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Paraneoplasien der Haut

Paraneoplasms of the skin

  • Schwerpunkt: Paraneoplastische Syndrome
  • Published:
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Zusammenfassung

Paraneoplasien der Haut können sowohl fakultativ als auch obligat mit malignen hämatologischen Erkrankungen oder soliden Tumoren assoziiert sein. Pathophysiologisch kommt es entweder indirekt durch Freisetzung von Wachstumsfaktoren oder Hormonen aus Tumorzellen oder durch eine immunologische Reaktion zu verschiedenen Hautveränderungen. Eine kutane Paraneoplasie kann dabei lokalen oder Allgemeinsymptomen der malignen Erkrankung zeitlich vorausgehen. Richtig erkannt, kann dies zu einer frühen Diagnosestellung und Therapieeinleitung führen und ist folglich von besonderer Bedeutung für Dermatologen und Internisten. Das Auftreten neuer, unerklärbarer oder therapieresistenter Hauterkrankungen sollte daher in interdisziplinärer Zusammenarbeit zu weiteren diagnostischen Schritten führen. Die vorliegende Arbeit gibt einen Überblick über obligate und fakultative paraneoplastische Hauterkrankungen, deren Lokalisation sowie assoziierte hämatologische und solide Neoplasien.

Abstract

The cutaneous manifestations of malignancies include nonmalignant skin disorders that occur in association with malignancies (facultative paraneoplastic dermatoses) and skin disorders that are always associated with hematologic diseases or solid tumors (obligate paraneoplastic dermatoses). Paraneoplastic increase of growth factors or immunological reactions lead to a variety of inflammatory, hyperkeratotic or proliferative skin reactions. When paraneoplastic dermatoses develop before cancer is diagnosed, recognition of these skin diseases can accelerate both the diagnosis and treatment. The presence of unexplained cutaneous findings should lead to a multidisciplinary evaluation of the patient. This manuscript summarizes the cutaneous manifestations associated with hematologic disorders and solid tumors, their localization and treatment options.

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik III, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, München, Deutschland

    C. Gießen-Jung

  2. Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, Ludwig-Maximilians-Universität München, München, Deutschland

    A. Wollenberg &  M. Reinholz

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  1. C. Gießen-Jung
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  2. A. Wollenberg
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  3. M. Reinholz
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Correspondence to C. Gießen-Jung.

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Interessenkonflikt

C. Gießen-Jung, A. Wollenberg und M. Reinholz geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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W. Hiddemann, München

M. Reincke, München

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Gießen-Jung, C., Wollenberg, A. & Reinholz, M. Paraneoplasien der Haut. Internist 59, 134–144 (2018). https://doi.org/10.1007/s00108-017-0372-3

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