Zusammenfassung
Hintergrund
Neben dem Gesamtüberleben und rezidivfreien Intervall hat sich die posttherapeutische Lebensqualität als eigenständiges Kriterium zur Therapiebeurteilung etabliert. Dabei stellen sowohl die spezifischen Veränderungen im Kopf-Hals-Bereich als auch deren Objektivierung eine besondere Herausforderung für die Erfassung der Lebensqualität dar. Verschiedene validierte Fragebögen stehen zur Verfügung.
Ziel der Arbeit
Anhand der Literatur wird ein Überblick über die relevanten Fragebogeninstrumente gegeben, und die spezifischen Aspekte bei Patientinnen und Patienten mit Speicheldrüsenkarzinomen werden dargestellt.
Material und Methoden
In einer selektiven Literaturrecherche wurden Publikationen erfasst, die sich mit der gesundheitsbezogenen Lebensqualität bei Kopf-Hals-Tumorpatienten befassen. Die Arbeiten wurden kritisch bewertet und zusammengefasst.
Ergebnisse
Es stehen einige validierte Fragebögen zur Messung der Lebensqualität bei Patienten mit Kopf-Hals-Tumoren sowie wenige spezifische Fragebögen für Patienten nach Parotidektomie zur Verfügung.
Schlussfolgerung
Durch die Erfassung der Lebensqualität mithilfe standardisierter Fragebogeninstrumente können Krankheits- und Therapiefolgen objektiviert werden. Dadurch kann auch der Bedarf supportiver Maßnahmen, z. B. zur Rehabilitation bei Fazialisparese, verlässlicher erkannt werden.
Abstract
Background
In addition to overall survival and recurrence-free interval, posttherapeutic quality of life has been established as an independent criterion for treatment evaluation. Thereby, both the specific changes in the head and neck region and their objectification represent a particular challenge for the assessment of quality of life. There are different validated questionnaires available.
Objective
Based on the literature, an overview of the relevant questionnaire instruments is given and the specific aspects in patients with salivary gland cancer are presented.
Materials and methods
A selective literature search was conducted to collect publications dealing with the assessment of health-related quality of life in head and neck tumor patients. The papers were critically appraised and summarized.
Results
There are some validated questionnaires available to measure quality of life in patients with head and neck tumors as well as a few specific questionnaires for patients after parotidectomy.
Conclusion
By assessing quality of life using standardized questionnaire instruments, disease and treatment consequences can be objectified. Thus, the need for supportive measures, e.g., for rehabilitation in facial nerve palsy, can be identified more reliably.
Literatur
Heutte N, Plisson L, Lange M, Prevost V, Babin E (2014) Quality of life tools in head and neck oncology. Eur Ann Otorhinolaryngol Head Neck Dis 131(1):33–47. https://doi.org/10.1016/j.anorl.2013.05.002
So WK, Chan RJ, Chan DN, Hughes BG, Chair SY, Choi KC, Chan CW (2012) Quality-of-life among head and neck cancer survivors at one year after treatment—A systematic review. Eur J Cancer 48(15):2391–2408. https://doi.org/10.1016/j.ejca.2012.04.005
World Health Organization. Division of Mental Health and Prevention of Substance Abuse (1997) WHOQOL: measuring quality of life. World Health Organization. https://apps.who.int/iris/handle/10665/63482. Zugegriffen: 15. Oktober 2022
Gilbert JM, Murphy BA, Jackson L (2022) Health-related quality of life in head and neck cancer. https://www.uptodate.com/contents/health-related-quality-of-life-in-head-and-neck-cancer. Zugegriffen: 1. Mai 2022
Murphy BA, Ridner S, Wells N, Dietrich M (2007) Quality of life research in head and neck cancer: a review of the current state of the science. Crit Rev Oncol Hematol 62(3):251–267. https://doi.org/10.1016/j.critrevonc.2006.07.005
Silveira AP, Gonçalves J, Sequeira T, Ribeiro C, Lopes C, Monteiro E, Pimentel FL (2010) Patient reported outcomes in head and neck cancer: selecting instruments for quality of life integration in clinical protocols. Head Neck Oncol 31(2):32. https://doi.org/10.1186/1758-3284-2-32
Rathod S, Livergant J, Klein J, Witterick I, Ringash J (2015) A systematic review of quality of life in head and neck cancer treated with surgery with or without adjuvant treatment. Oral Oncol 51(10):888–900. https://doi.org/10.1016/j.oraloncology.2015.07.002
Cheung YB, Goh C, Thumboo J, Khoo KS, Wee J (2006) Quality of life scores differed according to mode of administration in a review of three major oncology questionnaires. J Clin Epidemiol 59(2):185–191. https://doi.org/10.1016/j.jclinepi.2005.06.011
D’Antonio LL, Zimmerman GJ, Cella DF, Long SA (1996) Quality of life and functional status measures in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 122(5):482–487. https://doi.org/10.1001/archotol.1996.01890170018005
Nie M, Liu C, Pan YC, Jiang CX, Li BR, Yu XJ, Wu XY, Zheng SN (2018) Development and evaluation of oral Cancer quality-of-life questionnaire (QOL-OC). BMC Cancer 18(1):523. https://doi.org/10.1186/s12885-018-4378-6
Singer S, Arraras JI, Chie WC, Fisher SE, Galalae R, Hammerlid E, Nicolatou-Galitis O, Schmalz C, Verdonck-de Leeuw I, Gamper E, Keszte J, Hofmeister D (2013) Performance of the EORTC questionnaire for the assessment of quality of life in head and neck cancer patients EORTC QLQ-H&N35: a methodological review. Qual Life Res 22(8):1927–1941. https://doi.org/10.1007/s11136-012-0325-1
List MA, D’Antonio LL, Cella DF, Siston A, Mumby P, Haraf D, Vokes E (1996) The performance status scale for head and neck cancer patients and the functional assessment of cancer therapy-head and neck scale. A study of utility and validity. Cancer 77(11):2294–2301
Weymuller EA Jr, Alsarraf R, Yueh B, Deleyiannis FW, Coltrera MD (2001) Analysis of the performance characteristics of the University of Washington Quality of Life instrument and its modification (UW-QOL-R). Arch Otolaryngol Head Neck Surg 127(5):489–493. https://doi.org/10.1001/archotol.127.5.489
Terrell JE, Nanavati KA, Esclamado RM, Bishop JK, Bradford CR, Wolf GT (1997) Head and neck cancer-specific quality of life: instrument validation. Arch Otolaryngol Head Neck Surg 123(10):1125–1132. https://doi.org/10.1001/archotol.1997.01900100101014
Funk GF, Karnell LH, Christensen AJ, Moran PJ, Ricks J (2003) Comprehensive head and neck oncology health status assessment. Head Neck 25(7):561–575. https://doi.org/10.1002/hed.10245
Patel N, Har-El G, Rosenfeld R (2001) Quality of life after great auricular nerve sacrifice during parotidectomy. Arch Otolaryngol Head Neck Surg 127(7):884–888
Baumann I, Cerman Z, Sertel S, Skevas T, Klingmann C, Plinkert PK (2009) Entwicklung und Validierung des Parotidectomy Outcome Inventory 8 (POI-8): Messung der Lebensqualität nach Parotidektomie bei benignen Erkrankungen. HNO 57(9):884–888. https://doi.org/10.1007/s00106-009-1991-3
Ojo B, Genden EM, Teng MS, Milbury K, Misiukiewicz KJ, Badr H (2012) A systematic review of head and neck cancer quality of life assessment instruments. Oral Oncol 48(10):923–937. https://doi.org/10.1016/j.oraloncology.2012.03.025
Laraway DC, Rogers SN (2012) A structured review of journal articles reporting outcomes using the University of Washington Quality of Life Scale. Br J Oral Maxillofac Surg 50(2):122–131. https://doi.org/10.1016/j.bjoms.2010.12.005
Fang FM, Chien CY, Kuo SC, Chiu HC, Wang CJ (2004) Changes in quality of life of head-and-neck cancer patients following postoperative radiotherapy. Acta Oncol 43(6):571–578. https://doi.org/10.1080/02841860410018430
Becker C, Pfeiffer J, Lange K, Dahlem KKK (2018) Health-related quality of life in patients with major salivary gland carcinoma. Eur Arch Otorhinolaryngol 275(4):997–1003. https://doi.org/10.1007/s00405-018-4914-7
Beutner D, Wittekindt C, Dinh S, Huttenbrink KB, Guntinas-Lichius O (2006) Impact of lateral parotidectomy for benign tumors on quality of life. Acta Otolaryngol 126(10):1091–1095. https://doi.org/10.1080/00016480600606731
Eisbruch A, Kim HM, Terrell JE, Marsh LH, Dawson LA, Ship JA (2001) Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys 50(3):695–704. https://doi.org/10.1016/s0360-3016(01)01512-7
Chen AY, Frankowski R, Bishop-Leone J, Hebert T, Leyk S, Lewin J, Goepfert H (2001) The development and validation of a dysphagia-specific quality-of-life questionnaire for patients with head and neck cancer: the M. D. Anderson dysphagia inventory. Arch Otolaryngol Head Neck Surg 127(7):870–876
Belafsky PC, Mouadeb DA, Rees CJ, Pryor JC, Postma GN, Allen J, Leonard RJ (2008) Validity and reliability of the Eating Assessment Tool (EAT-10). Ann Otol Rhinol Laryngol 117(12):919–924. https://doi.org/10.1177/000348940811701210
Nitzan D, Kronenberg J, Horowitz Z, Wolf M, Bedrin L, Chaushu G, Talmi YP (2004) Quality of life following parotidectomy for malignant and benign disease. Plast Reconstr Surg 114(5):1060–1067. https://doi.org/10.1097/01.prs.0000135326.50939.c1
Breeze J, Morrison A, Dawson D, Tipper J, Rehman K, Grew N, Pigadas N (2016) Health-related quality of life after treatment for neoplasia of the major salivary glands: a pilot study. Br J Oral Maxillofac Surg 54(7):806–811. https://doi.org/10.1016/j.bjoms.2016.05.018
Galli J, Pandolfini M, Rigante M, Schinaia L, Guidi ML, Almadori G, Paludetti G (2015) Sensory dysfunction and quality of life after great auricular nerve sacrifice during parotidectomy: our experience. J Laryngol Otol 129(11):1121–1127. https://doi.org/10.1017/S0022215115001863
Min HJ, Lee HS, Lee YS, Jeong JH, Cho SH, Lee SH, Kim KR, Park CW, Tae K (2007) Is it necessary to preserve the posterior branch of the great auricular nerve in parotidectomy? Otolaryngol Head Neck Surg 137(4):636–641. https://doi.org/10.1016/j.otohns.2007.05.061
Grosheva M, Shabli S, Volk GF, Sommer B, Ludwig L, Finkensieper M, Wittekindt C, Klussmann JP, Guntinas-Lichius O, Beutner D (2017) Sensation loss after superficial parotidectomy: A prospective controlled multicenter trial. Head Neck 39(3):520–526. https://doi.org/10.1002/hed.24647
Wolber P, Volk GF, Horstmann L, Finkensieper M, Shabli S, Wittekindt C, Klussmann JP, Guntinas-Lichius O, Beutner D, Grosheva M (2018) Patient’s perspective on long-term complications after superficial parotidectomy for benign lesions: Prospective analysis of a 2-year follow-up. Clin Otolaryngol 43(4):1073–1079. https://doi.org/10.1111/coa.13104
Fiacchini G, Cerchiai N, Tricò D, Sellari-Franceschini S, Casani AP, Dallan I, Seccia V (2018) Frey Syndrome, First Bite Syndrome, great auricular nerve morbidity, and quality of life following parotidectomy. Eur Arch Otorhinolaryngol 275(7):1893–1902. https://doi.org/10.1007/s00405-018-5014-4
Baek CH, Chung MK, Jeong HS, Son YI, Jung SC, Jeon HK, Ryu NG, Cho HJ, Cho JK, Jang JY (2009) Questionnaire evaluation of sequelae over 5 years after parotidectomy for benign diseases. J Plast Reconstr Aesthet Surg 62(5):633–638. https://doi.org/10.1016/j.bjps.2007.08.034
Grosheva M, Klussmann JP, Grimminger C, Wittekindt C, Beutner D, Pantel M, Volk GF, Guntinas-Lichius O (2009) Electromyographic facial nerve monitoring during parotidectomy for benign lesions does not improve the outcome of postoperative facial nerve function: a prospective two-center trial. Laryngoscope 119(12):2299–2305. https://doi.org/10.1002/lary.20637
Chiesa-Estomba CM, Larruscain-Sarasola E, Lechien JR, Mouawad F, Calvo-Henriquez C, Diom ES, Ramirez A, Ayad T (2021) Facial nerve monitoring during parotid gland surgery: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol 278(4):933–943. https://doi.org/10.1007/s00405-020-06188-0
Grosheva M, Pick C, Granitzka T, Sommer B, Wittekindt C, Klussmann JP, Guntinas-Lichius O, Beutner D (2019) Impact of extent of parotidectomy on early and long-term complications: A prospective multicenter cohort trial. Head Neck 41(6):1943–1951. https://doi.org/10.1002/hed.25651
Guntinas-Lichius O, Silver CE, Thielker J, Bernal-Sprekelsen M, Bradford CR, De Bree R, Kowalski LP, Olsen KD, Quer M, Rinaldo A, Rodrigo JR, Sanabria A, Shaha AR, Takes RP, Vander Poorten V, Zbären P, Ferlito A (2018) Management of the facial nerve in parotid cancer: preservation or resection and reconstruction. Eur Arch Otorhinolaryngol 275(11):2615–2626. https://doi.org/10.1007/s00405-018-5154-6
Robinson MW, Baiungo J (2018) Facial rehabilitation: evaluation and treatment strategies for the patient with facial palsy. Otolaryngol Clin North Am 51(6):1151–1167. https://doi.org/10.1016/j.otc.2018.07.011
Wax MK, Talmi YP (2016) Quality of life after salivary gland surgery. Adv Otorhinolaryngol 78:189–197. https://doi.org/10.1159/000442140
Guntinas-Lichius O, Straesser A, Streppel M (2007) Quality of life after facial nerve repair. Laryngoscope 117(3):421–426. https://doi.org/10.1097/MLG.0b013e31802d83df
Luijmes RE, Pouwels S, Beurskens CH, Kleiss IJ, Siemann I, Ingels KJ (2017) Quality of life before and after different treatment modalities in peripheral facial palsy: A systematic review. Laryngoscope 127(5):1044–1051. https://doi.org/10.1002/lary.26356
Watts TL, Chard R, Weber SM, Wax MK (2011) Immediate eye rehabilitation at the time of facial nerve sacrifice. Otolaryngol Head Neck Surg 144(3):353–356. https://doi.org/10.1177/0194599810394314
Djan R, Penington A (2013) A systematic review of questionnaires to measure the impact of appearance on quality of life for head and neck cancer patients. J Plast Reconstr Aesthet Surg 66(5):647–659. https://doi.org/10.1016/j.bjps.2013.01.007
Al-Mamgani A, van Rooij P, Verduijn GM, Meeuwis CA, Levendag PC (2012) Long-term outcomes and quality of life of 186 patients with primary parotid carcinoma treated with surgery and radiotherapy at the Daniel den Hoed Cancer Center. Int J Radiat Oncol Biol Phys 84(1):189–195. https://doi.org/10.1016/j.ijrobp.2011.11.045
National Cancer Insitute (2021) Common Terminology Criteria for Adverse Events (CTCAE). https://ctep.cancer.gov/protocoldevelopment/electronic_applications/ctc.htm#ctc_50. Zugegriffen: 15. Oktober 2022
Stenner M, Beenen F, Hahn M, Koopmann M, Weiss D, Hüttenbrink KB (2016) Exploratory study of long-term health-related quality of life in patients with surgically treated primary parotid gland cancer. Head Neck 38(1):111–117. https://doi.org/10.1002/hed.23858
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V. Burkhardt und C. Becker geben an, dass kein Interessenkonflikt besteht.
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Burkhardt, V., Becker, C. Posttherapeutische Lebensqualität nach Behandlung von Speicheldrüsenkarzinomen. HNO 71, 250–255 (2023). https://doi.org/10.1007/s00106-023-01286-x
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DOI: https://doi.org/10.1007/s00106-023-01286-x
Schlüsselwörter
- Fragebogen
- Kopf-Hals-Tumoren
- Gesamtüberleben
- Mechanismen zur Beurteilung der Gesundheitsversorgung
- Rehabilitation