Antifungal activities of longifolene and its autoxidation products were investigated using five fungi: Trametes versicolor, Lenzites betulinus, Gloeophyllum trabeum, Trichoderma virens, and Rhizopus oryzae. Longifolene showed very little to no antifungal activity against any of the fungi. Its autoxidation products, longicamphenylol, longifolic acid, longifolene oxide, and longifolene-hydroxyketone, did show anti-fungal activities. In particular, longifolic and isolongifolic acid demonstrate strong anti-fungal activity. Longifolene autoxidation products may possess several economically viable bioactivities.
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We thank Dr. Shizuo Nagahama, Professor Emeritus of Sojo University, for supplying authentic samples. We also thank Steven M. Thompson, from Edanz Group (http://www.edanzediting.com/ac) for editing a draft of this manuscript. This research was supported by JSPS KAKENHI (Grant no. JP15K07503).
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Conflict of interest
The authors declare that they have no conflict of interest.
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