Abstract
Human papillomavirus (HPV)-associated squamous cell carcinoma of the oropharynx is a malignancy of increasing prevalence. The oncologic community is currently evaluating the safety and efficacy of de-intensifying treatment without compromising oncologic outcomes. Paramount to these treatment algorithms is primary surgery through transoral approaches. This article reviews the literature and concepts pertaining to transoral surgery and describes the two most common techniques, transoral laser microsurgery (TLM) and transoral robotic surgery (TORS).
Zusammenfassung
Das mit dem humanen Papillomavirus (HPV) assoziierte Plattenepithelkarzinom des Oropharynx ist ein Malignom mit zunehmender Prävalenz. In der onkologischen Fachwelt werden derzeit die Sicherheit und Wirksamkeit deintensivierender Behandlungsansätze ohne Beeinträchtigung der onkologischen Ergebnisse geprüft. Von entscheidender Bedeutung bei diesen Behandlungsalgorithmen ist die primäre Chirurgie über transorale Zugangswege. In der vorliegenden Arbeit wird ein Überblick über die Literatur und Konzepte in Bezug auf die transorale Chirurgie gegeben, und es werden die beiden am meisten verbreiteten Verfahren beschrieben, die transorale Lasermikrochirurgie (TLM) und die transorale robotische Chirurgie (TORS).
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References
Parsons JT, Mendenhall WM, Stringer SP et al (2002) Squamous cell carcinoma of the oropharynx: surgery, radiation therapy, or both. Cancer 94(11):2967–2980
O’Sullivan B, Huang SH, Su J et al (2016) Development and validation of a staging system for HPV-related oropharyngeal cancer by the international collaboration on oropharyngeal cancer network for staging (ICON-S): a multicentre cohort study. Lancet Oncol 17(4):440–451
Huang SH, Xu W, Waldron J et al (2015) Refining American joint committee on cancer/union for international cancer control TNM stage and prognostic groups for human papillomavirus-related oropharyngeal carcinomas. J Clin Oncol 33:836–845
Zhan KY, Eskander A, Kang SY et al (2017) Appraisal of the AJCC 8th edition pathologic staging modifications for HPV-positive oropharyngeal cancer, a study of the national cancer data base. Oral Oncol 73:152–159
Haughey BH, Sinha P, Kallogjeri D et al (2016) Pathology-based staging for HPV-positive squamous cell carcinoma of the oropharynx. Oral Oncol 62:11–19
Kelly JR, Husain ZA, Burtness B (2016) Treatment de-intensification strategies for head and neck cancer. Eur J Cancer 68:125–133
Moore EJ, Olsen KD, Kasperbauer JL (2009) Transoral robotic surgery for oropharyngeal squamous cell carcinoma: a prospective study of feasibility and functional outcomes. Laryngoscope 119(11):2156–2164
Rich JT, Liu J, Haughey BH (2011) Swallowing function after transoral laser microsurgery (TLM) adjuvant therapy for advanced-stage oropharyngeal cancer. Laryngoscope 121(11):2381–2390
Canis M, Ihler F, Wolff HA et al (2013) Oncologic and functional results after transoral laser microsurgery of tongue base carcinoma. Eur Arch Otorhinolaryngol 270(3):1075–1083
Steiner W (1988) Experience in endoscopic laser surgery of malignant tumors of the upper aerodigestive tract. Adv Otorhinolaryngol 39:135–144
Steiner W, Fierek O, Ambrosch P et al (2003) Transoral laser microsurgery for squamous cell carcinoma of the base of the tongue. Arch Otolaryngol Head Neck Surg 129(1):36–43
Grant DG, Salassa JR, Hinni ML et al (2006) Carcinoma of the tongue base treated by transoral laser microsurgery, part one: untreated tumors, a prospective analysis of oncologic and functional outcomes. Laryngoscope 116(12):2150–2155
Grant DG, Hinni ML, Salassa JR et al (2009) Oropharyngeal cancer: a case for single modality treatment with transoral laser microsurgery. Arch Otolaryngol Head Neck Surg 135(12):1225–1230
Rich JT, Milov S, Lewis JS Jr et al (2009) Transoral laser microsurgery (TLM) +/− adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors. Laryngoscope 119(9):1709–1719
Haughey BH, Hinni ML, Salassa JR et al (2011) Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer: a United States multicenter study. Head Neck 33(12):1683–1694
Canis M, Martin A, Kron M et al (2013) Results of transoral laser microsurgery in 102 patients with squamous cell carcinoma of the tonsil. Eur Arch Otorhinolaryngol 270(8):2299–2306
Sinha P, Haughey BH, Kallogjeri D et al (2019) Long-term analysis of transorally resected p16 + oropharynx cancer: outcomes and prognostic factors. Laryngoscope 129(5):1141–1149
Weiss BG, Ihler F, Anczykowski MZ et al (2019) Transoral laser microsurgery for treatment of oropharyngeal cancer in 368 patients. Head Neck 41(9):3144–3158
Hockstein NG, Nolan JP, Malley OBW et al (2005) Robot-assisted pharyngeal and laryngeal microsurgery: results of robotic cadaver dissections. Laryngoscope 115(6):1003–1008
O’Malley BW Jr, Weinstein GS, Snyder W et al (2006) Transoral robotic surgery (TORS) for base of tongue neoplasms. Laryngoscope 116(8):1465–1472
Weinstein GS, O’Malley BW Jr, Cohen MA et al (2010) Transoral robotic surgery for advanced oropharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 136(11):1079–1085
Cohen MA, Weinstein GS, O’Malley BW Jr et al (2011) Transoral robotic surgery and human papillomavirus status: oncologic results. Head Neck 33(4):573–580
Weinstein GS, O’Malley BW Jr, Magnuson JS et al (2012) Transoral robotic surgery: a multicenter study to assess feasibility, safety, and surgical margins. Laryngoscope 122(8):1701–1707
de Almeida JR, Byrd JK, Wu R et al (2014) A systematic review of transoral robotic surgery and radiotherapy for early oropharynx cancer: a systematic review. Laryngoscope 124(9):2096–2102
De Virgilio A, Costantino A, Mercante G et al (2021) Transoral robotic surgery and intensity-modulated radiotherapy in the treatment of the oropharyngeal carcinoma: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol 278(5):1321–1335
de Almeida JR, Li R, Magnuson JS et al (2015) Oncologic outcomes after transoral robotic surgery: a multi-institutional study. JAMA Otolaryngol Head Neck Surg 141(12):1043–1051
Liboon J, Funkhouser W, Terris DJ (1997) A comparison of mucosal incisions made by scalpel, CO2 laser, electrocautery, and constant-voltage electrocautery. Otolaryngol Head Neck Surg 116(3):379–385
Carew JF, Ward RF, LaBruna A et al (1998) Effects of scalpel, electrocautery, and CO2 and KTP lasers on wound healing in rat tongues. Laryngoscope 108(3):373–380
Sinha UK, Gallagher LA (2003) Effects of steel scalpel, ultrasonic scalpel, CO2 laser, and monopolar and bipolar electrosurgery on wound healing in guinea pig oral mucosa. Laryngoscope 113(2):228–236
Makki FM, Rigby MH, Bullock M et al (2014) CO(2) laser versus cold steel margin analysis following endoscopic excision of glottic cancer. J Otolaryngol Head Neck Surg 43(1):6
Hoffmann TK, Schuler PJ, Bankfalvi A et al (2014) Comparative analysis of resection tools suited for transoral robot-assisted surgery. Eur Arch Otorhinolaryngol 271(5):1207–1213
Desai S, Sung C, Jang D et al (2008) Transoral robotic surgery using a carbon dioxide flexible laser for tumors of the upper aerodigestive tract. Laryngoscope 118(12):2187–2189
Hinni ML, Zarka MA, Hoxworth JM (2013) Margin mapping in transoral surgery for head and neck cancer. Laryngoscope 123(5):1190–1198
Tomblinson CM, Fletcher GP, Hu LS et al (2021) Determination of posterolateral oropharyngeal wall thickness and the potential implications for transoral surgical margins in tonsil cancer. Head Neck 43(7):2185–2192
Moore EJ, Van Abel KM, Price DL et al (2018) Transoral robotic surgery for oropharyngeal carcinoma: surgical margins and oncologic outcomes. Head Neck 40(4):747–755
Holcomb AJ, Herberg M, Strohl M et al (2021) Impact of surgical margins on local control in patients undergoing single-modality transoral robotic surgery for HPV-related oropharyngeal squamous cell carcinoma. Head Neck 43(8):2434–2444
Hinni ML, Ferlito A, Brandwein-Gensler MS et al (2013) Surgical margins in head and neck cancer: a contemporary review. Head Neck 35(9):1362–1370
Holsinger C, McWhorter A, Ménard M et al (2005) Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region: I. Technique, complications, and functional results. Arch Otolaryngol Head Neck Surg 131(7):583–591
Dombrée M, Crott R, Lawson G et al (2014) Cost comparison of open approach, transoral laser microsurgery and transoral robotic surgery for partial and total laryngectomies. Eur Arch Otorhinolaryngol 271(10):2825–2834
Parimbelli E, Soldati F, Duchoud L et al (2021) Cost-utility of two minimally-invasive surgical techniques for operable oropharyngeal cancer: transoral robotic surgery versus transoral laser microsurgery. BMC Health Serv Res 21(1):1173
Sievert M, Goncalves M, Zbidat A et al (2021) Outcomes of transoral laser microsurgery and transoral robotic surgery in oropharyngeal squamous cell carcinoma. Auris Nasus Larynx 48(2):295–301
Sumer BD, Goyal V, Truelson JM et al (2013) Transoral robotic surgery and transoral laser microsurgery for oropharyngeal squamous cell cancer. J Robot Surg 7(4):377–383
Li H, Torabi SJ, Park HS et al (2019) Clinical value of transoral robotic surgery: nationwide results from the first 5 years of adoption. Laryngoscope 129(8):1844–1855
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T.H. Nagel, B.A. Chang and M.L. Hinni declare that they have no competing interests.
For this article no studies with human participants or animals were performed by any of the authors. All studies mentioned were in accordance with the ethical standards indicated in each case.
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Nagel, T.H., Chang, B.A. & Hinni, M.L. Robotic vs. transoral laser surgery of malignant oropharyngeal tumors—what is best for the patient?. HNO 70, 371–379 (2022). https://doi.org/10.1007/s00106-022-01165-x
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DOI: https://doi.org/10.1007/s00106-022-01165-x
Keywords
- Head and neck cancer
- Human papillomavirus
- Surgery, oral
- Transoral laser microsurgery
- Robot-assisted surgery