Zusammenfassung
Obere gastrointestinale Beschwerden sind einer der häufigsten Gründe für die Vorstellung in einer internistisch-hausärztlichen Praxis und stellen den niedergelassenen Hausarzt häufig vor Herausforderungen in der korrekten Diagnosefindung. Neben der Anamneseerhebung und Symptomevaluation ist die körperliche Untersuchung grundsätzlich notwendig, um eine erste Arbeitsdiagnose zu stellen. Daran anschließend sind der Ultraschall des Oberbauchs sowie Laboruntersuchungen essenzielle Werkzeuge für die Differenzialdiagnose.
Abstract
Upper gastrointestinal symptoms are among the most common reasons for medical consultation and represent a challenge for general practitioners in the outpatient care setting. History taking, symptom evaluation and physical examination are the crucial steps toward establishing an initial working diagnosis. The subsequent abdominal ultrasound and laboratory analyses are essential tools for the differential diagnosis.
Literatur
Adedeji OA, McAdam WA (1996) Murphy’s sign, acute cholecystitis and elderly people. J R Coll Surg Edinb 41(2):88–89
AIHW General Practice Statistics and Classification Unit (2004) Presentations of abdominal pain in Australian general practice. Aust Fam Physician 33(12):968–969
Aitken RC (1969) Measurement of feelings using visual analogue scales. Proc R Sic Med 62(10):989–993
Akriviadis EA, Hatzigavriel M, Kapnias D et al (1997) Treatment of biliary colic with diclofenac: a randomized, double-blind, placebo-controlled study. Gastroenterology 113(1):225–231
Andersen CA, Holden S, Vela J et al (2019) Point-of-care ultrasound in general practice: a systemativ review. Ann Fam Med 17(1):61–69
Arienti V, Camaggi V (2011) Clinical applications of bedside ultrasonography in internal and emergency medicine. Intern Emerg Med 6(3):195–201
Bhagra A, Tierney DM, Sekiguchi H, Soni NJ (2016) Point-of-care ultrasonography for primary care physicians and general internists. Mayo Clin Proc 91(12):1811–1827
Becker P, Böttcher KA, Schilling D (2017) Acute abdominal pain. Dtsch Med Wochenschr 142(6):432–441
Brekke M, Eilertsen RK (2009) Acute abdominal pain in general practice: tentative diagnoses and handling. Scand J Prim Health Care 27(3):137–140
Calvert EL, Houghton LA, Cooper P et al (2002) Long-term improvement in functional dyspepsia using hypnotherapy. Gastroenterology 123(6):1778–1785
Carnett JB (1926) Intercostal neuralgia as a cause of abdominal pain and tenderness. Surg Gynecol Obstet 42:625–632
Cartwright SL, Knudson MP (2008) Evaluation of acute abdominal pain in adults. Am Fam Physician 77(7):971–978
Cartwright SL, Knudson MP (2015) Diagnostic imaging of acute abdominal pain in adults. Am Fam Physician 91(7):452–459
Colucciello SA, Lukens TW, Morgan DL (1999) Assessing abdominal pain in adults: a rational cost-effective, and evidence-based strategy. Emerg Med Pract 1:1–20
de Dombal FT (1994) Acute abdominal pain in the elderly. J Clin Gastroenterol 19(4):331–335
DeVon HA, Mirzaei S, Zegre-Hemsey J (2020) Typical and atypical symptoms of acute coronary syndrome: time to retire the terms? J Am Heart Assoc 9(7):e15539
European Association for the Study of the Liver (EASL) (2016) EASL Clinical Practice Guidelines on the prevention, diagnosis and treatment of gallstones. J Hepatol 65(1):146–181
Fischbach W, Malfertsheiner P, Hoffmann JC et al (2009) S3-Leitlinie „Helicobacter pylori und gastroduodenale Ulcuskrankheit“ der deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS). Z Gastroenterol 47:68–102
Ford AC, Delaney BC, Forman D et al (2006) Eradication therapy for peptic ulcer disease in Helicobacter pylori positive patients. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD003840.pub4
Fowler KJ, Therrien JA, Kim DH et al (2018) ACR appropriateness criteria acute nonlocalized abdominal pain. J Am Coll Radiol 15(11):217–231
Fransen GA, Janssen MJ, Muris JW et al (2007) Measuring the severity of upper gastrointestinal complaints: does GP assessment correspond with patients’ self-assessment? Fam Pract 24:252–258
Fröhlich G, Schorn K, Fröhlich H (2020) Dyspnoe – eine Herausforderung in der internistisch-hausärztlichen Praxis. Internist 61:21–35
Gans SL, Pols MA, Stoker J et al (2015) Guideline for the diagnostic pathway in patients with acute abdominal pain. Dig Surg 32(1):23–31
Garg SK, Singh D, Sarvepalli S et al (2019) Incidence, admission rates, and economic burden o adult emergency visits for chronic pancreatitis: data from the national emergency department sample, 2006 to 2012. J Clin Gastroenterol 53(8):328–333
Genc A, Ryk M, Suwala M et al (2016) Ultrasound imaging in the general practitioner’s office—a literature review. J Ultrason 16(64):78–86
Ghaemmaghami CA, Brady WJ (2006) Pitfalls in the emergency department diagnosis of acute myocardial infarction. Emerg Med Clin North Am 19(2):351–369
Gieteling MJ, van Lisman Leeuwen Y, van der Wouden JC et al (2011) Childhood nonspecific abdominal pain in family practice: Incidence, associated factors, and management. Ann Fam Med 9:337–343
Girman CJ, Kou TD, Cai B (2010) Patients with type 2 diabetes mellitus have higher risk for acute pancreatitis compared with those without diabetes. Diabetes Obes Metab 12(9):766–771
Grimpen F, Pavli P (2008) Rational investigation of upper abdominal pain. Aust Fam Phys 37(8):602–607
Gschossmann JM, Holtmann G, Mayer EA (2002) Epidemiology and clinical phenomenology of visceral pain. Schmerz 16(8):447–451
Gschossmann JM, Holtmann G, Netzer P et al (2005) Abdomineller Schmerz. Internist 46(10):1096–1104
Gutt C, Jenssen C, Barreiros AP et al (2018) Aktualisierte S3-Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV) zur Prävention, Diagnostik und Behandlung von Gallensteinen. Z Gastroenterol 56(8):912–966
Gutt C, Schläfer S, Lammert F (2020) The treatment of gallstine disease. Dtsch Arztebl Int 117(9):148–158
Hoffmeister A, Mayerle J, Beglinger C et al (2012) S3-Leitlinie Chronische Pankreatitis: Definition, Ätiologie, Diagnostik, konservative, interventionell endoskopische und operative Therapie derchronischen Pankreatitis. Leitlinie der Deutschen Gesellschaft für Verdauungs-und Stoffwechselkrankheiten (DGVS). Z Gastroenterol 50:1176–1224
Holtmann G, Gschossmann J, Mayer P (2002) A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia. Aliment Pharmacol Ther 16(9):1641–1648
Kamin R, Nowicki TA, Courtney DS et al (2003) Pearls and pitfalls in the emergency department evaluation of abdominal pain. Emerg Med Clin North Am 21:61–72
Katz PO, Gerson LB, Vela MF (2013) Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 108(3):308–328
Keller J, Layer P (2015) Chronischer Oberbauchschmerz: Diagnostischer und therapeutischer Algorithmus. Dtsch Med Wochenschr 140(10):718–722
Kellow ZS, MacInnes M, Kurzencwyg D (2008) The role of abdominal radiography in the evaluaton of the nontrauma emergency patient. Radiology 248(3):887–893
Koop H, Fuchs KH, Labenz J et al (2014) S2k-Leitlinie: Gastroösophageale Refluxkrankheit unter Federführung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS). Z Gastroenterol 52(11):1299–1346
Lameris W, van Randen A, van Es HW et al (2009) Imaging strategies for detection of urgent conditions in patients with acute abdominal pain: diagnostiv accuracy study. BMJ 338:b2431
Lanas A, Carrera-Lasfuentes P, Arguedas Y et al (2015) Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatet agents, or anticoagulants. Clin Gastroenterol Hepatol 13(5):906–912
Lankisch PG, Mahlke R, Lübbers H (2006) Das akute Abdomen aus internistischer Sicht. Dtsch Arztebl Int 103:2178–2188
Lakhoo K, Alnario C, Khalil C et al (2020) Prevalence and characteristics of abdominal pain in the United States. Clin Gastroenterol Hepatol. https://doi.org/10.1016/j.cgh.2020.06.065
Leifeld L, Germer CT, Böhm S et al (2014) S2k-Leitlinie Divertikelkrankheit/Divertikulitis. Z Gastroenterol 52(7):663–710
Ma TT, Yu SY, Li Y et al (2012) Randomized clinical trial: an assessment of acupuncture on specific meridian or specific acupoint vs. sham acupuncture for treating functional dyspepsia. Aliment Pharmacol Ther 35(5):552–561
Manterola C, Vial M, Moraga J et al (2014) Analgesia in patients with acute abdominal pain. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD005660.pub3
Martina B, Bucheli B, Stotz M (1997) First clinical judgment by primary care physicians distinguishes well between nonorganic and organic causes of abdominal or chest pain. J Gen Intern Med 12(1):459–465
Mazzoleni LE, Sander GB, Francesoni CF et al (2011) Helicobacter pylori eradication in functional dyspepsia: HEROES trial. Arch Intern Med 171(21):1929–1936
Melzer J, Rosch W, Reichling J et al (2004) Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW5 (Iberogast). Aliment Pharmacol Ther 20(11–12):1279–1287
Mengel-Jorgensen T, Jensen MB (2016) Variation in the use of point-of-care ultrasound in general practice in various European countries. Results of a survey among experts. Eur J Gen Pract 22(4):274–277
Mitka M (2005) Costly surge in diagnostic imaging spurs debate. JAMA 293(6):665–667
Mjlstad OC, Dalen H, Graven T et al (2012) Routinely adding ultrasound examinations by pocket-sized ultrasound devices improves inpatient diagnostics in a medical department. J Intern Med 23(2):185–191
Neumann FJ, Sousa-Uva M, Ahlsson A et al (2019) 2018 ESC/EACTS Guidelines on myocardial revascularisation. Eur Heart J 40(2):87–165
Niedergethmann M, Post S (2006) Differentialdiagnose des Oberbauchschmerzes. Dtsch Arztebl Int 103(13):862–871
Panebianco NL, Jahnes K, Mills AM (2011) Imaging and laboratory testing in acute abdominal pain. Emerg Med Clin North Am 29(2):175–193
Peura DA, Kovacs TO, Metz DC et al (2004) Lansoprazole in the treatment of functional dyspepsia: two double-blind, randomized, placebo-controlled trials. Am J Med 116(11):740–748
Ponka D, Kirlew M (2007) Top 10 differential diagnoses in family medicine: generalized abdominal pain. Can Fam Physician 53(9):1509
Ralls PW, Halls J, Lapin SA et al (1982) Prospective evaluation of the sonografic Murphy sign in suspected acute cholecystitis. J Clin Ultrasound 10(3):113–115
Richter JE (1991) Dyspepsia: organic causes and differential characteristics from functional dyspepsia. Scand J Gastroenterol Suppl 182:11–16
Roenneberg C, Sattel H, Schaefert R et al (2019) Klinische Leitlinie: Funktionelle Körperbeschwerden. Dtsch Arztebl Int 116:553–560
Schiefke I, Mössner J (2007) Bauchschmerzen. In: Riemann J, Fischbach W, Galle P, Mössner J (Hrsg) Gastroenterologie in Klinik und Praxis. Thieme, Stuttgart, S 47–61
Schiele GM, Pobiruchin M, Weickert U (2020) Internistische Sonographie des Abdomens für Notfallpatienten: Bietet eine vollständige Abdominalsonographie Vorteile? Dtsch Med Wochenschr 145(8):41–49
Seymour CW, Liu VX, Iwashyna TJ (2016) Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315(8):762–774
Sigterman K, van Pinxteren B, Bonis PA et al (2013) Short-term treatment with proton pump inhibitors and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD002095.pub5
Singer M, Deutschman CS, Seymour CW et al (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315(8):801–810
Speets AM, Hoes AW, Graaf Y et al (2006) Upper abdominal ultrasound in general practice: indications, diagnostic yield and consequences for patient management. Fam Pract 23(5):507–511
Tack J, Talley NJ, Camilleri M et al (2006) Functional gastroduodenal disorders. Gastroenterology 130(5):1466–1479
Thistle JL, Cleary PA, Lachin JM et al (1984) The natural history of cholelithiasis: the National Cooperative Gallstone Study. Ann Intern Med 101(2):171–175
Toorenvliet BR, Bakker RFR, Fu HC et al (2010) Standard outpatient re-evaluation for patients not admitted to the hospital after emergency department evaluation for acute abdominal pain. World J Surg 34(3):480–486
Tosetti C, Stanghellini V (1998) Management of dyspepsia in general practice. A critical assessment. PharmacoEconomics 14(2):57–66
Tosetti C, Bellentani S, Benedetto E et al (2010) The management of patients with new onset of upper gastro-intestinal symptoms in primary care. Dig Liver Dis 42(12):860–864
Trede M, Gai H (1986) Which acute abdominal diseases must have urgent surgery? Langenbecks Arch Chir 369:651–657
Udnik MT, Darbha S, Jones J (2013) The diagnosis of acute mesenteric ischemia: a systematic review and meta-analysis. Acad Emerg Med 20(1):1087–1100
Van den Heuvel-Janssen HA, Borghouts JA, Muris JW et al (2006) Chronic non-specific abdominal pain complaints in general practice: a prospective study to management, patient health status and course of compliants. BMC Fam Pract 7:12
Viniol A, Keunecke C, Biroga T et al (2014) Studies of the symptom abdominal pain—a systematic review and metaanalysis. Fam Pract 31(5):517–529
Watanabe T, Fujiwara Y, Chan FK (2020) Current knowledge on non-steroidal anti-inflammatory drug-induced small-bowel damage: a comprehensive review. J Gastroenterol 55(5):481–495
Wübken M, Bühner M, Barth N et al (2015) Welche Aspekte tragen in der täglichen Routine zur diagnostischen Unsicherheit bei? Ergebnisse einer hausärztlichen Befragung. Z Allg Med 91:392–398
Yamamoto W, Kono H, Maekawa H et al (1997) The relationship between abdominal pain regions and specific diseases: an epidemiologic approach to clinical practice. J Epidemiol 7(1):27–32
Yarmish GM, Smith MP, Rosen MP et al (2014) ACR Appropriateness Criteria Right Upper Quadrant Pain. J Am Coll Radiol 11(3):316–322
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G. Fröhlich und H. Fröhlich geben an, dass kein Interessenkonflikt besteht.
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D. Burchert, Mainz
G. Hasenfuß, Göttingen
E. Märker-Hermann, Wiesbaden
J. Mössner, Leipzig
C.C. Sieber, Nürnberg
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Fröhlich, G., Fröhlich, H. Oberbauchschmerz – ein häufiges und facettenreiches Leitsymptom in der internistisch-hausärztlichen Praxis. Internist 62, 3–16 (2021). https://doi.org/10.1007/s00108-020-00917-7
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DOI: https://doi.org/10.1007/s00108-020-00917-7
Schlüsselwörter
- Oberbauchschmerz/Epidemiologie
- Oberbauchschmerz/Differenzialdiagnose
- Abdominalsonographie
- Cholezystitis
- Pankreatitis