Zusammenfassung
Schmerz ist eine der häufigsten Beschwerden, die den Patienten zum Arzt führen. Daher ist die Kenntnis häufiger Schmerzdiagnosen und möglicher Therapieansätze essenziell. Zahlreiche medikamentöse und interventionelle Therapieoptionen stehen in Klinik und Praxis zur Verfügung, um Schmerzerkrankungen kausal und symptomatisch zu behandeln. Chronische neuropathische Schmerzen können wirksam durch Medikamente gelindert werden. Auch interventionelle Verfahren können effektiv in der Schmerztherapie eingesetzt werden, wie die Spinal Cord Stimulation bei therapierefraktärer Angina pectoris. Bei bestimmten Krankheitsbildern (Phantomschmerz, M. Sudeck) sind ergotherapeutische Verfahren (z. B. Spiegeltherapie) sinnvoll. Die konsequente Diagnose und Therapie akuter Schmerzen ist die beste Prophylaxe chronischer Schmerzen.
Abstract
Pain is one of the major complaints leading to doctor visits. Therefore basic knowledge of frequent pain diagnoses and possible treatment approaches is essential. Numerous medical and interventional therapeutic options are available for causal or symptomatic treatment of pain. The treatment of neuropathic pain is often difficult and demands special knowledge. Antidepressants like amitriptyline and anticonvulsive drugs are the first choice in these cases. Also interventional approaches are useful, such as spinal cord stimulation for angina pectoris. For the treatment of complex regional pain syndrome and phantom pain the use of mirror feed-back is a new effective method for pain relief. The only way to prevent from development of chronic pain is the early and effective treatment of acute pain.
Literatur
Ahmedzai S, Brooks D (1997) Transdermal fentanyl versus sustained-release oral morphine in cancer pain: preference, efficacy, and quality of life. J Pain Symptom Manage 13: 254–261
Arnold B, Brinkschmidt T, Casser HR et al. (2009) Multimodale Schmerztherapie: Prinzipien und Indikationen. Schmerz 23: 112–120
Bickel A (2009) Neuropathische Schmerzen – Hilfe für die Therapieauswahl. MMW Fortschr Med 17: 40–44
Börjesson M, Andrell P, Lundberg D, Mannheimer C (2008) Spinal cord stimulation in severe angina pectoris – a systematic review based on the Swedish Council on Technology assessment in health care report on long-standing pain. Pain 140: 501–508
Christo PJ, Mazloomdoost D (2008) Cancer pain and analgesia. Ann N Y Acad Sci 1138: 278–298
Christrup LL, Foster D, Popper LD et al. (2008) Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: a randomized, double-blind, double-dummy, two-way, crossover study. Clin Ther 30: 469–481
Clemens KE, Klaschik E (2008) Management of constipation in palliative care patients. Curr Opin Support Palliat Care 2: 22–27
Coluzzi PH, Schwartzberg L, Conroy JD et al. (2001) Breakthrough cancer pain: a randomized trial comparing oral transmucosal fentanyl citrate and morphine sulfate immediate release. Pain 91: 123–130
Deutscher Bundestag (2003) Antwort des Bundestages auf die Anfrage von Dr. D. Thomae, Detlef Parr und Dr. H.L. Kolb. Drucksache 15/2295 vom 22.12.2003
Eddicks S, Maier-Hauff K, Schenk M et al. (2007) Thoracic spinal cord stimulation improves functional status and relieves symptoms in patients with refractory angina perctoris: the first placebo-controlled randomised study. Heart 93: 585–590
Falowski S, Celli A, Sharan A (2008) Spinal cord stimulation: an update. Neurotherapy 5: 86–99
Frank B, Serpell MG, Hughes J et al. (2008) Comparison of analgesic effects and Patient tolerabilty of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study. BMJ 336: 199–201
Fricke E, Eckert S, Dongas A et al. (2009) Myocardial perfusion after one year of spinal cord stimulation in patients with refractory angina. Nuklearmedizin 48: 104–109
Grötz KA, Diel IJ (2005) Osteonekrose des Kiefers unter Bisphosphonat-Langzeittherapie. Focus Onkologie 3: 52–55
Grond S, Zech D, Diefenbach C et al. (1996) Assessment of cancer pain: a prospective evaluation in 2266 cancer patients referred to a pain service. Pain 64: 107–114
Hans G, Sabatowski R, Binder A et al. (2009) Efficacy and tolerability of a 5% lidocaine medicated plaster for the topical treatment of post-herpetic neuralgia: results of a long-term study. Curr Med Res Opin 25: 1295–1305
Harati Y, Gooch C, Swenson M et al. (1998) Double-blind randomized trial of tramadol for the treatment of the pain of diabetic neuropathy. Neurology 50: 1842–1846
Laverty D (2007) Treating cancer-related breakthrough pain: the oral transmucosal route. Int J Palliat Nurs 13: 326–331
Levick S, Jacobs C, Loukas DF et al. (1988) Naproxen sodium in treatment of bone pain due to metastatic cancer. Pain 35: 253–258
Löwenstein O, Leyendecker P, Hopp M et al. (2009) Combined prolonged-release oxycodone and naloxone improves bowel function in patients receiving opioids for moderate-to-severe non-malignant chronic pain: a randomised controlled trial. Expert Opin Pharmacother 10: 531–543
Moore RA, Moore OA, Derry S et al. (2009) Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trial: bridging a gap between clinical trials and clinical practice. Ann Rheum Dis [Epub ahead of print]
Müller-Schwefe GH, Uberall MA (2008) Analgetischer und muskelrelaxierender Effekt von Flupirtin beim chronischen Rückenschmerz. MMW Fortschr Med 148: 153–161
Mystakidou K, Katsouda E, Parpa E et al. (2005) Oral transmucosal fentanyl citrate for the treatment of breabthrough pain in cancer patients: an overview of its pharmacological and clinical characteristics. J Opioid Manag 1: 36–40
Pfingsten M, Schöps P, Wille T, Terp L (2000) Chronifizierungsausmaß von Schmerzerkrankungen. Schmerz 14: 10–17
Portenoy R, Hagen NA (1990) Breakthrough pain; definition, prevalence, and characteristics. Pain 41: 273–281
Ramachandran VS (2005) Plasticity and functional recovery in neurology. Clin Med 5: 368–373
Reeves RR, Burke RS (2008) Tramadol: basic pharmacology and emerging concepts. Drugs Today 44: 827–836
Reimer K, Hopp M, Zenz M et al. (2009) Meeting the challenges of opioid-induced constipation in chronic pain management – a novel approach. Pharmacology 83: 10–17
Saarto T, Wiffen PJ (2007) Antidepressants for neuropathic pain. Cochrane Database Syst Rev 17: CDOO5454
Schnitzer TJ, Burmester GR, Mysler E et al. (2004) Comparison of Lumeracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gatrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial. Lancet 364: 665–674
Schwarzer A, Glaudo S, Zenz M, Maier C (2007) Spiegeltherapie – eine neues Verfahren in der Therapie neuropathischer Schmerzen. Dtsch Med Wochenschr 132: 2159–2162
Watson CP, Babul N (1998) Efficacy of oxycodone in neuropathic pain: a randomized trial in postherpetic neuralgia. Neurology 50: 1837–1841
Willweber-Strumpf A, Zenz M, Bartz D (2000) Epidemiologie chronischer Schmerzen: Eine Untersuchung in 5 medizinischen Praxen. Schmerz 14: 84–91
Interessenkonflikt
Die korrespondierenden Autoren bestätigen, dass Verbindungen mit den Firmen Grünenthal GmbH, Mundipharma GmbH und Janssen-Cilag GmbH, deren Produkte in dem Artikel genannt werden, bestehen.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Rothstein, D., Zenz, M. Therapie chronischer Schmerzen. Internist 50, 1161–1168 (2009). https://doi.org/10.1007/s00108-009-2474-z
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00108-009-2474-z
Schlüsselwörter
- Chronischer Schmerz
- Tumorschmerztherapie
- Medikamentöse Schmerztherapie
- Neuropathischer Schmerz
- Spiegeltherapie