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82-jährige Patientin mit Hyperostosis frontalis, Prognathie, Makroglossie und Cutis gyrata

82-year old patient with hyperostosis frontalis, prognathism, makroglossia and cutis gyrata

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Zusammenfassung

Wir stellen eine 82-jährige Patientin mit einem typischen, offenbar seit Jahrzehnten bestehenden akromegalen Phänotyp vor. Zeichen der Organvergrößerung waren nicht zu erheben. Im MRT stellte sich ein Makroadenom der Hypophyse dar. Der orale Glukosetoleranztest zeigte die typische fehlende Suppression des Wachstumshormons (GH). Die GH-Suppression gelang dagegen mit einem langwirksamen Somatostatinanalogon. Eine weitere signifikante klinische und laborchemische Affektion der Hypophyse war nicht festzustellen. Eine GH-suppressive Therapie mit einem langwirksamen Dopaminagonisten (Cabergolin) wurde eingeleitet. Ein Jahr nach Therapiebeginn verstarb die Patientin an einem kardiovaskulären Ereignis.

Abstract

We present a 82 year old female patient with typical acral enlargement. There were no signs of visceromegaly. Magnetic resonance imaging of the pituitary region showed a macroadenoma. Oral glucose tolerance test revealed missing suppression of the Human Growth Hormone (HGH), which could be achieved with a long acting somatostatin analog. A HGH suppressive therapy with a long acting dopamine agonist (Cabergolin) was induced. The patient died one year later following cardiovascular complications.

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Authors and Affiliations

  1. Abteilung Innere Medizin I, Sektion Endokrinologie, Universitätsklinikum Ulm

    H. Mönnich,  B. O. Böhm & H. Weidenbach

  2. Abteilung Innere Medizin I, Universitätsklinikum, Robert-Koch-Straße 8, 89081 , Ulm

    B. O. Böhm

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  1. H. Mönnich
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  2. B. O. Böhm
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  3. H. Weidenbach
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Correspondence to B. O. Böhm.

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Mönnich, H., Böhm, B.O. & Weidenbach, H. 82-jährige Patientin mit Hyperostosis frontalis, Prognathie, Makroglossie und Cutis gyrata. Internist 45, 815–819 (2004). https://doi.org/10.1007/s00108-004-1194-7

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  • DOI: https://doi.org/10.1007/s00108-004-1194-7

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