Zusammenfassung
Das ektope ACTH-Syndrom stellt eine seltene Differenzialdiagnose der hypokaliämischen Hypertonie dar. Patienten mit einem ektopen ACTH-Syndrom infolge eines kleinzelligen Bronchialkarzinoms haben eine ungünstige Prognose. Wir berichten über eine 68-jährige Patientin, die sich mit Dyspnoe und einer hypokaliämischen Hypertonie vorstellte. Die endokrine Abklärung ergab ein ektopes ACTH-Syndrom infolge eines kleinzelligen Bronchialkarzinoms. Nach Beginn der Chemotherapie mit Etoposid und Carboplatin normalisierten sich die ACTH- und Kortisolspiegel, und die klinische Symptomatik verbesserte sich eindrucksvoll.
Abstract
Ectopic ACTH syndrome is a rare differential diagnosis of hypokalemic hypertension. Patients with ectopic ACTH syndrome due to small cell lung cancer have a poor prognosis. We report on a 68-year-old female patient who presented with dyspnea and hypokalemic hypertension. Endocrine testing was consistent with ectopic ACTH syndrome due to small cell lung cancer. After initiation of chemotherapy with etoposide and carboplatin ACTH and cortisol levels normalized and clinical symptoms impressively improved.
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Müssig, K., Maser-Gluth, C., Hartmann, M. et al. 68-jährige Patientin mit Dyspnoe und hypokaliämischer Hypertonie. Internist 48, 1145–1150 (2007). https://doi.org/10.1007/s00108-007-1930-x
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DOI: https://doi.org/10.1007/s00108-007-1930-x
Schlüsselwörter
- Hypokaliämie
- Cushing-Syndrom
- Ektopes ACTH-Syndrom
- Kleinzelliges Bronchialkarzinom
- Kortisol
- 11-β-Hydroxysteroiddehydrogenase