Zusammenfassung
Das akute Koronarsyndrom stellt einen Hauptgrund für eine Vorstellung in einer Notaufnahme dar. Darüber hinaus ist das akute Koronarsyndrom mit seinen Komplikationen noch immer die häufigste Todesursache. Beim Begriff „akutes Koronarsyndrom“ handelt es sich jedoch zum einen um den Oberbegriff, welcher die 3 Entitäten „instabile Angina pectoris“, „Nicht-ST-Hebungsinfarkt“ und „ST-Hebungsinfarkt“ zusammenfasst. Zum anderen dient der Begriff vor allem in der Notfallmedizin als Arbeitsdiagnose für Patienten mit (noch) unklarem, akutem Brustschmerz. Obwohl sich die zugrunde liegende Erkrankung nicht geändert hat, wurde insbesondere durch die Einführung der Troponine und die Änderungen des Referenzwerts der Begriff und die Bedeutung des akuten Myokardinfarkts stark verändert. Im vorliegenden Artikel soll die aktuelle Nomenklatur und deren Bedeutung für die adäquate Diagnostik und Therapie weiter erläutert werden.
Abstract
Acute coronary syndrome is one of the most common reasons for a presentation in an emergency room. The biggest component of the overall mortality in adults is acute coronary syndrome or in this context its complications. The term “acute coronary syndrome” comprises on one hand 3 entities – unstable angina pectoris, Non-ST-elevation myocardial infarction and ST-elevation myocardial infarction. On the other hand particularly in emergency medicine the term is used as a working diagnosis for patients with unclear, acute chest pain. Although the underlying disease has not changed, especially with the introduction of troponins and the changes of their reference values the concept and importance of acute myocardial infarction has changed. This article emphazises on the current nomenclature and its importance for the adequate diagnosis and treatment are explained.
Literatur
Antman EM, Cohen M, Radley D et al (1999) Assessment of the treatment effect of enoxaparin for unstable angina/non-Q-wave myocardial infarction. TIMI 11B-ESSENCE meta-analysis. Circulation 100:1602–1608
Bavry AA, Kumbhani DJ, Rassi AN et al (2006) Benefit of early invasive therapy in acute coronary syndromes: a meta-analysis of contemporary randomized clinical trials. J Am Coll Cardiol 48:1319–1325
Breuckmann F, Post F, Giannitsis E et al (2008) Kriterien der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung für „Chest-Pain-Units“. Kardiologe 2:389–394
Cannon CP, Weintraub WS, Demopoulos LA et al; TACTICS (Treat Angina with Aggrastat and Determine Cost of Therapy with an Invasive or Conservative Strategy)--Thrombolysis in Myocardial Infarction 18 Investigators (2001) Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban. N Engl J Med 344:1879–1887
Cheitlin MD, Hutter AM, Brindis RG et al (1999) ACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association. J Am Coll Cardiol 33:273–282
Cross E, How S, Goodacre S (2007) Development of acute chest pain services in the UK. Emerg Med J 24:100–102
de Leon AC, Farmer CA, King Get al (1989) Chest pain evaluation unit: a cost-effective approach for ruling out acute myocardial infarction. South Med J 82:1083–1089
Ferguson JJ, Califf RM, Antman EM et al; SYNERGY Trial Investigators (2004) Enoxaparin vs unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes managed with an intended early invasive strategy: primary results of the SYNERGY randomized trial. JAMA 292:45–54
Fosang AJ, Smith PJ (2001) Human genetics. To clot or not. Nature 413:475–476
Garton M (2006) COMMIT/CCS-2 studies. Lancet 368:642
Gibson RS, Boden WE, Theroux P, et al (1986) Diltiazem and reinfarction in patients with non-Q-wave myocardial infarction. Results of a double-blind, randomized, multicenter trial. N Engl J Med 315:423–429
Goodacre S, Nicholl J, Dixon S et al (2004) Randomised controlled trial and economic evaluation of a chest pain observation unit compared with routine care. BMJ 328:254
Heeschen C, Hamm CW, Goldmann B et al (1999) Troponin concentrations for stratification of patients with acute coronary syndromes in relation to therapeutic efficacy of tirofiban. PRISM Study investigators. Platelet receptor inhibition in ischemic syndrome management. Lancet 354:1757–1762
Keeley EC, Boura JA, Grines CL (2003) Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 361:13–20
Keller T, Zeller T, Peetz D et al (2009) Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 361:868–877
Kugelmass A, Anderson A, Brown P (2004) Does having a chest pain center impact the treatment and survival of acute myocardial infarction patients? Circulation 110:111 (abstract)
Lewis HD, Davis JW, Archibald DG et al (1983) Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a veterans administration cooperative study. N Engl J Med 309:396–403
Libby P (2001) Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 104:365–372
Libby P, Ridker PM, Hansson GK (2009) Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol 54:2129–2138
Lloyd-Jones D, Adams R, Carnethon M, et al.; American Heart Association Statistics Committee and Stroke Statistics Subcommittee.(2009) Heart disease and stroke statistics – 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119:480–486
Mehta SR, Granger CB, Boden WE et al; TIMACS Investigators (2009) Early versus delayed invasive intervention in acute coronary syndromes. N Engl J Med 360:2165–2175
Mehta SR, Yusuf S, Peters RJ et al; Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators (2001) Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 358:527–533
Mizuno K (1992) Angioscopic examination of the coronary arteries: what have we learned? Heart Dis Stroke 1:320–324
Morrow DA, Scirica BM, Karwatowska-Prokopczuk E et al; MERLIN-TIMI 36 Trial Investigators.(2007) Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial. JAMA 297:1775–1783
Ridker PM, Morrow DA, Rose LM et al (2005) Relative efficacy of atorvastatin 80 mg and pravastatin 40 mg in achieving the dual goals of low-density lipoprotein cholesterol <70 mg/dl and C-reactive protein <2 mg/l: an analysis of the PROVE-IT TIMI-22 trial. J Am Coll Cardiol 45:1644–1648
Rouan GW, Hedges JR, Toltzis R et al (1987) A chest pain clinic to improve the follow-up of patients released from an urban university teaching hospital emergency department. Ann Emerg Med 16:1145–1150
Sabatine MS, Cannon CP, Gibson CM et al.; CLARITY-TIMI 28 Investigators (2005) Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med 352:1179–1189
Silber S, Borggrefe M, Böhm M et al (2008) Drug-eluting coronary stents and drug eluting balloon catheters: summary of the position papers of the DGK. Clin Res Cardiol 97:548–563
Silber SBM, Hasenfuß G, Falk V et al (2010) Kommentare zu den Leitlinien der Europäischen Gesellschaft für Kardiologie (ESC) zur Diagnostik und Therapie von Patienten mit ST-Streckenhebungsinfarkt (STEMI). Kardiologe 4:84–92
Tang EW, Wong CK, Herbison P (2007) Global registry of acute coronary events (GRACE) hospital discharge risk score accurately predicts long-term mortality post acute coronary syndrome. Am Heart J 153:29–35
Task Force for Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of European Society of Cardiology; Bassand JP, Hamm CW, Ardissino D et al (2007) Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Eur Heart J 28:1598–1660
Theroux P, Ouimet H, McCans J et al (1988) Aspirin, heparin, or both to treat acute unstable angina. N Engl J Med 319:1105–1111
Thygesen K, Thygesen K, Alpert JS, White HD; Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction et al (2007) Universal definition of myocardial infarction. Circulation 116:2634–2653
Tierney WMFJ, McHenry R et al (1986) Physicians‘ estimates of the probability of myocardial infarction in emergency room patients with chest pain. Med Decis Making 6:12–17
Van de Werf F, Bax J, Betriu A, Blomstrom-Lundqvist C de et al (2008) Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task force on the management of st-segment elevation acute myocardial infarction of the European Society of Cardiology. Eur Heart J 29:2909–2945
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Post, F., Münzel, T. Das akute Koronarsyndrom. Internist 51, 953–962 (2010). https://doi.org/10.1007/s00108-009-2536-2
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DOI: https://doi.org/10.1007/s00108-009-2536-2