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Konventionelles und molekulares Screening (Stuhltests)

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Der fäkale okkulte Bluttest gehört seit Ende der 1970er Jahre zum Programm der gesetzlichen Krebsfrüherkennung in Deutschland. Der Nutzen des fäkalen Bluttests in der Früherkennung kolorektaler Karzinome konnte in mehreren großen, randomisierten Studien nachgewiesen werden. Er ist in seiner Wertigkeit aufgrund einer mäßigen Sensitivität jedoch begrenzt. Endoskopische Screeningmethoden sind zur Detektion von Adenomen und Karzinomen zwar deutlich sensitiver, jedoch auch invasiver. Genetische Stuhltests könnten zukünftig eine alternative Screeningstrategie mit hoher Spezifität und Sensitivität bei geringer Invasivität darstellen.

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Authors and Affiliations

  1. Medizinische Klinik, Knappschaftskrankenhaus, Ruhr-Universität Bochum

    C. Pox, K. Schulmann &  W. Schmiegel

  2. Medizinische Klinik, Knappschaftskrankenhaus, Ruhr-Universität Bochum, In der Schornau 23–25, 44892, Bochum

    W. Schmiegel

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  1. C. Pox
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  2. K. Schulmann
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  3. W. Schmiegel
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Correspondence to W. Schmiegel.

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Pox, C., Schulmann, K. & Schmiegel, W. Konventionelles und molekulares Screening (Stuhltests). Internist 44, 287–293 (2003). https://doi.org/10.1007/s00108-002-0829-9

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