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Therapiemanagement bei Malaria

Therapeutic management of malaria

Der Internist volume 52, pages 1407–1413 (2011)Cite this article

Zusammenfassung

Eine Malaria tropica – seltener die anderen Malariaformen – kann rasch zu zerebralen, renalen oder pulmonalen Komplikationen und zu lebensbedrohlichen Verläufen führen. Die Letalität bei schwerer Malaria liegt bei etwa 10%. Bei Fieber nach Tropenaufenthalt muss daher immer differenzialdiagnostisch an eine Malaria gedacht werden. Werden Plasmodien nachgewiesen, muss die Therapie rasch einsetzen – bei schweren Verlaufsformen mit Chinin oder Artesunat. Krankenhäuser sollten ihr Vorgehen bei Patienten mit Malariaverdacht bzw. bei nachgewiesener Malaria in einer Standard Operating Procedure festlegen.

Abstract

Plasmodium falciparum and to some extent malaria caused by other species of Plasmodia can quickly lead to cerebral malaria, acute renal failure, or acute respiratory distress syndrome. The mortality rate for patients with severe malaria lies around 10%. Malaria must be given priority in the differential diagnosis of travelers returning febrile from endemic areas. Treatment requires prompt administration of safe and fast-acting antimalarials, which in severe malaria is treatment with quinine or artesunate. Hospitals must be prepared to diagnose and treat malaria patients—or have a standard operating procedure for transferring the patient to a specialized center.

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Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehungen hin:

Honorare für Vortragstätigkeit von den Firmen Novartis, GSK und Sigma-tau.

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Affiliations

  1. Sektion Tropenmedizin/Infektiologie, I. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Bernhard-Nocht-Straße 74, 20359, Hamburg, Deutschland

    G. Burchard

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  1. G. Burchard
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Correspondence to G. Burchard.

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Burchard, G. Therapiemanagement bei Malaria. Internist 52, 1407–1413 (2011). https://doi.org/10.1007/s00108-011-2928-y

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  • DOI: https://doi.org/10.1007/s00108-011-2928-y

Schlüsselwörter

  • Malaria tropica
  • Malariatherapie
  • Plasmodien
  • Chinin
  • Artesunat

Keywords

  • Falciparum malaria
  • Malaria therapy
  • Plasmodia
  • Quinine
  • Artesunate