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Was leisten die neuen Bestrahlungstechniken?

What is the impact of new radiotherapy techniques?

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Zusammenfassung

Die Radioonkologie spielt neben operativen und chemotherapeutischen Vorgehen eine entscheidende Rolle in der Therapie von Kopf-Hals-Tumoren. Dabei fand in den letzten Jahren eine rasante Entwicklung neuer technischer Möglichkeiten statt. Zum einen werden moderne Bildgebungsverfahren sowohl in die Bestrahlungsplanung als auch in die Bestrahlungsgeräte selbst integriert. Zum anderen erlauben technische Neuerungen die maßgeschneiderte Anpassung der Bestrahlungsfelder und Dosisverteilungen an komplexe Tumorgeometrien. Hierbei können gleichzeitig Risikoorgane besser geschont und somit verminderte Toxizitäten erzielt werden. Diese Übersichtsarbeit stellt die neuen Techniken der Radioonkologie vor und erläutert die Auswirkungen auf neue Therapieoptionen und die Lebensqualität der Patienten.

Abstract

Radiation oncology, along with surgery and chemotherapy, is one of the cornerstones in the treatment of head and neck tumors. Within the last years, this field has experienced a remarkable evolution of new technical possibilities. New imaging modalities have been introduced into radiation planning and into linear accelerators themselves. In addition, new techniques enable the tailor-made conformation of radiation beams and dose distributions to complex tumor geometries. At the same time, organs at risk can be spared, and long-term toxicities are considerably reduced. This report presents the new techniques in radiation oncology and describes the effects on new treatment options and patients’ quality of life.

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Literatur

  1. Baier G, Volter C, Steigerwald I et al. (2005) Malignant paranasal sinus tumors. Diagnosis, therapy and results. HNO 53: 957–965

    Article  PubMed  CAS  Google Scholar 

  2. Ben-David MA, Diamante M, Radawski JD et al. (2007) Lack of osteoradionecrosis of the mandible after intensity-modulated radiotherapy for head and neck cancer: likely contributions of both dental care and improved dose distributions. Int J Radiat Oncol Biol Phys 68: 396–402

    PubMed  Google Scholar 

  3. Bonner JA, Harari PM, Giralt J et al. (2006) Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354: 567–578

    Article  PubMed  CAS  Google Scholar 

  4. Brada M, Pijls-Johannesma M, De Ruysscher D (2007) Proton therapy in clinical practice: current clinical evidence. J Clin Oncol 25: 965–970

    Article  PubMed  Google Scholar 

  5. Feng FY, Kim HM, Lyden TH et al. (2007) Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys 68: 1289–1298

    PubMed  Google Scholar 

  6. Graff P, Lapeyre M, Desandes E et al. (2007) Impact of intensity-modulated radiotherapy on health-related quality of life for head and neck cancer patients: matched-pair comparison with conventional radiotherapy. Int J Radiat Oncol Biol Phys 67: 1309–1317

    PubMed  Google Scholar 

  7. Harari PM, Allen GW, Bonner JA (2007) Biology of interactions: antiepidermal growth factor receptor agents. J Clin Oncol 25: 4057–4065

    Article  PubMed  CAS  Google Scholar 

  8. Hodge CW, Bentzen SM, Wong G et al. (2007) Are we influencing outcome in oropharynx cancer with intensity-modulated radiotherapy? An inter-era comparison. Int J Radiat Oncol Biol Phys 69: 1032–1041

    PubMed  Google Scholar 

  9. Hoppe BS, Stegman LD, Zelefsky MJ et al. (2007) Treatment of nasal cavity and paranasal sinus cancer with modern radiotherapy techniques in the postoperative setting–the MSKCC experience. Int J Radiat Oncol Biol Phys 67: 691–702

    PubMed  Google Scholar 

  10. Klem ML, Mechalakos JG, Wolden SL et al. (2007) Intensity-modulated radiotherapy for head and neck cancer of unknown primary: toxicity and preliminary efficacy. Int J Radiat Oncol Biol Phys 70: 1100–1107

    PubMed  Google Scholar 

  11. Lee N, Chan K, Bekelman JE et al. (2007) Salvage re-irradiation for recurrent head and neck cancer. Int J Radiat Oncol Biol Phys 68: 731–740

    PubMed  Google Scholar 

  12. Lee N, Xia P, Fischbein NJ et al. (2003) Intensity-modulated radiation therapy for head-and-neck cancer: the UCSF experience focusing on target volume delineation. Int J Radiat Oncol Biol Phys 57: 49–60

    Article  PubMed  Google Scholar 

  13. Mizoe JE, Tsujii H, Kamada T et al. (2004) Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 60: 358–364

    PubMed  Google Scholar 

  14. Münter MW, Karger CP, Hoffner SG et al. (2004) Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphy. Int J Radiat Oncol Biol Phys 58: 175–184

    Article  PubMed  Google Scholar 

  15. Münter MW, Schulz-Ertner D, Hof H et al. (2006) Inverse planned stereotactic intensity modulated radiotherapy (IMRT) in the treatment of incompletely and completely resected adenoid cystic carcinomas of the head and neck: initial clinical results and toxicity of treatment. Radiat Oncol 1: 17

    Article  PubMed  Google Scholar 

  16. Münter MW, Thilmann C, Hof H et al. (2003) Stereotactic intensity modulated radiation therapy and inverse treatment planning for tumors of the head and neck region: clinical implementation of the step and shoot approach and first clinical results. Radiother Oncol 66: 313–321

    Article  PubMed  Google Scholar 

  17. Nishimura H, Ogino T, Kawashima M et al. (2007) Proton-beam therapy for olfactory neuroblastoma. Int J Radiat Oncol Biol Phys 68: 758–762

    PubMed  Google Scholar 

  18. Olsen DR, Bruland OS, Frykholm G et al. (2007) Proton therapy – a systematic review of clinical effectiveness. Radiother Oncol 83: 123–132

    Article  PubMed  Google Scholar 

  19. Pfister DG, Laurie SA, Weinstein GS et al. (2006) American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol 24: 3693–3704

    Article  PubMed  Google Scholar 

  20. Pommier P, Liebsch NJ, Deschler DG et al. (2006) Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg 132: 1242–1249

    Article  PubMed  Google Scholar 

  21. Pow EH, Kwong DL, McMillan AS et al. (2006) Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial. Int J Radiat Oncol Biol Phys 66: 981–991

    PubMed  Google Scholar 

  22. Schulz-Ertner D, Jakel O, Schlegel W (2006) Radiation therapy with charged particles. Semin Radiat Oncol 16: 249–259

    Article  PubMed  Google Scholar 

  23. Schulz-Ertner D, Karger CP, Feuerhake A et al. (2007) Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas. Int J Radiat Oncol Biol Phys 68: 449–457

    PubMed  Google Scholar 

  24. Schulz-Ertner D, Nikoghosyan A, Didinger B et al. (2005) Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques. Cancer 104: 338–344

    Article  PubMed  Google Scholar 

  25. Schulz-Ertner D, Nikoghosyan A, Hof H et al. (2007) Carbon ion radiotherapy of skull base chondrosarcomas. Int J Radiat Oncol Biol Phys 67: 171–177

    PubMed  Google Scholar 

  26. Schulz-Ertner D, Tsujii H (2007) Particle radiation therapy using proton and heavier ion beams. J Clin Oncol 25: 953–964

    Article  PubMed  Google Scholar 

  27. Slater JD, Yonemoto LT, Mantik DW et al. (2005) Proton radiation for treatment of cancer of the oropharynx: early experience at Loma Linda University Medical Center using a concomitant boost technique. Int J Radiat Oncol Biol Phys 62: 494–500

    PubMed  Google Scholar 

  28. Sterzing F, Schubert K, Sroka-Perez G et al. (2008) Helical tomotherapy: experiences of the first 150 patients in Heidelberg. Strahlenther Onkol 184: 8–14

    Article  PubMed  Google Scholar 

  29. Taheri-Kadkhoda Z, Bjork-Eriksson T, Nill S et al. (2008) Intensity-modulated radiotherapy of nasopharyngeal carcinoma: A comparative treatment planning study of photons and protons. Radiat Oncol 3: 4

    Article  PubMed  Google Scholar 

  30. Tokuuye K, Akine Y, Kagei K et al. (2004) Proton therapy for head and neck malignancies at Tsukuba. Strahlenther Onkol 180: 96–101

    Article  PubMed  Google Scholar 

  31. Wolden SL, Chen WC, Pfister DG et al. (2006) Intensity-modulated radiation therapy (IMRT) for nasopharynx cancer: update of the Memorial Sloan-Kettering experience. Int J Radiat Oncol Biol Phys 64: 57–62

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Abteilung für Radioonkologie und Strahlentherapie, Universitätsklinikum, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland

    F. Sterzing, A.D. Jensen, K.K. Herfarth & J. Debus

  2. Klinische Kooperationseinheit Strahlentherapeutische Onkologie, Deutsches Krebsforschungszentrum (dkfz), Heidelberg, Deutschland

    M.W. Münter, E.M. Stoiber & P. Huber

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  1. F. Sterzing
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  2. M.W. Münter
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  3. A.D. Jensen
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  4. E.M. Stoiber
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  5. P. Huber
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  6. K.K. Herfarth
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  7. J. Debus
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Correspondence to F. Sterzing.

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Sterzing, F., Münter, M., Jensen, A. et al. Was leisten die neuen Bestrahlungstechniken?. HNO 56, 585–593 (2008). https://doi.org/10.1007/s00106-008-1719-9

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  • DOI: https://doi.org/10.1007/s00106-008-1719-9

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