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Pathogenese der COPD

Pathogenesis of chronic obstructive pulmonary disease

  • Schwerpunkt: COPD
  • Published:
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Zusammenfassung

Nach gegenwärtigem Verständnis steht im Zentrum der Pathogenese der chronisch obstruktiven Lungenerkrankung (COPD) eine Entzündung im Bereich der kleinen Atemwege, die durch inhalierte Partikel und Gase ausgelöst wird. Im Zusammenhang damit kommt es zu einer Störung des physiologischen Gleichgewichts zwischen Proteasen und Proteaseinhibitoren, die im kausalen Zusammenhang mit der Ausbildung eines Lungenemphysems gesehen wird. Daneben scheint oxidativer Stress, der die Entzündung steigern kann, von Bedeutung zu sein. Darüber hinaus wird diskutiert, dass der Verlust von Alveolarzellen durch Apoptose zur Emphysembildung beitragen kann. Schließlich gibt es zahlreiche Anhaltspunkte für eine durch die COPD ausgelöste Entzündung, die für die systemischen Komponenten der Erkrankung zumindest mitverantwortlich sein könnte.

Abstract

It is currently believed that the most important factor in the pathogenesis of chronic obstructive pulmonary disease (COPD) is inflammation of the small airways caused by inhaled particles and gases. In this context, a disturbance of the physiological balance between proteases and antiproteases develops that may cause lung emphysema. Moreover, oxidative stress seems to be important, as it may enhance the inflammatory reaction. The development of emphysema may also involve a loss of alveolar cells by apoptosis. Finally, several studies have indicated that a systemic inflammation is induced by COPD that may be of relevance to the development of systemic components that are observed in COPD patients.

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Authors and Affiliations

  1. Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Universitätsklinikum Gießen und Marburg – Standort Marburg, Baldingerstraße, 35043 , Marburg

    C. Vogelmeier, R. Koczulla, H. Fehrenbach & R. Bals

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  1. C. Vogelmeier
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  2. R. Koczulla
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  3. H. Fehrenbach
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  4. R. Bals
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Correspondence to C. Vogelmeier.

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Vogelmeier, C., Koczulla, R., Fehrenbach, H. et al. Pathogenese der COPD. Internist 47, 885–894 (2006). https://doi.org/10.1007/s00108-006-1691-y

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  • DOI: https://doi.org/10.1007/s00108-006-1691-y

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