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Microarray-basierte Transkriptomanalysen bei Infektionskrankheiten

Ein neuer diagnostischer Weg

Microarray-based transcriptome analyses in infectious diseases

A new diagnostic method

  • Individualisierte Therapie – ein Paradigmenwechsel?
  • Published:
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Zusammenfassung

Die komplexe Interaktion zwischen einem Erreger und einem Wirt ist die molekulare Grundlage für eine Infektionskrankheit. Die Microarray-Technologie bietet über die Analyse des Transkriptoms ideale Möglichkeiten, diesen Dialog zwischen Erreger und Wirt zu untersuchen. Die Erkenntnisse aus der Entschlüsselung der molekularen Details dieser Interaktionen werden zur Identifizierung und Charakterisierung von virulenzassoziierten Genen des Erregers und Abwehrstrategien des Wirtes führen. Diese Informationen haben das gewaltige Potenzial, unser Verständnis der molekularen Pathogenese von Infektionskrankheiten zu vertiefen und neue Möglichkeiten der Diagnostik, Behandlung, Prognostik und Prävention dieser Erkrankungen zu eröffnen.

Abstract

The complex interaction between a pathogen and a host is the molecular basis of infectious diseases. Microarray technology is a powerful tool to investigate the crosstalk between pathogen and the host as it assesses whole genome expression profiles in response to disease. Deciphering the molecular details on both sides of the host-pathogen interaction will increase our understanding of the pathogenesis of infectious diseases and offer improvements in their diagnosis, treatment, prognosis, and prevention.

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Danksagung

Wir danken Herrn PD Dr. Eugen Domann und Herrn Andre Brillon für hilfreiche Diskussionen und die kritische Durchsicht dieser Übersichtsarbeit.

Das dieser Arbeit zugrunde liegende Vorhaben wurde im Rahmen des Nationalen Genomforschungsnetzes NGFN mit Mitteln des Bundesministeriums für Bildung und Forschung unter dem Förderkennzeichen 01GS0401 gefördert. Die Verantwortung für den Inhalt dieser Veröffentlichung liegt beim Autor.

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  1. Institut für Medizinische Mikrobiologie, Frankfurter Straße 107, 35392 , Gießen

    H. Hossain & T. Chakraborty

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  1. H. Hossain
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  2. T. Chakraborty
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Correspondence to H. Hossain.

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Hossain, H., Chakraborty, T. Microarray-basierte Transkriptomanalysen bei Infektionskrankheiten. Internist 47 (Suppl 1), S6–S13 (2006). https://doi.org/10.1007/s00108-006-1627-6

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  • DOI: https://doi.org/10.1007/s00108-006-1627-6

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