Skip to main content
Log in

Differenzialdiagnose Dyspnoe

Differential diagnoses of dyspnoea

  • CME Weiterbildung • Zertifizierte Fortbildung
  • Published:
Der Internist Aims and scope Submit manuscript

Zusammenfassung

Dyspnoe (Luftnot) ist ein individuell empfundenes Gefühl, welches durch den Untersucher nicht immer objektivierbar ist. Es handelt sich dabei um qualitativ unterschiedliche Empfindungen mit wechselnder Intensität. Dieses Erleben resultiert aus Interaktionen zwischen vielen verschiedenen physiologischen, psychosozialen und Umweltfaktoren. Die Mechanismen, die zur Dyspnoe führen, sind nicht vollständig verstanden. So existieren Beweise dafür, dass außer den mechanischen Ursachen wie Ventilationsstörungen (Obstruktion, Restriktion), Störungen der Atemmuskeln, knöcherne Deformitäten etc., viele andere Ursachen zu Atemnot führen können. Jede pulmonale oder kardiale Erkrankung führt mit hoher Wahrscheinlichkeit abhängig vom Schweregrad bei Progredienz irgendwann zu Dyspnoe. Ziel dieses Artikels ist es, eine Übersicht über pathophysiologische Mechanismen und Zusammenhänge, zu Diagnostik und Differenzialdiagnosen zu geben.

Abstract

Dyspnoea is a very subjective phenomenon based on the variation in severity for a given degree of functional impairment. It is difficult to grade dyspnoea. Dyspnoea is caused by a variety of physiological, pathophysiological, psychological and environmental factors. The mechanisms leading to dyspnoea are not completely understood. It is known that mechanical reasons like ventilation disturbances (obstruction, restriction), impairment of the ventilation muscles, skeletal deformation and many other reasons can cause dyspnoea. Every pulmonary or cardiac disease may induce dyspnoea depending on the progression of the underlying disease. The aim of this article is to give an overview of basic pathophysiological mechanisms, diagnostic procedures and considerations with regard to possible differential diagnoses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2

Literatur

  1. Adams L, Lane R, Shea SA et al. (1985) Breathlessness during different forms of ventilatory stimulation: a study of mechanisms in normal subjects and respiratory patients. Clin Sci (Lond) 69: 663–672

    Google Scholar 

  2. Altintop L, Yardan T, Cander B et al. (2005) An increase of BNP levels in massive pulmonary embolism and the reduction in response to the acute treatment. Resuscitation 65: 225–229

    Article  PubMed  CAS  Google Scholar 

  3. American Thoracic Society (1999) Dyspnea. Mechanisms, assessment, and management: a consensus statement. Am J Respir Crit Care Med 159: 321–340

    Google Scholar 

  4. Banzett RB, Lansing RW, Brown R et al. (1990) ‚Air hunger‘ from increased PCO2 persists after complete neuromuscular block in humans. Respir Physiol 81: 1–17

    Article  PubMed  CAS  Google Scholar 

  5. Chronos N, Adams L, Guz A (1988) Effect of hyperoxia and hypoxia on exercise-induced breathlessness in normal subjects. Clin Sci (Lond) 74: 531–537

    Google Scholar 

  6. Davie AP, Francis CM, Caruana L et al. (1997) Assessing diagnosis in heart failure: which features are any use? QJM 90: 335–339

    Article  PubMed  CAS  Google Scholar 

  7. DePaso WJ, Winterbauer RH, Lusk JA et al. (1991) Chronic dyspnea unexplained by history, physical examination, chest roentgenogram, and spirometry. Analysis of a seven-year experience. Chest 100: 1293–1299

    Article  PubMed  CAS  Google Scholar 

  8. Elliott MW, Adams L, Cockcroft A et al. (1991) The language of breathlessness. Use of verbal descriptors by patients with cardiopulmonary disease. Am Rev Respir Dis 144: 826–832

    PubMed  CAS  Google Scholar 

  9. Gillespie DJ, Staats BA (1994) Unexplained dyspnea. Mayo Clin Proc 69: 657–663

    PubMed  CAS  Google Scholar 

  10. Hamm CW, Goldmann BU, Heeschen C et al. (1997) Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I. N Engl J Med 337: 1648–1653

    Article  PubMed  CAS  Google Scholar 

  11. Lane R, Cockcroft A, Adams L, Guz A (1987) Arterial oxygen saturation and breathlessness in patients with chronic obstructive airways disease. Clin Sci (Lond) 72: 693–698

    Google Scholar 

  12. Loew PG, Trews G (1962) Die Altersabhängigkeit des arteriellen Sauerstoffdruckes bei der berufstätigen Bevölkerung. Klin Wochenschr 40: 1093–1098

    Article  PubMed  CAS  Google Scholar 

  13. Mahler DA, Faryniarz K, Lentine T et al. (1991) Measurement of breathlessness during exercise in asthmatics. Predictor variables, reliability, and responsiveness. Am Rev Respir Dis 144: 39–44

    PubMed  CAS  Google Scholar 

  14. Manning HL, Schwartzstein RM (1995) Pathophysiology of dyspnea. N Engl J Med 333: 1547–1553

    Article  PubMed  CAS  Google Scholar 

  15. Mathis G, Blank W, Reissig A et al. (2005) Thoracic ultrasound for diagnosing pulmonary embolism: a prospective multicenter study of 352 patients. Chest 128: 1531–1538

    Article  PubMed  Google Scholar 

  16. McBride B, Whitelaw WA (1981) A physiological stimulus to upper airway receptors in humans. J Appl Physiol 51: 1189–1197

    PubMed  CAS  Google Scholar 

  17. Moy ML, Woodrow Weiss J, Sparrow D et al. (2000) Quality of dyspnea in bronchoconstriction differs from external resistive loads. Am J Respir Crit Care Med 162: 451–455

    PubMed  CAS  Google Scholar 

  18. Obata T, Kimura Y, Iikura Y (1992) Relationship between arterial blood gas tensions and a clinical score in asthmatic children. Ann Allergy 68: 530–532

    PubMed  CAS  Google Scholar 

  19. O’Donnell DE, Webb KA (1993) Exertional breathlessness in patients with chronic airflow limitation. The role of lung hyperinflation. Am Rev Respir Dis 148: 1351–1307

    Google Scholar 

  20. Olschewski H, Hoeper MM, Borst MM et al. (2006) [Diagnosis and therapy of chronic pulmonary hypertension]. Pneumologie 60: 749–771

    Article  PubMed  CAS  Google Scholar 

  21. Schwartzstein RM, Lahive K, Pope A et al. (1987) Cold facial stimulation reduces breathlessness induced in normal subjects. Am Rev Respir Dis 136: 58–61

    PubMed  CAS  Google Scholar 

  22. Simon PM, Basner RC, Weinberger SE et al. (1991) Oral mucosal stimulation modulates intensity of breathlessness induced in normal subjects. Am Rev Respir Dis 144: 419–

    PubMed  CAS  Google Scholar 

  23. Simon PM, Schwartzstein RM, Weiss JW et al. (1989) Distinguishable sensations of breathlessness induced in normal volunteers. Am Rev Respir Dis 140: 1021–1027

    PubMed  CAS  Google Scholar 

  24. Simon PM, Schwartzstein RM, Weiss JW et al. (1990) Distinguishable types of dyspnea in patients with shortness of breath. Am Rev Respir Dis 142: 1009–1014

    PubMed  CAS  Google Scholar 

  25. Spence DP, Graham DR, Ahmed J et al. (1993) Does cold air affect exercise capacity and dyspnea in stable chronic obstructive pulmonary disease? Chest 103: 693–

    Article  PubMed  CAS  Google Scholar 

  26. Taguchi O, Kikuchi Y, Hida W et al. (1991) Effects of bronchoconstriction and external resistive loading on the sensation of dyspnea. J Appl Physiol 71: 2183–2190

    PubMed  CAS  Google Scholar 

  27. Wells PS, Anderson DR, Rodger M et al. (2003) Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med 349: 1227–1235

    Article  PubMed  CAS  Google Scholar 

  28. Yardan T, Altintop L, Baydin A et al. (2007) B-type natriuretic peptide as an indicator of right ventricular dysfunction in acute pulmonary embolism. Int J Clin Pract [Epub ahead of print]

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A.R. Koczulla.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Koczulla, A. Differenzialdiagnose Dyspnoe. Internist 48, 1389–1400 (2007). https://doi.org/10.1007/s00108-007-1976-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00108-007-1976-9

Schlüsselwörter

Keywords

Navigation