssen und zahlreichen genetischen Faktoren bestehen.

Abstract

Long-term alcohol consumption and gene mutations are the most important causes of chronic pancreatitis. In addition to mutations in acinar genes, such as digestive enzymes and their inhibitors, defects in genes that primarily or exclusively affect the duct cells have also been described in recent years. Genetic changes are found not only in patients with a positive family history (hereditary pancreatitis) but also in so-called idiopathic and, to a lesser extent, in alcoholic chronic pancreatitis. The coming years will likely show that there are very complex interactions between environmental influences and numerous genetic factors.

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Correspondence to Jonas Rosendahl or Heiko Witt.

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J. Rosendahl und H. Witt geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Markus M. Lerch, München

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Rosendahl, J., Witt, H. Pathogenese der chronischen Pankreatitis. Internist 62, 1007–1014 (2021). https://doi.org/10.1007/s00108-021-01150-6

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Schlüsselwörter

  • Idiopathische Pankreatitis
  • Alkoholabusus
  • Genmutationen
  • Trypsininhibitoren
  • Kalziumstoffwechsel

Keywords

  • Pancreatitis, idiopathic
  • Alcoholism
  • Gene mutations
  • Trypsin inhibitors
  • Calcium metabolism