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Volumenänderungen der grauen Hirnsubstanz bei Anosmikern

Erkenntnisse durch voxelbasierte Morphometrie

Volume alterations in the gray matter of anosmic subjects

Lessons we can learn from voxel-based morphometry

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Zusammenfassung

Veränderungen des zentralen Nervensystems nach einem Verlust des Riechvermögens wurden bisher vor allem für den Bulbus olfactorius (OB) beschrieben. Wir stellen eine Studie zu voxelbasierter Morphometrie (VBM) vor, die Hirnveränderungen bei Patienten mit Anosmie in dem OB übergeordneten Arealen darstellt. Datensätze von 17 Patienten mit Anosmie sowie von 17 normosmischen Kontrollpersonen wurden auf einem 3-T-Magnetresonanztomographen aufgezeichnet. Die Datenverarbeitung und Auswertung erfolgte mit der SPM5-Software (Wellcome Department of Imaging Neuroscience Group, London, UK) und der hierin implementierten VBM5-Toolbox. Die Patientengruppe zeigte eine signifikante Volumenabnahme der grauen Hirnsubstanz sowohl im primären olfaktorischen Kortex als auch in sekundären olfaktorischen Arealen (Insula, orbitofrontaler Kortex, Cingulum, Hippokampus). Auch wurden größere Volumenabnahmen im Nucleus accumbens mit dem angrenzenden Gyrus subcallosus sowie im dorsolateralen präfrontalen Kortex gefunden. Eine längere Erkrankungsdauer war mit ausgeprägteren Gehirnveränderungen verbunden. VBM ist somit geeignet, Hirnveränderungen bei Patienten mit Riechstörungen darzustellen.

Abstract

Alterations in the central nervous system in patients with a loss of sense of smell are well documented for the olfactory bulb (OB). Here we present a voxel-based morphometry (VBM) study on cerebral alterations in the gray matter of patients with anosmia above the OB. 3-Tesla MRI datasets were obtained from 17 patients with anosmia as well as from 17 normosmic controls. Data processing and evaluation was performed using the SPM5 software package (Wellcome Department of Imaging Neuroscience Group, London, UK) and the implemented VBM5 toolbox. Patients with anosmia showed a significant volume decrease in the gray matter in the primary olfactory cortex as well as in secondary olfactory areas (insular cortex, orbitofrontal cortex, cingulate cortex and hippocampus). Furthermore, volume decreases in areas like the nucleus accumbens with adjacent subcallosal gyrus and the dorsolateral prefrontal cortex were found. Longer disease duration was associated with more profound alterations in the gray matter. VBM is appropriate to document brain alterations in patients with olfactory disorders.

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Authors and Affiliations

  1. Klinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Jena, Lessingstraße 2, 07740, Jena, Deutschland

    T. Bitter, H. Gudziol & O. Guntinas-Lichius

  2. Institut für Diagnostische und Interventionelle Radiologie I, Universitätsklinikum Jena, Jena, Deutschland

    H.P. Burmeister & H.-J. Mentzel

  3. Arbeitsgruppe Neuroimaging, Klinik für Psychiatrie, Universitätsklinikum Jena, Jena, Deutschland

    C. Gaser

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  1. T. Bitter
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  2. H. Gudziol
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  4. H.-J. Mentzel
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  5. C. Gaser
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  6. O. Guntinas-Lichius
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Correspondence to T. Bitter.

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Daten aus der hier vorgestellten Studie wurden bereits andernorts publiziert [5].

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Bitter, T., Gudziol, H., Burmeister, H. et al. Volumenänderungen der grauen Hirnsubstanz bei Anosmikern. HNO 59, 248–254 (2011). https://doi.org/10.1007/s00106-011-2267-2

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